FB2024_03 , released June 25, 2024
Allele: Scer\GAL4DBD.elav
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General Information
Symbol
Scer\GAL4DBD.elav
Species
S. cerevisiae
Name
FlyBase ID
FBal0198072
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{elav-GAL4.DBD}
Also Known As
elav-Gal4DBD, elavGal4DBD
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Luan et al., 2006)
Progenitor genotype
Carried in construct
P{elav-GAL4.DBD}
Cytology
Description

An elav promoter regulates expression of a GAL4(DBD)::Zip- hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain). An internal ribosomal entry site (IRES) from the Ubx gene followed by DsRed(Unk) coding sequence is present downstream of the hemidriver sequence, but this is not expressed in the nervous system.

(Luan et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
elav
Encoded product / tool
GAL4(DBD)::Zip-
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      wandering third instar larval stage
      embryonic/larval central nervous system

      Comment: when combined with P{elav-GAL4.AD}

      when combined with P{elav-VP16.AD}

      (Luan et al., 2006)
      adult stage
      neuron

      Comment: when combined with P{1xCRE-p65.AD}

      when combined with P{3xCRE-p65.AD}

      when combined with P{6xCRE-p65.AD}

      when combined with P{9xCRE-p65.AD}

      (Siegenthaler et al., 2019)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      elav
      (Luan et al., 2006)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Of 10 Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL lines made, only the P{elav-GAL4.DBD}H9 line is viable when crossed to the Hsim\VP16AD.elav.T:Zzzz\ZipEERRL,T:SV40\nls2 hemidriver.

      (Luan et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The T:Disc\RFP tag is not expressed from this construct.

      (Luan et al., 2006)

      When Scer\GAL4AD.elav.T:Zzzz\ZipEERRL,T:SV40\nls2 and Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL are expressed together in the same cell, they function as a complete GAL4 driver. Hsim\VP16AD.elav.T:Zzzz\ZipEERRL,T:SV40\nls2 and Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL also function together as a GAL4 driver.

      (Luan et al., 2006)

      Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL and Scer\GAL4AD.Ccap.T:Zzzz\ZipEERRL,T:SV40\nls2 function together as a GAL4 driver and drive reporter expression within the more restricted Ccap pattern, although some expression is seen outside of this pattern in different neurons.

      (Luan et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Scer\GAL4DBD.elav.T:Zzzz\Zip-
      Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL
      Scer\GAL4DBD.elav
      elavDBD
      (Siegenthaler et al., 2019)
      elavGal4DBD
      (Luan et al., 2006, Luan et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (16)