FB2024_03 , released June 25, 2024
Allele: Dmel\Desat11573-F7
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General Information
Symbol
Dmel\Desat11573-F7
Species
D. melanogaster
Name
FlyBase ID
FBal0190633
Feature type
allele
Associated gene
Dmel\Desat1
Associated Insertion(s)
P{?GawB}Desat11573-F7
Carried in Construct
Also Known As
F7
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Marcillac et al., 2005)
Progenitor genotype
Desat11573-1
(Marcillac et al., 2005)
Associated Insertion(s)
P{?GawB}Desat11573-F7
Cytology
Description

Imprecise excision of the P{GawB} element, approximately 0.1kb of the insertion remains. The surrounding desat1 locus has not been altered by the excision.

(Marcillac et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The total amount of cuticular hydrocarbons is the same in mutant and control males. The mutant males show a significant decrease in the relative proportion of desaturated cuticular hydrocarbons and a significant increase in the relative proportion of methyl branched cuticular hydrocarbons compared to control males.

      The total amount of cuticular hydrocarbons is the same in mutant and control females. The mutant females show a significant decrease in the relative proportion of desaturated cuticular hydrocarbons and a significant increase in the relative proportion of linear cuticular hydrocarbons compared to control females.

      Homozygous males retain an ability to discriminate between male and female control flies in a courtship assay.

      (Houot et al., 2010)

      Mutant females have defective cuticular hydrocarbon (CH) profiles; the desaturation index (DI) in females is significantly different from both wild-type controls and the desat11573-1 progenitor allele.

      (Marcillac et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Desat11573-F7
      F7
      (Houot et al., 2010, Marcillac et al., 2005)
      S1
      (Houot et al., 2010)
      desat11573-F7
      Name Synonyms
      Secondary FlyBase IDs
        References (2)