FlyBase Allele Report: Dmel\Drice[17]

General Information

Symbol

Dmel\Drice¹⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0219086

Feature type

allele

Associated gene

Dmel\Drice

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Xu et al., 2006)

Mutagen

ethyl methanesulfonate

(Xu et al., 2006)

Progenitor genotype

Cytology

Description

Amino acid replacement: N116Y.

(Xu et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:29,800,243..29,800,243 [+]

Nucleotide change:

A29800243T

Amino acid change:

N116Y | Drice-PA

Reported amino acid change:

N116Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Xu et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult optic lobe | P-stage

(Akagawa et al., 2015)

dendrite (with Drice^Δ1), with Scer\GAL4^ppk.PG

(Schoenmann et al., 2010)

eye disc

(Xu et al., 2006)

eye disc | somatic clone

(Xu et al., 2006)

interommatidial precursor cell | pupal stage | increased number

(Xu et al., 2006)

midline glial cell

(Xu et al., 2006)

neuron (with Drice^Δ1), with Scer\GAL4^ppk.PG

(Schoenmann et al., 2010)

peptidergic neuron | adult stage | ectopic

(Lee et al., 2013)

peptidergic neuron | adult stage | ectopic (with Drice^Δ1)

(Lee et al., 2013)

wing

(Xu et al., 2006)

Detailed Description

Statement

Reference

In Drice¹⁷ mutants, the number of apoptotic cells in the optic lobe is greatly increased at 24h APF, and remains increased compared to wild type through late pupal stages. Cell corpse clearance is greatly reduced in several regions of the optic lobe, but is normal in other regions.

(Akagawa et al., 2015)

The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is suppressed in Ice¹⁷ mutant homozygotes. On average 10 bursCCAP cells are seen per tissue at 3-5 days.

The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is strongly suppressed in Ice^Δ1/Ice¹⁷ mutants; six bursCCAP neurons survive in 3-5 day old flies.

(Lee et al., 2013)

Ice¹⁷/Ice^Δ1 trans-heterozygous mutants exhibit a reduction in dendritic branch pruning at 18 hours after puparium formation.

(Schoenmann et al., 2010)

Only approximately one-third of the expected number of homozygotes are recovered. The lethal phase occurs during embryogenesis without a detectable phenotype.

Homozygous flies have wings that appear less transparent compared to wild type.

Cell death is significantly reduced compared to wild type in homozygous embryos lacking both zygotic and maternal Ice function. Stage 17 mutant embryos have contain on average more than twice the number of midline glia cells compared to wild-type controls.

Apoptosis in the eye disc at 26 hours after puparium formation (APF) is reduced in mutants compared to wild type. At 42 hours APF the homozygous clones in the eye disc contain on average 1.6 +/- 0.75 additional interommatidial cells compared to wild-type controls. In rare cases, a bristle cell is replaced by a tertiary pigment cell.

Fewer apoptotic cells are induced after irradiation in mutant embryos compared to wild type.

(Xu et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Drice¹⁷ has decreased cell death | embryonic stage phenotype, enhanceable by Dcp-1^Prev1

(Xu et al., 2006)

Suppressor of

Statement

Reference

Drice^Δ1/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^L1/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^L2/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^C1/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^C2/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^S1/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^S2/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^Δ1/Drice¹⁷ is a suppressor of visible phenotype of rpr^GMR.PW

(Wu et al., 2016)

Df(3R)Drice/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Xu et al., 2006)

Drice¹⁷/Drice¹⁷ is a suppressor of visible phenotype of rpr^GMR.PW

(Xu et al., 2006)

NOT Suppressor of

Statement

Reference

Drice[+]/Drice¹⁷ is a non-suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice[+]/Drice¹⁷ is a non-suppressor of visible phenotype of rpr^GMR.PW

(Wu et al., 2016)

Drice¹⁷/Drice¹⁷ is a non-suppressor of increased cell death | third instar larval stage phenotype of Dronc^pro.UAS, Scer\GAL4^GMR.PU

(Xu et al., 2006)

Drice¹⁷/Drice¹⁷ is a non-suppressor of increased cell death | third instar larval stage phenotype of Dronc^ΔN.UAS, Scer\GAL4^GMR.PU

(Xu et al., 2006)

Drice¹⁷/Drice¹⁷ is a non-suppressor of visible phenotype of Dcp-1^ΔN.GMR

(Xu et al., 2006)

Other

Statement

Reference

Dcp-1^Prev1, Drice¹⁷ has abnormal cell death | P-stage phenotype

(Akagawa et al., 2015)

Dcp-1^Prev1, Drice¹⁷ has abnormal cell death | germline clone phenotype

(Baum et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

Drice^Δ1/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^L1/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^L2/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^C1/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^C2/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^S1/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^S2/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^Δ1/Drice¹⁷ is a suppressor of eye phenotype of rpr^GMR.PW

(Wu et al., 2016)

Df(3R)Drice/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Xu et al., 2006)

Drice¹⁷/Drice¹⁷ is a suppressor of eye phenotype of rpr^GMR.PW

(Xu et al., 2006)

NOT Suppressor of

Statement

Reference

Drice[+]/Drice¹⁷ is a non-suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice[+]/Drice¹⁷ is a non-suppressor of eye phenotype of rpr^GMR.PW

(Wu et al., 2016)

Drice¹⁷/Drice¹⁷ is a non-suppressor of eye disc | third instar larval stage phenotype of Dronc^pro.UAS, Scer\GAL4^GMR.PU

(Xu et al., 2006)

Drice¹⁷/Drice¹⁷ is a non-suppressor of eye disc | third instar larval stage phenotype of Dronc^ΔN.UAS, Scer\GAL4^GMR.PU

(Xu et al., 2006)

Drice¹⁷/Drice¹⁷ is a non-suppressor of eye phenotype of Dcp-1^ΔN.GMR

(Xu et al., 2006)

Other

Statement

Reference

Dcp-1^Prev1, Drice¹⁷ has adult optic lobe | P-stage phenotype

(Akagawa et al., 2015)

Dcp-1^Prev1, Drice¹⁷ has egg chamber | germline clone phenotype

(Baum et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Drice¹⁷/Drice¹⁷, Drice¹⁷/Drice^Δ1, Drice¹⁷/Drice^L1, Drice¹⁷/Drice^L2, Drice¹⁷/Drice^C1, Drice¹⁷/Drice^C2, Drice¹⁷/Drice^S1, Drice¹⁷/Drice^S2 (but not Drice¹⁷/+) significantly suppresses the eye ablation phenotype in hid^GMR.PG flies. Drice¹⁷/Drice^Δ1 (but not Drice^Δ1/+) significantly suppresses the eye ablation phenotype in rpr^GMR.PW flies. Drice¹⁷/+ does not suppress the eye ablation phenotype in rpr^GMR.PW flies.

(Wu et al., 2016)

In Drice¹⁷ and Dcp-1^Prev1 double mutants, the number of apoptotic cells is reduced compared to wild type between 0-24h APF, and is slightly increased between 48-72h APF.

(Akagawa et al., 2015)

Homozygous Ice¹⁷ clones induced in the eye suppress the eye ablation phenotype caused by W^GMR.PG.

The eye ablation phenotype caused by W^GMR.PG is suppressed if the flies are also carrying Ice¹⁷/Ice¹⁷ or Ice¹⁷/Df(3R)Ice.

The eye ablation phenotype caused by rpr^GMR.PW is weakly suppressed by homozygosity for Ice¹⁷.

Ice¹⁷ Dcp-1^Prev1 double mutant embryos derived from mutant female germline clones (so lacking maternal and zygotic function of Ice and Dcp-1 show significantly reduced levels of apoptosis compared to Ice¹⁷ single maternal and zygotic mutant embryos, containing only a few dying cells.

Homozygosity for Ice¹⁷ does not suppress the apoptosis induced in the third larval instar eye disc by expression of either Nc^pro.Scer\UAS or Nc^ΔN.Scer\UAS under the control of Scer\GAL4^GMR.PU.

The "spotted" eye phenotype caused by Dcp-1^ΔN.GMR is not suppressed by homozygosity for Ice¹⁷.

(Xu et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Drice¹⁷ is rescued by Drice^fl.GMR

(Xu et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

DrICE¹⁷

(McSharry and Beitel, 2019)

Drice¹⁷

(Kietz et al., 2022, Reiff et al., 2019, Chen et al., 2016, Rudrapatna et al., 2013)

Ice¹⁷

drICE¹⁷

(Wu et al., 2016, Akagawa et al., 2015, Mendes et al., 2006, Xu et al., 2006)

drice¹⁷

(Lee et al., 2013, Marchal et al., 2012, Schoenmann et al., 2010, Baum et al., 2007)

su(GMR-hid)17

(Xu et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

Open Close