FlyBase Allele Report: Dmel\dally[80]

General Information

Symbol

Dmel\dally⁸⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0155414

Feature type

allele

Associated gene

Dmel\dally

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Kirkpatrick et al., 2006)

Mutagen

P-element activity

(Han et al., 2004)

Progenitor genotype

dally^P1

(Han et al., 2004)

Cytology

Description

Imprecise excision of P{lacZ}dally^P1 has lead to a deletion of -724 to +415 od dally (Where the A in the ATG start codon is designated as 1).

(Han et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Baron et al., 2009)

decreased cell number

(Eugster et al., 2007)

increased cell death | larval stage | somatic clone

(Merino et al., 2022)

lethal - all die before end of larval stage

(Baron et al., 2009)

some die during third instar larval stage

(Baron et al., 2009)

visible

(Eugster et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

dally⁸⁰ heterozygotes resist infection with wild-type group B streptococcus.

dally⁸⁰ heterozygotes survive longer than wild-type flies when infected with ACP-GAG binding impaired group B streptococcus.

(Baron et al., 2009)

The ovarioles of homozygous females show loss of the germline stem cells (GSCs), with 45% of ovarioles containing no GSCs in the niche at day 3 after eclosion.

The ovarioles of dally⁰⁶⁴⁶⁴/dally⁸⁰ females show progressive loss of the germline stem cells (GSCs), with 59% of ovarioles containing no GSCs in the niche at day 10 after eclosion.

(Guo and Wang, 2009)

Wings of homozygous adults are smaller than normal, primarily due to a reduction in cell number rather than cell size.

(Eugster et al., 2007)

dally⁸⁰/Df(3L)Scf-R6 flies show a reduction in the number of chemosensory bristles at the anterior margin of the wing compared to wild-type flies. The L5 vein in the wings of these flies does not form properly and stops short between the posterior crossvein and the wing margin. These mutants also show a loss of the anterior dorsocentral bristles and the posterior supraalar bristles on the notum.

(Kirkpatrick et al., 2006)

When dally⁸⁰ mutant clones are made in the wing disc a loss of sensory organ precursors are seen. Mutant adults escapers exhibit reduced number of chemosensory bristles on the wing.

(Han et al., 2005)

Somatic clones of dally⁸⁰ homozygous cells in the wing lead to a partial loss of the L5 vein with a high penetrance, but no detectable defects in the central domain of wing blade.

(Han et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dally⁸⁰ has abnormal immune response phenotype, enhanceable by dlp^A187

(Baron et al., 2009)

dally⁸⁰, dlp^A187 has abnormal immune response phenotype, enhanceable by Df(2R)48

(Baron et al., 2009)

dally⁸⁰ has abnormal immune response phenotype, enhanceable by dlp^A187/Df(2R)48

(Baron et al., 2009)

Enhancer of

Statement

Reference

dally⁸⁰/dally[+] is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

dally⁸⁰ has mechanosensory chaeta phenotype, non-enhanceable by Sulf1^Δ1

(You et al., 2011)

dally⁸⁰ has taste bristle phenotype, non-enhanceable by Sulf1^Δ1

(You et al., 2011)

Lar^bypass, dally⁸⁰ has anterior fascicle & axon | ectopic phenotype, non-enhanceable by dlp^A187

(Fox and Zinn, 2005)

NOT suppressed by

Statement

Reference

dally⁸⁰ has mechanosensory chaeta phenotype, non-suppressible by Sulf1^Δ1

(You et al., 2011)

dally⁸⁰ has taste bristle phenotype, non-suppressible by Sulf1^Δ1

(You et al., 2011)

dally⁸⁰ has sensory mother cell | somatic clone phenotype, non-suppressible by Notum^I6

(Han et al., 2005)

Enhancer of

Statement

Reference

dally⁸⁰/dally[+] is an enhancer of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

NOT Enhancer of

Statement

Reference

dally⁸⁰ is a non-enhancer of anterior fascicle & axon | ectopic phenotype of Lar^bypass, dlp^A187

(Fox and Zinn, 2005)

Suppressor of

Statement

Reference

dally⁸⁰/dally[+] is a suppressor | partially of wing phenotype of Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

dally⁸⁰/dally[+] is a suppressor | partially of wing margin bristle phenotype of Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

dally⁸⁰ is a suppressor of taste bristle | increased number phenotype of Sulf1^Δ1

(You et al., 2011)

dally⁸⁰ is a suppressor of mechanosensory chaeta | increased number phenotype of Sulf1^Δ1

(You et al., 2011)

Other

Statement

Reference

dally⁸⁰, dlp^A187 has posterior crossvein | somatic clone | cell non-autonomous phenotype

(Chen et al., 2012)

dally⁸⁰, dlp^A187 has wing vein L4 | somatic clone phenotype

(Han et al., 2004)

dally⁸⁰, dlp^A187 has wing vein L3 | somatic clone phenotype

(Han et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Wing disc clones mutant for dally⁸⁰ and dlp^A187 often have incomplete or fragmented posterior crossveins. This effect is not cell-autonomous.

(Chen et al., 2012)

The commissural axon phenotype (failure to cross the midline) seen in embryos expressing Sema-1a^Scer\UAS.cYa under the control of Scer\GAL4^P52 in a Sema-1a^k13702 null background is significantly enhanced if the embryos are also heterozygous for dally⁸⁰.

(Cho et al., 2012)

dally⁸⁰ dlp^A187 Df(2R)48 triple heterozygotes exhibit increased median survival time compared to controls when infected with group B Streptococcus (both wild-type and GAG-binding impaired mutants) and lower colony counts after infection.

(Wang et al., 2011)

dally⁸⁰ Sulf1^Δ1 double mutants exhibit a phenotype similar to dally⁸⁰ single mutants (a reduced number of bristles on the wing margin).

(You et al., 2011)

The ability of dlp^-HS.Scer\UAS expressed under the control of Scer\GAL4^prd.RG1 to rescue naked cuticle patterning in dlp^A187 embryos derived from dlp^A187 female germline clones is not affected if the embryos are also mutant for dally⁸⁰.

(Yan et al., 2010)

dally⁸⁰ dlp^A187 double heterozygotes resist infection with wild-type group B streptococcus (to a greater extent than single mutants).

dally⁸⁰ dlp^A187 Df(2R)48 triple heterozygotes resist infection with wild-type group B streptococcus (to a greater extent than single and double mutants).

dally⁸⁰ dlp^A187 Df(2R)48 triple heterozygous mutants survive longer than wild-type flies when infected with ACP-GAG binding impaired group B streptococcus.

(Baron et al., 2009)

dlp^A187, dally⁸⁰ mutants display ISNb bypass at a similar rate to wild-type embryos. The Lar^bypass ISNb phenotype is not enhanced in Lar^bypass; dlp^A187, dally⁸⁰ triple mutants.

(Fox and Zinn, 2005)

When dally⁸⁰/Notum^I6 double mutant clones are made in the wing disc, reduced numbers of sensory organ precursors are seen in large clones.

(Han et al., 2005)

Somatic clones of dally⁸⁰; dlp^A187 doubly homozygous cells in the wing lead to L3-L4 fusion, a phenotype not seen with single mutants clones.

(Han et al., 2004)

Xenogenetic Interactions

Statement

Reference

One copy of dally⁸⁰ partially suppresses the wing margin defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62.

(Avanesov et al., 2012)

Complementation and Rescue Data

Rescued by

dally⁸⁰ is rescued by dally^UAS.GFP/Scer\GAL4^en-GAL4-33

(Eugster et al., 2007)

Partially rescued by

dally⁸⁰ is partially rescued by dally^{Δgpi.UAS.GFP}/Scer\GAL4^en-GAL4-33

(Eugster et al., 2007)

dally⁸⁰/Df(3L)Scf-R6 is partially rescued by Scer\GAL4^A9/dally^ΔGAG.UAS

(Kirkpatrick et al., 2006)

Comments

Expression of dally^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-GAL4-33 increases the size of both the posterior and anterior compartments of the wing in dally⁸⁰ adults.

Expression of dally^{Δgpi.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-GAL4-33 increases the size of the anterior compartment but not the posterior compartment of the wing in dally⁸⁰ adults.

(Eugster et al., 2007)

Expression of dally^{ΔGAG.Scer\UAS} under the control of Scer\GAL4^A9 partially rescues the phenotypes of dally⁸⁰/Df(3L)Scf-R6 mutants. The transgene substantially restores chemosensory bristle numbers in the wing margin, almost fully rescues the formation of wing vein L5, almost fully restores the formation of the anterior dorsocentral bristles on the notum without inducing the formation of extra ones for all mutants. However, it fails to restore formation of the posterior supraalar bristles.

(Kirkpatrick et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dally⁸⁰

(Liu et al., 2024, Merino et al., 2022, Avanesov and Blair, 2013, Sekine et al., 2013, Zhang et al., 2013, Avanesov et al., 2012, Chen et al., 2012, Cho et al., 2012, Wang et al., 2011, You et al., 2011, Yan et al., 2010, Baron et al., 2009, Guo and Wang, 2009, Crickmore and Mann, 2007, Eugster et al., 2007, Yan and Lin, 2007, Kirkpatrick et al., 2006, Glise et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (22)

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