FlyBase Allele Report: Dmel\aPKC[psu417]

General Information

Symbol

Dmel\aPKC^psu417

Species

D. melanogaster

Name

FlyBase ID

FBal0155671

Feature type

allele

Associated gene

Dmel\aPKC

Associated Insertion(s)

Carried in Construct

Also Known As

2R-417-13

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Luschnig et al., 2004, Luschnig et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: G347N.

(Kim et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:14,948,276..14,948,276 [-]

Nucleotide change:

G14948276A

Amino acid change:

Reported amino acid change:

G347N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kim et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with aPKC^k06403)

(Kim et al., 2009)

lethal (with aPKC^psu69)

(Kim et al., 2009)

lethal (with aPKC^psu265)

(Kim et al., 2009)

lethal (with Df(2R)Jp1)

(Kim et al., 2009)

lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive

(Luschnig et al., 2004, Luschnig et al., 2004)

lethal | larval stage | recessive

(Luschnig et al., 2004)

lethal | recessive

(Luschnig et al., 2004)

lethal - all die before end of second instar larval stage | recessive

(Kim et al., 2009)

partially lethal - majority die (with aPKC^psu141)

(Kim et al., 2009)

some die during second instar larval stage | recessive

(Kim et al., 2009)

Phenotype Manifest In

embryonic/first instar larval cuticle | germline clone | maternal effect

(Luschnig et al., 2004)

embryonic/larval cuticle | germline clone | maternal effect

(Kim et al., 2009)

Detailed Description

Statement

Reference

Occasional aPKC^psu69/aPKC^psu417, aPKC^psu265/aPKC^psu417 and aPKC^k06403/aPKC^psu417 adult escapers are seen.

Embryos derived from homozygous female germ-line clones have cuticle defects, although contiguous patches of cuticle and remnants of denticle belts are seen.

Homozygous follicle cell clones show a normal monolayered tissue structure. Oocyte determination occurs normally in homozygous germ-line clones.

(Kim et al., 2009)

Embryos derived from females carrying homozygous germ line clones produce just small pieces of cuticle and Filzkorper material.

(Luschnig et al., 2004)

Embryos derived from females carrying homozygous germ line clones fail to produce a coherent cuticle. Homozygotes die at the late second larval instar.

(Luschnig et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

2R-417-13

(Kim et al., 2009, Luschnig et al., 2004)

aPKC^2R-417-13

aPKC⁴¹⁷

(Bell et al., 2015)

aPKC^psu417

(Bell et al., 2015, Fletcher et al., 2012, Kim et al., 2009)

psu^2R-417-13

(Luschnig et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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