FlyBase Allele Report: Dmel\Pink1[UAS.Tag:HA]

General Information

Symbol

Dmel\Pink1^UAS.Tag:HA

Species

D. melanogaster

Name

FlyBase ID

FBal0193147

Feature type

allele

Associated gene

Dmel\Pink1

Associated Insertion(s)

Carried in Construct

P{UAS-Pink1.HA}

Also Known As

UAS-PINK1, UAS-HA-PINK1

Key Links

Transgenic product class

wild_type

(Park et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Park et al., 2006)

Mutagen

in vitro construct

(Park et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Pink1.HA}

Cytology

Description

UAS regulatory sequences drive expression of Pink1 tagged with Tag:HA.

(Park et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Pink1

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease 6

CEA

(Min et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by trp^P365

(Huang et al., 2016)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

DOES NOT ameliorate Huntington's disease

modeled by park¹, Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

modeled by Marf^RNAi.cUa.UAS, Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

modeled by porin^k05123, Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

model of Parkinson's disease 6

is exacerbated by Tg^A.UAS

(Min et al., 2015)

is ameliorated by Tg^NIG.7356R

(Min et al., 2015)

ameliorates late onset Parkinson's disease

modeled by Hsap\ZNF746^DM.UAS

(Pirooznia et al., 2020)

ameliorates autosomal dominant distal hereditary motor neuronopathy 2

modeled by Hsap\HSPB8^{K141T.UAS.cKa}

(Kang et al., 2023)

modeled by Hsap\HSPB8^{K141E.UAS.cKa}

(Kang et al., 2023)

ameliorates autosomal dominant distal hereditary motor neuronopathy 4

modeled by Hsap\HSPB3^Y118H.UAS

(Han et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Co-expression (but not single expression of either construct) of park^{Scer\UAS.T:Zzzz\FLAG} and Pink1^{Scer\UAS.T:Ivir\HA1} ameliorates neurodegenerative disease modeled by trp^P365.

(Huang et al., 2016)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PI

(Pirooznia et al., 2020)

lethal, with Scer\GAL4^Mef2.PR

(Poole et al., 2008)

viable, with Scer\GAL4^elav.PU

(Khalil et al., 2015)

visible, with Scer\GAL4^ey.PH

(Poole et al., 2008)

visible, with Scer\GAL4^ey.PU

(Koh et al., 2012)

visible, with Scer\GAL4^GMR.PF

(Poole et al., 2008)

visible, with Scer\GAL4^GMR.PU

(Min et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PF

(Song et al., 2013, Whitworth et al., 2008)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Poole et al., 2008)

eye, with Scer\GAL4^ey.PU

(Koh et al., 2012)

eye, with Scer\GAL4^GMR.PF

(Song et al., 2013, Poole et al., 2008)

eye, with Scer\GAL4^GMR.PU

(Min et al., 2015)

eye | adult stage, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

ommatidium, with Scer\GAL4^ey.PU

(Koh et al., 2012)

ommatidium | adult stage, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Detailed Description

Statement

Reference

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} has no impact on ommatidia even at one month of age.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} using Scer\GAL4^elav.PU has no impact on the longevity of flies.

(Khalil et al., 2015)

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PU results in a rough eye phenotype (disrupted ommatidial array organisation and bristle loss).

(Min et al., 2015)

Flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU do not exhibit any discernible eye phenotype, as compared to controls.

(Hwang et al., 2014)

Flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF exhibit a rough eye phenotype and disarrayed ommatidia.

(Song et al., 2013)

Flies with overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^ey.PU have small eyes with disrupted ommatidial patterns.

(Koh et al., 2012)

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF or Scer\GAL4^ey.PH results in a rough eye phenotype.

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Mef2.PR results in complete lethality.

(Poole et al., 2008)

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF causes a disorganisation of the ommatidial array and roughening of the external eye morphology.

(Whitworth et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Tg^A.UAS, Scer\GAL4^GMR.PU

(Min et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH has visible phenotype, enhanceable by Lon^GD14030, Scer\GAL4^ey.PH

(Thomas et al., 2014)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by +/Df(1)Exel6239

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Opa1[+]/Opa1^s3475

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Marf^GD11094, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by park^UAS.cGa, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by park^UAS.cGa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by HtrA2^UAS.cPa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Suppressed by

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU has viable phenotype, suppressible by park^UAS.Tag:MYC, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Tg^NIG.7356R, Scer\GAL4^GMR.PU

(Min et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^Mef2.PR has visible phenotype, suppressible by Lon[+]/Lon^G3998

(Thomas et al., 2014)

Pink1^UAS.Tag:HA, Scer\GAL4^Mef2.PR has visible phenotype, suppressible by Df(3L)Exel9011/+

(Thomas et al., 2014)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PU has visible phenotype, suppressible | partially by Sirt1^KK109370, Scer\GAL4^ey.PU

(Koh et al., 2012)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PU has visible phenotype, suppressible | partially by Sirt1^GD11580, Scer\GAL4^ey.PU

(Koh et al., 2012)

Pink1^UAS.Tag:HA, Scer\GAL4^Mef2.PR has lethal phenotype, suppressible | partially by park²⁵/park²⁵

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, suppressible by park²⁵/park²⁵

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH has visible phenotype, suppressible by park²⁵/park²⁵

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Df(2L)C144/+

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Drp1[+]/Drp1^T26

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Drp1^GD10456, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible | partially by park²⁵

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park²⁵ has visible | adult stage phenotype, suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible | partially by HtrA2^Δ1

(Whitworth et al., 2008)

NOT suppressed by

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park^UAS.cGa has visible | adult stage phenotype, non-suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by rho-7^pΔ1

(Whitworth et al., 2008)

Enhancer of

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Scer\GAL4^GMR.PU, Tg^A.UAS

(Min et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, rho-7^UAS.cWa

(Whitworth et al., 2008)

Suppressor of

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HSPB3^Y118H.UAS, Scer\GAL4^elav.PU

(Han et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HSPB8^{K141E.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of decreased rate of adult walking behavior | progressive phenotype of Hsap\HSPB8^{K141E.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HSPB8^{K141T.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of decreased rate of adult walking behavior | progressive phenotype of Hsap\HSPB8^{K141T.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

park^UAS.Tag:FLAG, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy | dominant | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a suppressor | partially of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

NOT Suppressor of

Statement

Reference

Pink1^UAS.Tag:HA/Scer\GAL4^GMR.PF is a non-suppressor of abnormal neuroanatomy | dominant | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+]

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+]

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Marf^RNAi.cUa.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, porin[+]/porin^k05123

(Khalil et al., 2015)

Scer\GAL4^unspecified/Pink1^UAS.Tag:HA is a non-suppressor of abnormal flight phenotype of park²⁵

(Poole et al., 2008)

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB is a non-suppressor of visible phenotype of park¹

(Park et al., 2006)

Other

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park^UAS.Tag:MYC has lethal phenotype

(Song et al., 2013)

Pink1^UAS.Tag:HA, Scer\GAL4^hs.PB, park^UAS.Tag:MYC has lethal | pupal stage | heat sensitive phenotype

(Park et al., 2009)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, rho-7^SA.UAS has visible phenotype

(Whitworth et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tg^A.UAS, Scer\GAL4^GMR.PU

(Min et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH has eye phenotype, enhanceable by Lon^GD14030, Scer\GAL4^ey.PH

(Thomas et al., 2014)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH has eye phenotype, enhanceable by Lon^HMS01060, Scer\GAL4^ey.PH

(Thomas et al., 2014)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by +/Df(1)Exel6239

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Opa1[+]/Opa1^s3475

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Marf^GD11094, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by park^UAS.cGa, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, enhanceable by park^UAS.cGa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, enhanceable by park^UAS.cGa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, enhanceable by HtrA2^UAS.cPa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Suppressed by

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Tg^NIG.7356R, Scer\GAL4^GMR.PU

(Min et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^Mef2.PR has thorax phenotype, suppressible by Df(3L)Exel9011/+

(Thomas et al., 2014)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Sirt1^KK109370, Scer\GAL4^ey.PU

(Koh et al., 2012)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PU has ommatidium phenotype, suppressible | partially by Sirt1^KK109370, Scer\GAL4^ey.PU

(Koh et al., 2012)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Sirt1^GD11580, Scer\GAL4^ey.PU

(Koh et al., 2012)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PU has ommatidium phenotype, suppressible | partially by Sirt1^GD11580, Scer\GAL4^ey.PU

(Koh et al., 2012)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, suppressible by park²⁵/park²⁵

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH has eye phenotype, suppressible by park²⁵/park²⁵

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(2L)C144/+

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Drp1[+]/Drp1^T26

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Drp1^GD10456, Scer\GAL4^GMR.PF

(Poole et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, suppressible | partially by park²⁵

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, suppressible | partially by park²⁵

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park²⁵ has eye | adult stage phenotype, suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park²⁵ has ommatidium | adult stage phenotype, suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, suppressible | partially by HtrA2^Δ1

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, suppressible | partially by HtrA2^Δ1

(Whitworth et al., 2008)

NOT suppressed by

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park^UAS.cGa has eye | adult stage phenotype, non-suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, park^UAS.cGa has ommatidium | adult stage phenotype, non-suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, non-suppressible by rho-7^pΔ1

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, non-suppressible by rho-7^pΔ1

(Whitworth et al., 2008)

Enhancer of

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Tg^A.UAS

(Min et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, rho-7^UAS.cWa

(Whitworth et al., 2008)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, rho-7^UAS.cWa

(Whitworth et al., 2008)

Suppressor of

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of larval ventral nerve cord phenotype of Hsap\HSPB8^{K141E.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of mitochondrion | larval stage phenotype of Hsap\HSPB8^{K141E.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of mitochondrion | larval stage phenotype of Hsap\HSPB8^{K141T.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

Pink1^UAS.Tag:HA, Scer\GAL4^elav-C155 is a suppressor of larval ventral nerve cord phenotype of Hsap\HSPB8^{K141T.UAS.cKa}, Scer\GAL4^elav-C155

(Kang et al., 2023)

park^UAS.Tag:FLAG, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF is a suppressor of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a suppressor | partially of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a suppressor | partially of mitochondrion phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a suppressor | partially of adult antennal lobe phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

NOT Suppressor of

Statement

Reference

Pink1^UAS.Tag:HA/Scer\GAL4^GMR.PF is a non-suppressor of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a non-suppressor of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU, park¹/park[+]

(Khalil et al., 2015)

Pink1^UAS.Tag:HA, Scer\GAL4^elav.PU is a non-suppressor of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Marf^RNAi.cUa.UAS, Scer\GAL4^elav.PU

(Khalil et al., 2015)

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB is a non-suppressor of wing phenotype of park¹

(Park et al., 2006)

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB is a non-suppressor of adult thorax phenotype of park¹

(Park et al., 2006)

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB is a non-suppressor of myofibril & skeletal muscle of thorax phenotype of park¹

(Park et al., 2006)

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB is a non-suppressor of mitochondrion & skeletal muscle of thorax phenotype of park¹

(Park et al., 2006)

Other

Statement

Reference

Pink1^UAS.Tag:HA, Scer\GAL4^hs.PB, park^UAS.Tag:MYC has mitochondrion & indirect flight muscle phenotype

(Park et al., 2009)

Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF, rho-7^SA.UAS has eye phenotype

(Whitworth et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} or park^{Scer\UAS.T:Zzzz\FLAG} driven by Scer\GAL4^GMR.PF does not suppress age-dependent retinal degeneration (loss of rhabdomeres from photoreceptors) in trp^P365/+ flies; co-expression of both Pink1^{Scer\UAS.T:Ivir\HA1} and park^{Scer\UAS.T:Zzzz\FLAG} results in significant partial suppression of the phenotype.

(Huang et al., 2016)

Co-expression of Pink1^{Scer\UAS.T:Ivir\HA1} and park^{Scer\UAS.T:Hsap\MYC} using Scer\GAL4^elav.PU is deleterious as no adult flies emerge from pupae.

(Khalil et al., 2015)

Co-expression of Tg^A.Scer\UAS and Pink1^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PU results in enhanced rough eye phenotypes compared to expression of either construct alone. Co-expression of Tg^NIG.7356R partially suppresses the rough eye phenotype seen in flies with Pink1^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PU.

(Min et al., 2015)

Expression of Lon^GD14030 enhances the disorganised eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ey.PH.

Expression of Lon^HMS01060 enhances the disorganised eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ey.PH.

Heterozygous Lon^G3998 suppresses the thoracic indentation phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^Mef2.PR.

Heterozygous Df(3L)Exel9011 suppresses the thoracic indentation phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^Mef2.PR.

(Thomas et al., 2014)

Co-expression of park^{Scer\UAS.T:Hsap\MYC} and Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in lethality.

(Song et al., 2013)

Co-expression of Sirt1^KK109370 or Sirt1^GD11580 partially suppresses eye phenotypes seen in Scer\GAL4^ey.PU>Pink1^{Scer\UAS.T:Ivir\HA1} flies.

(Koh et al., 2012)

Co-expression of Pink1^{Scer\UAS.T:Ivir\HA1} and park^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB at 25[o]C results in pupal lethality, but at 18[o]C, several adult escapers are obtained. These escapers have smaller mitochondria in the indirect flight muscles compared to controls.

(Park et al., 2009)

The rough eye phenotype of flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF or Scer\GAL4^ey.PH is suppressed in a park²⁵/park²⁵ background.

The lethality phenotype of flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Mef2.PR is partially rescued in a park²⁵/park²⁵ background.

The rough eye phenotype of flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is enhanced in the presence of Df(1)Exel6239/+ or Opa1^s3475/+ mutations, or by co-expression of park^Scer\UAS.cGa or Marf^GD11094.

The rough eye phenotype of flies expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed in the presence of Df(2L)C144/+ or Drp1^T26/+ mutations, or by co-expression of Drp1^GD10456.

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^unspecified does not rescue the flight defects of park²⁵/park²⁵ mutants.

(Poole et al., 2008)

park²⁵ partially suppresses the rough eye and ommatidial organisation phenotypes seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PF. Addition of HtrA2^Δ1 suppresses the phenotype completely.

Co-expression of Pink1^{Scer\UAS.T:Ivir\HA1} and park^Scer\UAS.cGa under the control of Scer\GAL4^GMR.PF results in a severe rough eye phenotype, which greatly exceeds that conferred when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed alone. This phenotype is not suppressed in a HtrA2^Δ1 mutant background.

Expression of HtrA2^Scer\UAS.cPa enhances the disorganised eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PF, resulting in a significant reduction in eye size. This phenotype is not suppressed in a park²⁵ mutant background.

HtrA2^Δ1 largely suppresses the rough eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PF.

rho-7^pΔ1 does not suppress the disorganised eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} enhances the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF. The eye is much smaller with distorted morphology and complete loss of bristles. A less severe rough eye phenotype is seen when Pink1^{Scer\UAS.T:Ivir\HA1} is co-expressed with rho-7^SA.Scer\UAS.

(Whitworth et al., 2008)

The defective wing and thorax phenotypes seen in park¹ mutant flies are not rescued by expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB. Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB also fails to rescue the enlarged mitochondria and apoptotic muscle cells seen in adult park¹ thoracic muscles.

(Park et al., 2006)

Xenogenetic Interactions

Statement

Reference

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} significantly reduces mitochondrial spheroid formation in photoreceptor neurons. Pseudo-pupil analysis reveal that Pink1^{Scer\UAS.T:Ivir\HA1} overexpression markedly reduces photoreceptor loss in 1-day-old flies.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} results in the reduction of the number of degenerative neurons showing cytoplasmic vacuolization in the olfactory lobes. Pink1^{Scer\UAS.T:Ivir\HA1} significantly increases both mean and median survival of flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in heterozygous park¹ flies which also express Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} fails to increase life span.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in heterozygous park¹ flies which also express Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} fails to provide protection against photoreceptor degeneration.

Co-expression of Marf^{miRNA.cUa.Scer\UAS} results in a significant reduction of Pink1^{Scer\UAS.T:Ivir\HA1}-mediated neuronal rescue in Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies.

Overexpression of Pink1^{Scer\UAS.T:Ivir\HA1} in the presence of heterozygous porin^k05123 fails to extend lifespan or suppress neuronal loss in flies also expressing Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Khalil et al., 2015)

Co-expression of Hsap\UCP2^Scer\UAS.cFa and Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU does not result in a rough eye phenotype.

(Hwang et al., 2014)

Complementation and Rescue Data

Rescues

Scer\GAL4^how-24B/Pink1^UAS.Tag:HA rescues Pink1^B9

(Zhu et al., 2015)

Scer\GAL4^elav.PU/Pink1^UAS.Tag:HA rescues Pink1^B9

(Tufi et al., 2014)

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB rescues Pink1^B9

(Song et al., 2013)

Pink1^UAS.Tag:HA rescues Pink1^B9

(Kim et al., 2008)

Partially rescues

Pink1^UAS.Tag:HA/Scer\GAL4^hs.PB partially rescues Pink1^B9

(Park et al., 2006)

Comments

The enlarged or aggregated mitochondria phenotype observed in the body wall muscles of Pink1^B9 hemizygous male third instar larvae is restored by expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^how-24B.

(Zhu et al., 2015)

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU rescues the loss of dopaminergic neurons in the PPL1 cluster and adult thorax defects of Pink1^B9 flies.

(Tufi et al., 2014)

Expressing Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB rescues the crushed thorax and downturned wing phenotypes seen in Pink1^B9 mutant flies at both 3 and 45 days post-eclosion. The mitochondrial defects, reduction in ATP levels and flightlessness are also rescued. Expression of Pink1^{Scer\UAS.T:Ivir\HA1} suppresses the dopaminergic neuron loss in 45 day old Pink1^B9 mutant flies.

(Song et al., 2013)

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB almost fully rescues the apparent behavioural phenotypes of Pink1^B9 mutants. Similarly, impaired mitochondria in the indirect flight muscle of Pink1^B9 mutants are fully recovered by Pink1^{Scer\UAS.T:Ivir\HA1} expression under the control of Scer\GAL4^hs.PB.

(Kim et al., 2008)

The reduced climbing ability, flightless and downturned wing phenotypes seen in Pink1^B9 flies are rescued by expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB. The collapsed thorax phenotype seen in Pink1^B9 flies is largely rescued by expression of Pink1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB.

(Park et al., 2006)

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Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pink1^{Scer\UAS.T:Ivir\HA1}

Pink1^UAS.Tag:HA

Name Synonyms

Secondary FlyBase IDs

References (23)

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