FB2024_03 , released June 25, 2024
Allele: Dmel\Wnt4K2
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General Information
Symbol
Dmel\Wnt4K2
Species
D. melanogaster
Name
FlyBase ID
FBal0217408
Feature type
allele
Associated gene
Dmel\Wnt4
Associated Insertion(s)
P{lArB}Wnt4K2
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Lim et al., 2005)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lArB}Wnt4K2
    Cytology
    Description

    P{lArB} insertion 12bp upstream of the 5' untranslated region of Wnt4.

    (Lim et al., 2005)
    Allele components
    Component
    Use(s)
    Inserted element
    P{lArB}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Wnt4K2 mutants show 30-40% viability. Wnt4K2/Df(2L)spdj2 adult escapers have mild roughness and indentation in the equatorial region of the eye. This phenotype is temperature sensitive (penetrance is approximately 30% at 29oC and 5% at 23oC). These flies also have ectopic wing vein material between longitudinal veins 1 and 2.

        Adult Wnt4K2/Df(2L)spdj2 escapers raised at 29oC show reversals of dorsoventral planar polarity in the eye. Approximately 90% of these polarity reversals are found in the ventral side of the eye near the equator. Ommatidia with excess, fused or missing photoreceptor cells are also seen. At 23oC, Wnt4K2/Df(2L)spdj2 escapers have nearly normal ommatidial structure, except for a few ommatidia right at the equator. These eyes also show dorsoventral polarity reversals, again preferentially (90%) in the ventral region of the eye.

        Homozygous clones in the wing do not result in significant defects in wing hair polarity.

        (Lim et al., 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Wnt4K2/wgl-17 flies show no detectable eye defects.

        (Lim et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Precise excision of the P{lArB} insertion reverts the mutant phenotype.

        (Lim et al., 2005)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        DWnt4K2
        (Lim et al., 2005)
        Wnt4K2
        Name Synonyms
        Secondary FlyBase IDs
          References (1)