FlyBase Allele Report: Dmel\VGlut[UAS.cDa]

The expression of VGlut^UAS.cDa under the control of Scer\GAL4^VGlut-OK371 induces synaptic transmission defects in the larval muscle 6/7 NMJ: recordings conditions with extracellular Cl show an increase in mEPSP and mEPSC amplitudes, decreased quantal content, increased failure rate and no paired-pulse depression; recording conditions without extracellular Cl also increase in mEPSC and EPSC amplitudes and unaffected quantal content.

(Li et al., 2021)

Larvae expressing VGlut^UAS.cDa under the control of Scer\GAL4^VGlut-OK371 have defective neuromuscular junction neurotransmission: increased mEJP amplitude and decreased quantal content, but unaffected EJP amplitudes.

(Gratz et al., 2019)

The expression of VGlut^Scer\UAS.cDa under the control of Scer\GAL4^VGlut-OK371 leads to larval neuromuscular junctions under 0.4mM extracellular Ca[2+] concentration conditions exhibiting a significant increase in miniature excitatory postsynaptic potentials and a reciprocal significant decrease in quantal contents, but no obvious changes in evoked excitatory postsynaptic potentials, as compared to controls. Under 0.2mM extracellular Ca[2+] concentration conditions, these neuromuscular junctions exhibit significant decreases in evoked excitatory postsynaptic potentials and quantal contents, as compared to controls.

(Kiragasi et al., 2017)

Intracellular voltage recordings in muscles of animals overexpressing VGlut^Scer\UAS.cDa driven by Scer\GAL4^VGlut.PD or Scer\GAL4^BG380 reveal large spontaneous events in motoneurons.

Driving VGlut^Scer\UAS.cDa withe the strong Scer\GAL4^BG380 driver results in death during larval stages.

Driving VGlut^Scer\UAS.cDa with Scer\GAL4^VGlut.PD results in lethality within the first few weeks of adulthood.

Flies overexpressing VGlut^Scer\UAS.cDa driven by Scer\GAL4^VGlut.PD are uncoordinated and cannot fly. VGlut^Scer\UAS.cDa-overexpressing flies display progressive motor defects manifesting in impaired negative geotaxis.

(Daniels et al., 2011)

Expression of VGlut^Scer\UAS.cDa in post-mitotic neurons under the control of Scer\GAL4^elav-C155 causes a significant increase in average mEPSP amplitude. There is also a homeostatic decrease in presynaptic quantal content in these mutants.

(Marie et al., 2010)

Males expressing VGlut^Scer\UAS.cDa under the control of Scer\GAL4^αTub84B.PL show high levels of homosexual courtship, which includes all aspects of sexual behaviour (including singing, genital licking and attempted copulation). Occasionally, the males attempt copulation with inappropriate body reions, such as the head.

Males expressing VGlut^Scer\UAS.cDa under the control of Scer\GAL4^NP0225 show a significant amount of homosexual behaviour, although less than seen when the Scer\GAL4^αTub84B.PL driver is used.

Expression of VGlut^Scer\UAS.cDa under the control of Scer\GAL4^Mef2.247 has no affect on the courtship behaviour of males.

(Grosjean et al., 2008)

Expression of VGlut^Scer\UAS.cDa under the control of Scer\GAL4^BG380 results in an increase of about 60% in the mean mEJP amplitude recorded from the muscle of the larval neuromuscular junction compared to wild type. The amplitude of the entire population of mEJP events seems to be increased in size, with the median amplitude increasing by 35% compared to wild type. There is a small increase in mEJP frequency. Larvae expressing VGlut^Scer\UAS.cDa under the control of Scer\GAL4^BG380 show no significant difference in the amplitude of evoked EJPs recorded from the muscle of the larval neuromuscular junction compared to wild type. Quantal content is decreased relative to wild type. Larvae expressing VGlut^Scer\UAS.cDa under the control of Scer\GAL4^BG380 show an increase in synaptic vesicle size (assayed at the neuromuscular junction of the type Ib motorneuron that innervates muscles 6 and 7) compared to wild type; a 14% increase in mean vesicle outer diameter and a median increase in vesicle outer diameter of 10% is seen.

(Daniels et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, enhanceable by KaiR1D^MB01010/KaiR1D^MB01010

(Kiragasi et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, VGlut^UAS.cDa has abnormal neurophysiology phenotype, non-enhanceable by Scer\GAL4^elav-C155/gsb^491.RNAi.UAS

(Marie et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, suppressible by GluClα^MI02890

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, suppressible by GluClα^glc1/Df(3R)BSC809

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, suppressible by GluClα^{MI02890-FlpStop.D}

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, suppressible by Df(3R)BSC809/GluClα^MI02890

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, suppressible by GluClα^KK109167, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

NOT suppressed by

Statement

Reference

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by KaiR1D^f03502

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Grik^MB05324

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Nmdar1^XC3/Nmdar1^XC1

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Nmdar2^YH7/Nmdar2^YH9

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by mGluR^NP6701

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by mGluR^112b

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Nmdar2^YH7

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by CG11155^GD4652, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by GluRIB^JF02752, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Scer\GAL4^VGlut-OK371/clumsy^JF02987

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by GluRIA^JF02671, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Ekar^JF03126, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Nmdar1^JF01961, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Nmdar2^JF02044, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Nmdar2^HMS02012, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Grik^JF01840, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gαf^JF01950, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gαo^JF02844, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gαi^JF01608, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gαi^HMS01273, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gαq^JF02390, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gβ76C^JF03127, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gαs^HMC03106, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has abnormal neurophysiology | larval stage phenotype, non-suppressible by Gγ1^JF01954, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^elav-C155, VGlut^UAS.cDa has abnormal neurophysiology phenotype, non-suppressible by Scer\GAL4^elav-C155/gsb^491.RNAi.UAS

(Marie et al., 2010)

Enhancer of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is an enhancer of abnormal neurophysiology | larval stage phenotype of GluRIIA^Q615R, GluRIIB^SP5

(Han et al., 2023)

VGlut^UAS.cDa, Scer\GAL4^VGlut-OK371 is an enhancer of abnormal neurophysiology | larval stage phenotype of KaiR1D^MB01010, Scer\GAL4^VGlut-OK371

(Kiragasi et al., 2017)

NOT Enhancer of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-enhancer of abnormal neurophysiology | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Suppressor of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a suppressor | partially of abnormal neurophysiology | larval stage phenotype of GluRIIA^PV3

(Han et al., 2023)

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-suppressor of abnormal neurophysiology | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction | larval stage phenotype, enhanceable by KaiR1D^MB01010/KaiR1D^MB01010

(Kiragasi et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, VGlut^UAS.cDa has neuromuscular junction phenotype, non-enhanceable by Scer\GAL4^elav-C155/gsb^491.RNAi.UAS

(Marie et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, suppressible by GluClα^MI02890

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, suppressible by GluClα^MI02890

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, suppressible by GluClα^glc1/Df(3R)BSC809

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, suppressible by Df(3R)BSC809/GluClα^MI02890

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, suppressible by GluClα^{MI02890-FlpStop.D}

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, suppressible by GluClα^glc1/Df(3R)BSC809

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, suppressible by Df(3R)BSC809/GluClα^MI02890

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, suppressible by GluClα^{MI02890-FlpStop.D}

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, suppressible by GluClα^KK109167, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, suppressible by GluClα^KK109167, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

NOT suppressed by

Statement

Reference

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by mGluR^NP6701

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by mGluR^112b

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Nmdar2^YH7

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by mGluR^NP6701

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Nmdar2^YH7/Nmdar2^YH9

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Nmdar1^XC3/Nmdar1^XC1

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by CG11155^GD4652, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by GluRIB^JF02752, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Nmdar2^JF02044, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Nmdar2^HMS02012, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by KaiR1D^f03502

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Scer\GAL4^VGlut-OK371/clumsy^JF02987

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Ekar^JF03126, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by GluRIA^JF02671, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Nmdar1^JF01961, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Nmdar2^JF02044, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Ekar^JF03126, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Nmdar2^HMS02012, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Nmdar1^JF01961, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by GluRIB^JF02752, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by GluRIA^JF02671, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by KaiR1D^f03502

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Scer\GAL4^VGlut-OK371/clumsy^JF02987

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by CG11155^GD4652, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Grik^JF01840, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Grik^JF01840, Scer\GAL4^VGlut-OK371

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Grik^MB05324

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage phenotype, non-suppressible by Grik^MB05324

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Nmdar2^YH7/Nmdar2^YH9

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by mGluR^112b

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Nmdar2^YH7

(Li et al., 2021)

Scer\GAL4^VGlut-OK371, VGlut^UAS.cDa has embryonic/larval neuromuscular junction phenotype, non-suppressible by Nmdar1^XC3/Nmdar1^XC1

(Li et al., 2021)

Scer\GAL4^elav-C155, VGlut^UAS.cDa has neuromuscular junction phenotype, non-suppressible by Scer\GAL4^elav-C155/gsb^491.RNAi.UAS

(Marie et al., 2010)

Enhancer of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is an enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^Q615R, GluRIIB^SP5

(Han et al., 2023)

VGlut^UAS.cDa, Scer\GAL4^VGlut-OK371 is an enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of KaiR1D^MB01010, Scer\GAL4^VGlut-OK371

(Kiragasi et al., 2017)

NOT Enhancer of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-enhancer of type Ib motor neuron | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-enhancer of type Is motor neuron | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-enhancer of motor neuron | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Suppressor of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^PV3

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a suppressor | partially of motor neuron | larval stage phenotype of GluRIIA^PV3

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a suppressor | partially of type Ib motor neuron | larval stage phenotype of GluRIIA^PV3

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a suppressor | partially of type Is motor neuron | larval stage phenotype of GluRIIA^PV3

(Han et al., 2023)

Scer\GAL4^elav.PU/VGlut^UAS.cDa is a suppressor | partially of NMJ bouton | third instar larval stage phenotype of Mon1^Δ181

(Deivasigamani et al., 2015)

Scer\GAL4^elav-C155/VGlut^UAS.cDa is a suppressor | partially of NMJ bouton | third instar larval stage phenotype of Mon1^Δ181/Df(2L)Exel9062

(Deivasigamani et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-suppressor of type Ib motor neuron | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-suppressor of type Is motor neuron | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Scer\GAL4^VGlut-OK371/VGlut^UAS.cDa is a non-suppressor of motor neuron | larval stage phenotype of GluRIIB^SP5

(Han et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased evoked excitatory postsynaptic potentials and quantal contents under 0.2mM extracellular Ca[2+] concentration conditions observed at the larval neuromuscular junctions of individuals either expressing VGlut^Scer\UAS.cDa under the control of Scer\GAL4^VGlut-OK371 or homozygous for KaiR1D^MB01010 are enhanced in double mutants. The increased miniature excitatory postsynaptic potentials and the reciprocal decreased quantal contents under 0.4mM extracellular Ca[2+] concentration conditions observed at the larval neuromuscular junctions of individuals expressing VGlut^Scer\UAS.cDa under the control of Scer\GAL4^VGlut-OK371, however, are not significantly altered by KaiR1D^MB01010 homozygosity.

(Kiragasi et al., 2017)

Scer\GAL4^elav-C155 overexpression of VGlut^Scer\UAS.cDa significantly decreases the number of satellite boutons seen in Mon1^Δ181/Df(2L)Exel9062 third instar larvae. Scer\GAL4^elav.PU overexpression of VGlut^Scer\UAS.cDa significantly decreases the number of satellite boutons seen in Mon1^Δ181/Mon1^Δ181 third instar larvae.

(Deivasigamani et al., 2015)

Expression of VGlut^Scer\UAS.cDa and gsb^{491.dsRNA.Scer\UAS} in post-mitotic neurons under the control of Scer\GAL4^elav-C155 causes a significant increase in average mEPSP amplitude. There is also a homeostatic decrease in presynaptic quantal content in these mutants.

(Marie et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^BG380/VGlut^UAS.cDa rescues Df(2L)VGlut²/VGlut¹

(Daniels et al., 2006)

Comments

Expression of VGlut^Scer\UAS.cDa in motor neurons under the control of Scer\GAL4^BG380 rescues the decrease in mEJP frequency in VGlut¹/Df(2L)VGlut² mutant synapses. These larvae exhibit a slight increase in quantal size compared to controls.

(Daniels et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81119

w^*; P{UAS-VGlut.D}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

VGlut^Scer\UAS.cDa

VGlut^UAS.cDa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Daniels

(Daniels et al., 2004)

Secondary FlyBase IDs

References (16)

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