FlyBase Allele Report: Dmel\yki[UAS.cHa]

The expression of yki^UAS.cHa under the control of Scer\GAL4^ptc.PU, Scer\GAL4^hh.PU and Scer\GAL4^nub.PU leads to an expansion of the anterior-posterior boundary region of the wing disc, the posterior region of the wing disc and the full wing pouch, respectively.

(Ahmad et al., 2021)

The expression of yki^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] leads to the third instar larval wing disc dorsal compartment presenting a significant increase in size, but does not lead to polyploidy/aneuploidy or epithelial organization defects (i.e. cells show normal sub-cellular localization of Discs large protein), as compared to controls; these larvae eventually enter pupariation but die as pupae. Expression under the control of either Scer\GAL4^hh.PU or Scer\GAL4^e22c also leads to a larger third instar larval wing disc posterior compartment, as compared to controls.

(Gerlach et al., 2018)

Overexpression of yki^Scer\UAS.cHa driven in the fat body of male flies by Scer\GAL4^r4 (or driven by Scer\GAL4^yolk in female fat bodies) significantly decreases survival of flies in response to Gram-positive bacteria (Staphylococcus aureus or Enterococcus faecalis) and a fungus (Aspergillus fumigatus), compared to controls; expression with Scer\GAL4^r4 in males has no effect on survival in response to Gram-negative bacteria (Erwinia carotovora carotovora 15 or Escherichia coli). Bacterial load (measured as colony forming units 24hr post infection) of S. aureus (but not Erwinia carotovora carotovora 15) significantly increases in adult flies, compared to controls.

(Liu et al., 2016)

Third instar larvae expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^RapGAP1-OK6 show normal number of satellite boutons on neuromuscular junctions relative to controls.

(Sakuma et al., 2016)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^C587 has no apparent germarium phenotype.

(Li et al., 2015)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^en.PU in third instar larvae leads to increased area of the posterior compartment of the wing disc.

(Zhang et al., 2015)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PU leads to increased eye size.

(Qing et al., 2014)

Eye disc clones expressing yki^Scer\UAS.cHa exhibit tissue overgrowth.

(Koontz et al., 2013)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PU results in a disorganised eye that is overgrown.

(Schoenherr et al., 2012)

Overexpression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in overgrown adult eyes.

Overexpression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in ectopic proliferation in the GMR region posterior to the second mitotic wave, while little apoptosis is seen in the eye-antennal disc.

(Verghese et al., 2012)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF during the adult stage (using the a temperature-sensitive Scer\GAL80 line to control the timing of expression) results in unequivocal, albeit weak, progressive degeneration of photoreceptor cells.

(Napoletano et al., 2011)

Expression of yki^Scer\UAS.cHa in wild-type tissue results in a mild overgrowth phenotype.

(Willecke et al., 2011)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in overgrowth of the eye.

(Baumgartner et al., 2010)

Pupal eye clones of cells overexpressing yki^Scer\UAS.cHa driven by Scer\GAL4^αTub84B.PL exhibit increased clonal area as well as overproliferation of interommatidial cells.

(Das Thakur et al., 2010)

Wing disc clones expressing yki^Scer\UAS.cHa (under the control of Scer\GAL4^tub.PU) are large in size. Adjacent wild-type clones are much reduced in size compared to control sibling clones.

Wing disc clones expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP are large in size compared to control clones.

(Neto-Silva et al., 2010)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in increased eye size compared to controls.

(Yu et al., 2010)

Mosaic clones expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^αTub84B.PP are notably larger than their wild-type twins in wing discs dissected either at 60 hours or 48 hours after heat-shock induction. Furthermore yki^Scer\UAS.cHa-wild-type twins almost disappear from the epithelium at 120 hours after egg laying. These differences in size are also prominent when discs are dissected at 96 hours after egg laying. The clonal expansion of yki^Scer\UAS.cHa-expressing clones is correlated with non-autonomous apoptosis. The size advantage of yki^Scer\UAS.cHa clones and the induction of apoptosis in wild-type cells indicates cell competition.

(Ziosi et al., 2010)

Adherens junctions of wing disc cells expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^en-e16E are 1.78 times wider than those of wild-type control cells in the same disc.

(Genevet et al., 2009)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in overgrown eyes.

(Oh and Irvine, 2008)

Expression of yki^Scer\UAS.cHa in the germline, under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or Scer\GAL4^{bam.T:Hsim\VP16}, does not result in germline over-proliferation in testes or ovarioles.

(Sun et al., 2008)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in increased eye size compared to controls.

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU in clones in the eye disc results in enlarged and round-shaped clones.

(Wu et al., 2008)

Overexpression

of yki^Scer\UAS.cHa in the developing eye, driven by Scer\GAL4^GMR.PF, results in the generation of excess interommatidial pigment and bristle cells. Wild-type retinae have 1.67 cells in regions corresponding to one side of an

ommatidial hexagon between two vertices, while Scer\GAL4^GMR.PF>yki^Scer\UAS.cHa retinae have 5.9 cells in the same region.

(Nolo et al., 2006)

Clones in the wing disc that express yki^Scer\UAS.cHa under the control of Scer\GAL4^tub grow much larger than wild-type controls. These clones cause the epithelium to bulge apically, due to a change in cell morphology in which nuclei move to a more apical position.

(Thompson and Cohen, 2006)

Expression of yki in the wing disc, under the control of Scer\GAL4^hh-Gal4 results in an overgrowth of the posterior compartment.

(Willecke et al., 2006)

Clones in the eye imaginal disc expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP fail to undergo cell-cycle arrest posterior to the second mitotic wave and continue the cell cycle. Cell death is significantly suppressed in the clones, even though abundant apoptosis is detected in neighbouring wild-type cells. Ommatidial clusters expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP have the normal complement of photoreceptor cells. The spacing between adjacent ommatidial clusters is increased due to the presence of extra interommatidial cells. The formation of extra interommatidial cells is most evident in pupal eye discs, where the clones contain many additional cells between photoreceptor clusters.

Clones expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP lead to marked overgrowth in adult epithelial structures. Wing imaginal discs containing multiple clones can reach up to eight times the area of control wing discs raised under identical conditions. Adult cuticles secreted by cells expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP display an unusual texture.

Wing imaginal disc cells expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP multiply faster than wild-type cells (a cell-doubling time of 12.0 hours compared to 16.1 hours in wild-type). These cells also minimize their contact with other cells and form round smooth cell borders. Cells expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PP have a similar cell cycle profile and cell size distribution as compared to wild-type cells.

(Huang et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by Scer\GAL4^ap-md544/pnut^GD1512

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has neoplasia | third instar larval stage phenotype, enhanceable by bsk^DN.UAS/Scer\GAL4^ap-md544

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by dia^HMS00308/Scer\GAL4^ap-md544

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by Scer\GAL4^ap-md544/chb^HMS01146

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by Scer\GAL4^ap-md544/pbl^JF02979

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by Incenp^GD7511, Scer\GAL4^ap-md544

(Gerlach et al., 2018)

Scer\GAL4^hh.PU, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by Scer\GAL4^hh.PU/pnut^GD1512

(Gerlach et al., 2018)

Scer\GAL4^hh.PU, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, enhanceable by Scer\GAL4^e22c/pnut^GD1512

(Gerlach et al., 2018)

Scer\GAL4^Tub.PU, yki^UAS.cHa has visible phenotype, enhanceable by Smurf[+]/Smurf^15C

(Cao et al., 2014)

Scer\GAL4^Tub.PU, yki^UAS.cHa has abnormal size phenotype, enhanceable by Smurf[+]/Smurf^15C

(Cao et al., 2014)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has increased cell size | somatic clone phenotype, enhanceable by sd^UAS.cSa/Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has hyperplasia | somatic clone phenotype, enhanceable by sd^UAS.cSa/Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^GMR.PF, yki^UAS.cHa has abnormal size phenotype, enhanceable by sd^UAS.cSa/Scer\GAL4^GMR.PF

(Wu et al., 2008)

Scer\GAL4^GMR.PF, yki^UAS.cHa has visible phenotype, enhanceable by sd^UAS.cSa/Scer\GAL4^GMR.PF

(Wu et al., 2008)

Scer\GAL4^GMR.PF, yki^UAS.cHa has abnormal size phenotype, enhanceable by Mmus\Tead2^UAS.cWa, Scer\GAL4^GMR.PF

(Wu et al., 2008)

Scer\GAL4^GMR.PF, yki^UAS.cHa has visible phenotype, enhanceable by Mmus\Tead2^UAS.cWa, Scer\GAL4^GMR.PF

(Wu et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, yki^UAS.cHa has increased size | larval stage phenotype, suppressible | partially by syd^GLC01419/Scer\GAL4^ptc.PU

(Ahmad et al., 2021)

Scer\GAL4^hh.PU, yki^UAS.cHa has increased size | larval stage phenotype, suppressible | partially by Scer\GAL4^hh.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, yki^UAS.cHa has increased size | larval stage phenotype, suppressible | partially by Scer\GAL4^nub.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^r4, yki^UAS.cHa has abnormal immune response | adult stage phenotype, suppressible by cact^HMS00084/Scer\GAL4^r4

(Liu et al., 2016)

Scer\GAL4^en.PU, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^en.PU/tai^HMS00673

(Zhang et al., 2015)

Scer\GAL4^en.PU, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^en.PU/nanos^JF02931

(Zhang et al., 2015)

Scer\GAL4^en.PU, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, suppressible | partially by piwi^HMS00606/Scer\GAL4^en.PU

(Zhang et al., 2015)

Scer\GAL4^en.PU, yki^UAS.cHa has abnormal size | third instar larval stage phenotype, suppressible | partially by Df(3R)Exel6183/nanos^L7

(Zhang et al., 2015)

Scer\GAL4^GMR.PU, yki^UAS.cHa has visible phenotype, suppressible by Ncoa6^HMS00664, Scer\GAL4^GMR.PU

(Qing et al., 2014)

Scer\GAL4^GMR.PU, yki^UAS.cHa has visible phenotype, suppressible by trr^HMS01019/Scer\GAL4^GMR.PU

(Qing et al., 2014)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has hyperplasia | somatic clone phenotype, suppressible | partially by sd^GD4744/Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has hyperplasia | somatic clone phenotype, suppressible by Myc^GD1419, Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has hyperplasia | somatic clone phenotype, suppressible by Myc^αTub84B.PBb, Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has increased cell size | somatic clone phenotype, suppressible by Myc^αTub84B.PBb, Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^αTub84B.PP, yki^UAS.cHa has increased cell size | somatic clone phenotype, suppressible by Myc^PL35/Myc^αTub84B.PBb, Scer\GAL4^αTub84B.PP

(Ziosi et al., 2010)

Scer\GAL4^GMR.PF, yki^UAS.cHa has abnormal size phenotype, suppressible by sd[+]/sd¹²

(Wu et al., 2008)

Scer\GAL4^GMR.PF, yki^UAS.cHa has visible phenotype, suppressible by sd[+]/sd¹²

(Wu et al., 2008)

Scer\GAL4^Tub.PU, yki^UAS.cHa has increased cell size | somatic clone phenotype, suppressible by Df(3L)mir-ban^Δ1

(Thompson and Cohen, 2006)

NOT suppressed by

Statement

Reference

Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa has neoplasia | somatic clone phenotype, non-suppressible by Scer\GAL4^Tub.PU/hth^HMS01112

(Khan et al., 2013)

Scer\GAL4^GMR.PF, yki^UAS.cHa has visible phenotype, non-suppressible by kibra^EP747/Scer\GAL4^GMR.PF

(Genevet et al., 2010)

Enhancer of

Statement

Reference

yki^UAS.cHa/Scer\GAL4^ap-md544 is an enhancer of abnormal mitotic cell cycle | third instar larval stage phenotype of Scer\GAL4^ap-md544, pnut^GD1512

(Gerlach et al., 2018)

yki^UAS.cHa/Scer\GAL4^ey.PH is an enhancer of abnormal planar polarity | adult stage | somatic clone phenotype of Scer\GAL4^ey.PH, dachs^GC13, ft^G-rv

(Brittle et al., 2012)

yki^UAS.cHa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} is an enhancer of neoplasia phenotype of Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689

(Willecke et al., 2011)

yki^UAS.cHa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} is an enhancer of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Suppressor of

Statement

Reference

yki^UAS.cHa/Scer\GAL4^C587 is a suppressor | partially of neoplasia | female | adult stage phenotype of Scer\GAL4^C587, vg^UAS.cKa

(Li et al., 2015)

yki^UAS.cHa/Scer\GAL4^C587 is a suppressor | partially of neoplasia | female | adult stage phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}

(Li et al., 2015)

yki^UAS.cHa/Scer\GAL4^C587 is a suppressor | partially of neoplasia | female | adult stage phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa

(Li et al., 2015)

yki^UAS.cHa/Scer\GAL4^Tub.PU is a suppressor | partially of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of Scer\GAL4^Tub.PU, l(2)gl⁴, vg^UAS.cKa

(Khan et al., 2013)

yki^UAS.cHa/Scer\GAL4^GMR.PU is a suppressor of visible phenotype of hid^GMR.PG

(Schoenherr et al., 2012)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Verghese et al., 2012)

yki^UAS.cHa/Scer\GAL4^Tub.PU is a suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of ft⁸

(Napoletano et al., 2011)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of lethal phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cWa

(Huang et al., 2005)

Other

Statement

Reference

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has neoplasia | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has abnormal developmental rate phenotype

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has increased body size | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has abnormal cell polarity | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^hh.PU, pnut^GD1512, yki^UAS.cHa has abnormal cell adhesion | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa has neoplasia | somatic clone phenotype

(Khan et al., 2013)

Scer\GAL4^GMR.PU, hid^GMR.PG, yki^UAS.cHa has abnormal eye color phenotype

(Schoenherr et al., 2012)

Dronc^pro.UAS, Scer\GAL4^GMR.PF, yki^UAS.cHa has increased cell death phenotype

(Verghese et al., 2012)

Scer\GAL4^αTub84B.PP, sd^GD4744, yki^UAS.cHa has increased cell size | somatic clone phenotype

(Ziosi et al., 2010)

Myc^GD1419, Scer\GAL4^αTub84B.PP, yki^UAS.cHa has decreased cell number | somatic clone phenotype

(Ziosi et al., 2010)

Myc^αTub84B.PBb, Myc^PL35, Scer\GAL4^αTub84B.PP, yki^UAS.cHa has decreased cell size phenotype

(Ziosi et al., 2010)

Scer\GAL4^GMR.PF, sd^UAS.cSa, yki^UAS.cHa has abnormal eye color phenotype

(Wu et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, yki^UAS.cHa has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Scer\GAL4^ap-md544/pnut^GD1512

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has wing disc | third instar larval stage phenotype, enhanceable by bsk^DN.UAS/Scer\GAL4^ap-md544

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by dia^HMS00308/Scer\GAL4^ap-md544

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Scer\GAL4^ap-md544/chb^HMS01146

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Scer\GAL4^ap-md544/pbl^JF02979

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, yki^UAS.cHa has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Incenp^GD7511, Scer\GAL4^ap-md544

(Gerlach et al., 2018)

Scer\GAL4^hh.PU, yki^UAS.cHa has wing disc posterior compartment | third instar larval stage phenotype, enhanceable by Scer\GAL4^hh.PU/pnut^GD1512

(Gerlach et al., 2018)

Scer\GAL4^hh.PU, yki^UAS.cHa has wing disc posterior compartment | third instar larval stage phenotype, enhanceable by Scer\GAL4^e22c/pnut^GD1512

(Gerlach et al., 2018)

Scer\GAL4^Tub.PU, yki^UAS.cHa has eye phenotype, enhanceable by Smurf[+]/Smurf^15C

(Cao et al., 2014)

Scer\GAL4^GMR.PF, yki^UAS.cHa has eye phenotype, enhanceable by sd^UAS.cSa/Scer\GAL4^GMR.PF

(Wu et al., 2008)

Scer\GAL4^GMR.PF, yki^UAS.cHa has eye phenotype, enhanceable by Mmus\Tead2^UAS.cWa, Scer\GAL4^GMR.PF

(Wu et al., 2008)

NOT Enhanced by

Statement

Reference

Scer\GAL4^αTub84B.PL, yki^UAS.cHa has eye | pupal stage | somatic clone phenotype, non-enhanceable by Df(1)jub^I, Scer\GAL4^αTub84B.PL

(Das Thakur et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, yki^UAS.cHa has anterior-posterior compartment boundary of the wing disc phenotype, suppressible | partially by syd^GLC01419/Scer\GAL4^ptc.PU

(Ahmad et al., 2021)

Scer\GAL4^nub.PU, yki^UAS.cHa has wing disc phenotype, suppressible | partially by Scer\GAL4^nub.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^hh.PU, yki^UAS.cHa has wing disc posterior compartment phenotype, suppressible | partially by Scer\GAL4^hh.PU/syd^GLC01419

(Ahmad et al., 2021)

Scer\GAL4^en.PU, yki^UAS.cHa has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^en.PU/tai^HMS00673

(Zhang et al., 2015)

Scer\GAL4^en.PU, yki^UAS.cHa has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^en.PU/nanos^JF02931

(Zhang et al., 2015)

Scer\GAL4^en.PU, yki^UAS.cHa has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by piwi^HMS00606/Scer\GAL4^en.PU

(Zhang et al., 2015)

Scer\GAL4^en.PU, yki^UAS.cHa has wing disc posterior compartment | third instar larval stage phenotype, suppressible | partially by Df(3R)Exel6183/nanos^L7

(Zhang et al., 2015)

Scer\GAL4^GMR.PU, yki^UAS.cHa has eye phenotype, suppressible by Ncoa6^HMS00664, Scer\GAL4^GMR.PU

(Qing et al., 2014)

Scer\GAL4^GMR.PU, yki^UAS.cHa has eye phenotype, suppressible by trr^HMS01019/Scer\GAL4^GMR.PU

(Qing et al., 2014)

Scer\GAL4^Tub.PU, yki^UAS.cHa has wing disc | somatic clone phenotype, suppressible by Myc⁴

(Neto-Silva et al., 2010)

Scer\GAL4^Tub.PU, yki^UAS.cHa has eye disc | somatic clone phenotype, suppressible by sd¹²/sd¹²

(Wu et al., 2008)

Scer\GAL4^GMR.PF, yki^UAS.cHa has eye phenotype, suppressible by sd[+]/sd¹²

(Wu et al., 2008)

yki^UAS.cHa has interommatidial bristle | increased number phenotype, suppressible by Df(3L)mir-ban^Δ1

(Nolo et al., 2006)

yki^UAS.cHa has pigment cell | increased number phenotype, suppressible by Df(3L)mir-ban^Δ1

(Nolo et al., 2006)

Scer\GAL4^Tub.PU, yki^UAS.cHa has wing disc | somatic clone phenotype, suppressible by Df(3L)mir-ban^Δ1

(Thompson and Cohen, 2006)

NOT suppressed by

Statement

Reference

Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa has wing disc | proximal | somatic clone phenotype, non-suppressible by hth^UAS.GFP/Scer\GAL4^Tub.PU

(Khan et al., 2013)

Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa has wing disc | distal | somatic clone phenotype, non-suppressible by Scer\GAL4^Tub.PU/hth^HMS01112

(Khan et al., 2013)

yki^UAS.cHa has eye disc | somatic clone phenotype, non-suppressible by Tgi^ΔP

(Koontz et al., 2013)

Scer\GAL4^αTub84B.PL, yki^UAS.cHa has eye | somatic clone | pupal stage phenotype, non-suppressible by Df(1)jub^I, Scer\GAL4^αTub84B.PL

(Das Thakur et al., 2010)

Scer\GAL4^GMR.PF, yki^UAS.cHa has eye phenotype, non-suppressible by kibra^EP747/Scer\GAL4^GMR.PF

(Genevet et al., 2010)

Enhancer of

Statement

Reference

yki^UAS.cHa/Scer\GAL4^ap-md544 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Scer\GAL4^ap-md544, pnut^GD1512

(Gerlach et al., 2018)

yki^UAS.cHa/Scer\GAL4^ey.PH is an enhancer of ommatidium | adult stage | somatic clone phenotype of Scer\GAL4^ey.PH, dachs^GC13, ft^G-rv

(Brittle et al., 2012)

Suppressor of

Statement

Reference

yki^UAS.cHa/Scer\GAL4^C587 is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, vg^UAS.cKa

(Li et al., 2015)

yki^UAS.cHa/Scer\GAL4^C587 is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}

(Li et al., 2015)

yki^UAS.cHa/Scer\GAL4^C587 is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa

(Li et al., 2015)

yki^UAS.cHa/Scer\GAL4^Tub.PU is a suppressor | partially of wing disc | proximal | somatic clone phenotype of Scer\GAL4^Tub.PU, l(2)gl⁴, vg^UAS.cKa

(Khan et al., 2013)

yki^UAS.cHa/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of hid^GMR.PG

(Schoenherr et al., 2012)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Verghese et al., 2012)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of eye disc phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Verghese et al., 2012)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of photoreceptor neuron phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Verghese et al., 2012)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of pigment cell phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Verghese et al., 2012)

yki^UAS.cHa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Verghese et al., 2012)

yki^UAS.cHa/Scer\GAL4^Tub.PU is a suppressor of eye photoreceptor cell | somatic clone | progressive phenotype of ft⁸

(Napoletano et al., 2011)

yki^UAS.cHa/Scer\GAL4^Tub.PU is a suppressor of wing pouch | somatic clone phenotype of vg^83b27-R

(Wu et al., 2008)

NOT Suppressor of

Statement

Reference

yki^UAS.cHa/Scer\GAL4^RapGAP1-OK6 is a non-suppressor of NMJ bouton | increased number phenotype of Scer\GAL4^RapGAP1-OK6, Strip^RNAi.UAS.9

(Sakuma et al., 2016)

yki^UAS.cHa/Scer\GAL4^Tub.PU is a non-suppressor of wing disc | distal | somatic clone phenotype of Scer\GAL4^Tub.PU, l(2)gl⁴, vg^UAS.cKa

(Khan et al., 2013)

yki^UAS.cHa, Scer\GAL4^T80, Dronc^CARD.UAS is a non-suppressor of wing disc | somatic clone phenotype of Myc⁴

(Neto-Silva et al., 2010)

Other

Statement

Reference

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has wing disc | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^ap-md544, pnut^GD1512, yki^UAS.cHa has wing disc dorsal compartment | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^hh.PU, pnut^GD1512, yki^UAS.cHa has wing disc | third instar larval stage phenotype

(Gerlach et al., 2018)

Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa has wing disc | distal | somatic clone phenotype

(Khan et al., 2013)

Scer\GAL4^Tub.PU, l(2)gl⁴, yki^UAS.cHa has wing disc | proximal | somatic clone phenotype

(Khan et al., 2013)

Scer\GAL4^GMR.PF, sd^UAS.cSa, yki^UAS.cHa has eye phenotype

(Wu et al., 2008)

Mmus\Tead2^UAS.cWa, Scer\GAL4^GMR.PF, yki^UAS.cHa has eye phenotype

(Wu et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of yki^UAS.cHa and pnut^GD1512 from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] enhances the third instar larval wing disc dorsal compartment enlargement induced by the expression of yki^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts], even leading to the formation of tumors and to cell polarity defects (i.e. mislocalization of Discs large protein); this tumor phenotype is enhanced by the co-expression of bsk^DN.UAS. The pnut^GD1512, yki^UAS.cHa co-expressing larvae fail to pupate and, instead, continue to grow to form giant larvae.

The co-expression of yki^UAS.cHa and pnut^GD1512 under the control of either Scer\GAL4^hh.PU or Scer\GAL4^e22c leads to a much more severe enlargement of the wing disc posterior compartment as compared to the yki^UAS.cHa single expression condition; the Scer\GAL4^hh.PU-driven co-expression also leads to some of the expressing cells moving and invading the wing disc anterior compartment.

The third instar larval wing disc dorsal compartment enlargement induced by the expression of yki^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] is significantly enhanced by the co-expression of dia^HMS00308, chb^HMS01146, pbl^JF02979 or Incenp^GD7511.

The co-expression of yki^UAS.cHa enhances the polyploidy/aneuploidy in the third instar larval wing disc dorsal compartment induced by the expression of pnut^GD1512 from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts].

(Gerlach et al., 2018)

Co-expression of cact^HMS00084 suppresses the reduced survival rates in response to Staphylococcus aureus (and the increase in bacterial load) seen in male flies with overexpression of yki^Scer\UAS.cHa driven in the fat body by Scer\GAL4^r4.

(Liu et al., 2016)

The increased number of satellite boutons on neuromuscular junctions in third instar larvae expressing Strip^{dsRNA.shRNA.Scer\UAS.9} under the control of Scer\GAL4^RapGAP1-OK6 is not suppressed by co-expression of yki^Scer\UAS.cHa.

(Sakuma et al., 2016)

The tumorous germaria phenotype induced by Scer\GAL4^C587-driven expression of vg^Scer\UAS.cKa is partially rescued by co-expression of yki^Scer\UAS.cHa.

The rather moderate tumorous germarium phenotype characteristic for adult female flies expressing ci^{dsRNA.shRNA.Scer\UAS.P\T} under the control of Scer\GAL4^C587 is significantly improved by co-expression of yki^Scer\UAS.cHa. Co-expression of yki^Scer\UAS.cHa can also partially rescue the aggravated tumorous phenotype of flies expressing both ci^{dsRNA.shRNA.Scer\UAS.P\T} and hpo^Scer\UAS.cWa simultaneously.

(Li et al., 2015)

Co-expression of tai^HMS00673, nos^JF02931, or piwi^HMS00606 partially suppresses the wing disc posterior compartment overgrowth of larvae expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^en.PU.

nos^L7/Df(3R)Exel6183 partially suppresses the wing disc posterior compartment overgrowth of larvae expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^en.PU.

(Zhang et al., 2015)

Smurf^15C dominantly enhances the enlarged eyes caused by overexpressing Scer\GAL4^tub.PU>yki^Scer\UAS.cHa.

(Cao et al., 2014)

Expression of Ncoa6^HMS00664 suppresses the increase in eye size seen when yki^Scer\UAS.cHa is expressed under the control of Scer\GAL4^GMR.PU.

Expression of trr^HMS01019 suppresses the increase in eye size seen when yki^Scer\UAS.cHa is expressed under the control of Scer\GAL4^GMR.PU.

(Qing et al., 2014)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU in l(2)gl⁴ mutant wing disc mutant clones results in overproliferation and neoplastic transformation in both the proximal and distal domains, although the onset of neoplasia is delayed in distal cells compared to proximal cells.

Expression of yki^Scer\UAS.cHa does not suppress the poor recovery rate of distal wing clones expressing vg^Scer\UAS.cKa under the control of Scer\GAL4^tub.PU in a l(2)gl⁴ mutant background. Extensive cell death is still seen. Survival of proximal clones is somewhat improved, but unlike in l(2)gl⁴ mutant clones alone, neoplastic transformation is still not observed until day four of clone induction and the clones display dense cell packing and compact nuclear morphology.

Expression of hth^HMS01112 does not suppress the overproliferation and neoplastic transformation seen in both the proximal and distal wing disc domains when yki^Scer\UAS.cHa is expressed under the control of Scer\GAL4^tub.PU in l(2)gl⁴ mutant clones.

(Khan et al., 2013)

Tgi^ΔP has no effect on the tissue overgrowth seen in eye disc clones expressing yki^Scer\UAS.cHa.

(Koontz et al., 2013)

Co-expression of Ack^Scer\UAS.cSb and yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PU results in a massively overgrown eye.

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PU suppresses the reduced eye size caused by W^GMR.PG and also results in a reduction in pigmentation.

(Schoenherr et al., 2012)

Co-expression of Nc^pro.Scer\UAS with yki^Scer\UAS.cHa in the developing eye (under the control of Scer\GAL4^GMR.PF), causes a significant reduction in the adult eye size, compared to expression of yki^Scer\UAS.cHa alone.

Co-expression of Nc^pro.Scer\UAS in yki^Scer\UAS.cHa-expressing cells (both under the control of Scer\GAL4^GMR.PF) results in a decrease in cell division and an increase in apoptosis, compared to expression of yki^Scer\UAS.cHa alone.

(Verghese et al., 2012)

Expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU within ft⁸ clones suppresses the retinal degeneration normally seen in them.

(Napoletano et al., 2011)

Overexpression of yki^Scer\UAS.cHa in Ras85D^V12.Scer\UAS MARCM clones generates larger tumorigenic overgrowths than in either single mutant clone.

Overexpression of yki^Scer\UAS.cHa in dlg1^GD4689 MARCM clones generates larger tumorigenic overgrowths than in either single mutant clone.

Co-expression of yki^Scer\UAS.cHa with os^Scer\UAS.cZa in third instar eye imaginal disc MARCM clones results in a large tumorigenic overgrowth phenotype.

(Willecke et al., 2011)

Animals co-expressing both kibra^Scer\UAS.cBa and yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF show the same eye overgrowth phenotype as animals expressing yki^Scer\UAS.cHa alone under the control of Scer\GAL4^GMR.PF.

(Baumgartner et al., 2010)

Homozygous mutant clones of Df(1)djub^I also overexpressing yki^Scer\UAS.cHa driven by Scer\GAL4^αTub84B.PL display phenotypes identical to overexpression of yki^Scer\UAS.cHa alone.

(Das Thakur et al., 2010)

Expression of yki^Scer\UAS.cHa (using the MARCM system under the control of Scer\GAL4^tub.PU) suppresses the growth defects seen in Df(1)btd-Sp1 leg disc clones generated in second instar larvae. yki^Scer\UAS.cHa expression is also able to rescue the defects seen in Df(1)btd-Sp1 adult leg clones.

(Estella and Mann, 2010)

dm⁴ mutant wing discs expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU display very small double-mutant clones.

Expression of yki^Scer\UAS.cHa and Nc^{CARD.Scer\UAS} under the control of Scer\GAL4^T80 in dm⁴ mutant wing disc clones does not rescue clone size.

(Neto-Silva et al., 2010)

Co-expression of kibra^{Scer\UAS.P\T.cYa} and yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in an eye size similar to that caused by expression of yki^Scer\UAS.cHa alone under the control of Scer\GAL4^GMR.PF.

(Yu et al., 2010)

Mosaic clones expressing sd^Scer\UAS.cSa and yki^Scer\UAS.cHa under the control of Scer\GAL4^αTub84B.PP overgrow relative to yki^Scer\UAS.cHa clones.

Mosaic clones expressing sd^GD4744 and yki^Scer\UAS.cHa under the control of Scer\GAL4^αTub84B.PP, while larger than wild-type clones, do not exhibit the same level of hyperplasia as yki^Scer\UAS.cHa clones.

Mosaic clones expressing dm^GD1419 and yki^Scer\UAS.cHa (both under the control of Scer\GAL4^αTub84B.PP) display a significantly reduced number of cells compared to wild-type clones (and compared to dm^GD1419 clones). The number of cells decreases even further when these clones are induced earlier in development.

In a competitive background (engineered through the presence of dm^αTub84B.PBb that is removed in the mutant clones), yki^Scer\UAS.cHa clones (under the control of Scer\GAL4^αTub84B.PP) show a diminished ability to overgrow compared to a wild-type background. Besides the reduction in size, yki^Scer\UAS.cHa clones show an important reduction in clone number both in discs and adult wings. Moreover yki^Scer\UAS.cHa clones induced earlier in development are never recovered at the end of larval development.

In dm^PL35/+;dm^αTub84B.PBb females, yki^Scer\UAS.cHa overexpression clones are smaller than wild-type, whereas in males they are completely outcompeted by 48 hours after heat-shock.

Mosaic clones expressing hth^GD4741 and yki^Scer\UAS.cHa (under the control of Scer\GAL4^αTub84B.PP) exhibit down-regulation of dm in the notum and do not grow tumors in that region. These clones are indistinguishable from yki^Scer\UAS.cHa clones in the wing pouch region (where hth expression is not detected).

(Ziosi et al., 2010)

Co-expression of sd^Scer\UAS.cSa and yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in eyes which are severely overgrown (and much larger than the eyes of animals expressing yki^Scer\UAS.cHa alone under the control of Scer\GAL4^GMR.PF) and folded. There is a general loss of eye pigmentation in the posterior region of the eye.

The large eye phenotype caused by expression of yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF is suppressed by sd¹²/+.

The large size and round shape of clones in the eye disc expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU is suppressed if the clones are also homozygous for sd¹².

Homozygous vg^83b27-R clones that are also expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU are readily recovered in the wing blade region of the wing disc.

(Wu et al., 2008)

In clones with a Df(3L)ban^Δ1 background, the induction of extra interommatidial cells causes by expression of yki^Scer\UAS.cHa, under the control of Scer\GAL4^GMR.PF in a wild-type background, is partially suppressed. The Scer\GAL4^GMR.PF>yki^Scer\UAS.cHa, Df(3L)ban^Δ1 retinae have 3.1 cells in regions corresponding to one side of an ommatidial hexagon between two vertices while the number if 5.9 cells in Scer\GAL4^GMR.PF>yki^Scer\UAS.cHa retinae but 1.67 cells in wild-type retinae.

(Nolo et al., 2006)

Df(3L)ban^Δ1 mutant clones in the wing that overexpress yki^Scer\UAS.cHa under the control of Scer\GAL4^tub do not grow to be as large as those that overexpress yki^Scer\UAS.cHa in wild-type clones.

(Thompson and Cohen, 2006)

Xenogenetic Interactions

Statement

Reference

Co-expression of Mmus\Tead2^Scer\UAS.cWa and yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in eyes which are severely overgrown (and much larger than the eyes of animals expressing yki^Scer\UAS.cHa alone under the control of Scer\GAL4^GMR.PF) and folded. There is a general loss of eye pigmentation in the posterior region of the eye.

(Wu et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

600526

w^*; P{UAS-yki}3/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

yki^Scer\UAS.cHa

yki^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Huang

Secondary FlyBase IDs

References (66)

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