FB2024_03 , released June 25, 2024
Allele: Dmel\PofD2
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General Information
Symbol
Dmel\PofD2
Species
D. melanogaster
Name
FlyBase ID
FBal0182224
Feature type
allele
Associated gene
Dmel\Pof
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Larsson et al., 2004)
Progenitor genotype
P{EP}PofEP2285
(Larsson et al., 2004)
Caused by aberration
Df(3R)D2
Cytology
Description

Imprecise excision of the P{EP} element, resulting in a deletion that removes the promoter region of Pof.

(Larsson et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PofD2/PofD119 individuals show haplo-4th chromosome specific lethality.

      (Johansson et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      The lethality of the Df(3R)D2 deletion chromosome (which affects both Pof and CG33228 transcription units) is caused by an effect on CG33228 (represented by the CG33228D2 allele) and not by an effect on Pof; transheterozygotes of CG33228D2 with either CG33228CB-6312-3 or CG33228SH0542 (two alleles caused by insertions within the CG33228 open reading frame) are lethal, whereas newly generated excision alleles that only affect the Pof transcription unit and not the CG33228 transcription unit are viable.

      (Johansson et al., 2007)

      FlyBase curator comment: the lethality of the Df(3R)D2 deletion chromosome has been shown (see FBrf0202200) to be due to an effect on CG33228 (represented by the CG33228D2 allele) and not due to an effect on Pof as originally reported in FBrf0179298.

      (Larsson et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PofD2
      PofΔ2
      Δ2
      (Larsson et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)