FB2024_03 , released June 25, 2024
Allele: Dmel\CG33228D2
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General Information
Symbol
Dmel\CG33228D2
Species
D. melanogaster
Name
FlyBase ID
FBal0239019
Feature type
allele
Associated gene
Dmel\CG33228
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(3R)D2
    Cytology
    Description

    Deletion with one breakpoint in CG33228 and the other breakpoint in the Pof promoter region.

    (Johansson et al., 2007)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        The lethality of the Df(3R)D2 deletion chromosome (which affects both Pof and CG33228 transcription units) is caused by an effect on CG33228 (represented by the CG33228D2 allele) and not by an effect on Pof; transheterozygotes of CG33228D2 with either CG33228CB-6312-3 or CG33228SH0542 (two alleles caused by insertions within the CG33228 open reading frame) are lethal, whereas newly generated excision alleles that only affect the Pof transcription unit and not the CG33228 transcription unit are viable.

        (Johansson et al., 2007)

        FlyBase curator comment: the lethality of the Df(3R)D2 deletion chromosome has been shown (see FBrf0202200) to be due to an effect on CG33228 (represented by the CG33228D2 allele) and not due to an effect on Pof as originally reported in FBrf0179298.

        (Larsson et al., 2004)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        CG33228D2
        Name Synonyms
        Secondary FlyBase IDs
          References (2)