FlyBase Allele Report: Dmel\armi[72.1]

General Information

Symbol

Dmel\armi^72.1

Species

D. melanogaster

Name

FlyBase ID

FBal0155636

Feature type

allele

Associated gene

Dmel\armi

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Cook et al., 2004)

Mutagen

Delta2-3 transposase

(Cook et al., 2004)

Progenitor genotype

armi¹

(Cook et al., 2004, Tomari et al., 2004)

Cytology

Description

Imprecise excision of the P-element, resulting in a deletion of armi sequences in the 5' untranslated region.

(Tomari et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory (with Df(3L)E1)

(Ashraf et al., 2006)

abnormal memory | recessive

(Ashraf et al., 2006)

female sterile

(Cook et al., 2004)

lethal - all die during embryonic stage | maternal effect (with armi¹)

(Orsi et al., 2010)

male semi-fertile (with armi¹)

(Venkei et al., 2023)

male semi-sterile

(Tomari et al., 2004)

some die during embryonic stage | maternal effect (with armi¹)

(Orsi et al., 2010)

Phenotype Manifest In

dorsal appendage (with armi¹)

(Orsi et al., 2010, Klattenhoff et al., 2007)

dorsal appendage (with Df(3L)armi-J)

(Atikukke et al., 2014)

dorsal appendage | maternal effect

(Cook et al., 2004, Tomari et al., 2004)

dorsal appendage | maternal effect (with armi¹)

(Klattenhoff et al., 2009)

egg | maternal effect

(Cook et al., 2004)

microtubule organizing center & oocyte (with armi¹)

(Klattenhoff et al., 2007)

oocyte & microtubule

(Cook et al., 2004)

oocyte & microtubule organizing center

(Cook et al., 2004)

Detailed Description

Statement

Reference

None of the eggs laid by armi^72.1/Df(3L)armi-J mutant mothers have the normal number of dorsal appendages.

(Atikukke et al., 2014)

Newly eclosed armi¹/armi^72.1 transheterozygous females do not show any obvious changes in the number of germ line stem cells in the germarium, as compared to controls.

(Ma et al., 2014)

Eggs laid by armi¹/armi^72.1 females have dorsal appendage defects; 11.7% have fused dorsal appendages, 88.1% lack dorsal appendages and 0.2% have wild-type dorsal appendages.

(Orsi et al., 2010)

Only 2% of eggs derived from armi¹/armi^72.1 females have two wild-type dorsal appendages, compared with 11% if the females are fed caffeine.

(Klattenhoff et al., 2009)

armi^72.1/armi¹ eggs show fused appendages in 67.6% of cases, no appendages in 28.9% of cases and the wild-type number of appendages in 3.5% of cases.

In armi^72.1/armi¹ oocytes, both the anterior and later posterior microtubule-organizing centers are much less prominent than in wild-type oocytes.

(Klattenhoff et al., 2007)

armi^72.1 and armi^72.1/Df(3L)E1 flies have a deficient long-term olfactory memory but show no defects in short-term olfactory memory.

(Ashraf et al., 2006)

92% of eggs laid by armi^72.1 females completely lack dorsal appendages (indicating strong dorsal/ventral patterning defects) and 35% of these are also collapsed. The anterior microtubule organising center (MTOC) forms in stage 1 armi^72.1 oocytes. However, during stages 2-7 a posterior MTOC is not apparent in the mutant oocyte and microtubule levels in the oocyte and nurse cells are comparable, in contrast to wild-type egg chambers where the oocyte is enriched in microtubules compared to the nurse cells during these stages. Cortical microtubules persist at the posterior cortex of mid-oogenesis stage mutant oocytes, in contrast to wild type.

(Cook et al., 2004)

45% of progeny derived from homozygous males mated to wild-type females hatch. 92% of eggs derived from armi^72.1 females lack dorsal appendages.

(Tomari et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

armi^72.1/armi¹ has lethal | maternal effect | embryonic stage phenotype, non-suppressible by lok^p6/lok^p6

(Orsi et al., 2010)

Enhancer of

Statement

Reference

armi^72.1 is an enhancer of majority die during first instar larval stage phenotype of Gas41^f05565

(Gandhi et al., 2015)

armi^72.1 is an enhancer of melanotic necrosis | adult stage phenotype of Gas41^f05565

(Gandhi et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

armi^72.1/Df(3L)armi-J has dorsal appendage phenotype, suppressible by lok^p6

(Atikukke et al., 2014)

armi^72.1/armi¹ has dorsal appendage phenotype, suppressible | partially by lok^p6/lok^p6

(Orsi et al., 2010)

armi^72.1/armi¹ has dorsal appendage | maternal effect phenotype, suppressible | partially by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2009)

armi^72.1/armi¹ has dorsal appendage phenotype, suppressible by lok^p6/lok^p6

(Klattenhoff et al., 2007)

armi^72.1/armi¹ has dorsal appendage phenotype, suppressible | partially by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2007)

armi^72.1/armi¹ has microtubule organizing center & oocyte phenotype, suppressible by lok^p6/lok^p6

(Klattenhoff et al., 2007)

armi^72.1/armi¹ has microtubule organizing center & oocyte phenotype, suppressible by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2007)

NOT suppressed by

Statement

Reference

armi^72.1/armi¹ has dorsal appendage phenotype, non-suppressible by mei-W68¹/mei-W68^k05603

(Klattenhoff et al., 2007)

Enhancer of

Statement

Reference

armi^72.1 is an enhancer of scutum phenotype of Gas41^f05565

(Gandhi et al., 2015)

armi^72.1 is an enhancer of scutellum phenotype of Gas41^f05565

(Gandhi et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The mortality of Gas41^f05565 homozygotes as well as the necrotic patches (on scutum, notum and scutellum) observed in the surviving adults is further enhanced by combination with armi^72.1.

(Gandhi et al., 2015)

lok^p6 partially suppresses the dorsal appendage defects seen in eggs produced by armi^72.1/Df(3L)armi-J mutant mothers. The number of eggs produced is also significantly increased.

(Atikukke et al., 2014)

The dorsal appendage defects seen in eggs laid by armi¹/armi^72.1 females are partly suppressed if the females are also homozygous for lok^p6; 16.1% of the eggs have fused dorsal appendages, 7.3% lack dorsal appendages and 76.6% have wild-type dorsal appendages.

(Orsi et al., 2010)

56% of eggs derived from mei-41^D3/mei-41^D3 ; armi¹/armi^72.1 double mutant females have normal dorsal appendages, but the fraction of embryos with normal dorsal appendages increases to 83% if the females are fed caffeine.

(Klattenhoff et al., 2009)

The fused dorsal appendage phenotype of armi^72.1/armi¹ eggs is suppressed in lok^p6; armi^72.1/armi¹ eggs with 92% of double mutants showing wild-type appendage morphology.

The mei-41^D3 mutation partially suppresses the fused dorsal appendage phenotype of armi^72.1/armi¹ eggs; 56% of mei-41^D3; armi^72.1/armi¹ eggs show wild-type appendage morphology.

The fused dorsal appendage phenotype of armi^72.1/armi¹ eggs is not suppressed in mei-W68¹/mei-W68^k05603; armi^72.1/armi¹ eggs.

The microtubule-organizing center phenotype of armi^72.1/armi¹ oocytes is suppressed by the lok^p6 mutation.

The microtubule-organizing center phenotype of armi^72.1/armi¹ oocytes is partially suppressed by the mei-41^D3 mutation.

(Klattenhoff et al., 2007)

armi^72.1 osk¹ double mutant ovaries have microtubule defects that are cytologically identical to the armi single mutant phenotype.

(Cook et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

armi^72.1/armi¹ is rescued by Scer\GAL4^{VP16.nanos.UTR}/armi^UASp.EGFP