FB2024_03 , released June 25, 2024
Allele: Dmel\sun2
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General Information
Symbol
Dmel\sun2
Species
D. melanogaster
Name
FlyBase ID
FBal0177595
Feature type
allele
Associated gene
Dmel\sun
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kidd et al., 2005)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Kidd et al., 2005)

Amino acid replacement: W4term.

(Kidd et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,849,153..15,849,153 [-]
Nucleotide change:

G15849153A

Reported nucleotide change:

G?A

Amino acid change:

W4term | sun-PA; W4term | sun-PB

Reported amino acid change:

W4term

Comment:

TGG to TGA

(Kidd et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant larvae show greatly delayed larval growth.

      (Kidd et al., 2005)

      sun2/+ female flies exhibit an extended lifespan compared with the parental strain (51% increase in average lifespan). At day 6, mortality is minimal for both parental and sun2/+ females. At day 30, the mortality rate diverges significantly between parental and sun2/+ females. No difference in ATP concentrations is observed between the parental and sun2/+ mutant females. As compared to the parental strain, sun2/+ females exhibit an increase in resistance to 20mM dietary paraquat (a free radical generator).

      (Cvejic et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sun1

      (Kidd et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sun2
      sunY6
      (Cvejic et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)