FlyBase Allele Report: Dmel\RhoGEF2[UAS.cUa]

General Information

Symbol

Dmel\RhoGEF2^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0241120

Feature type

allele

Associated gene

Dmel\RhoGEF2

Associated Insertion(s)

Carried in Construct

P{UAS-RhoGEF2.U}

Also Known As

UAS-RhoGEF2

Key Links

Transgenic product class

wild_type

(Yan et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yan et al., 2009)

Mutagen

in vitro construct

(Yan et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-RhoGEF2.U}

Cytology

Description

UAS regulatory sequences drive expression of RhoGEF2.

(Yan et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

RhoGEF2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | conditional | third instar larval stage, with Scer\GAL4^ap-md544, Scer\GAL80^ts.αTub84B

(Widmann and Dahmann, 2009)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR44E04

(Marmor-Kollet et al., 2019)

abnormal size | adult stage, with Scer\GAL4^GMR44E04

(Marmor-Kollet et al., 2019)

Phenotype Manifest In

adult mushroom body beta-lobe, with Scer\GAL4^GMR44E04

(Marmor-Kollet et al., 2019)

alpha/beta Kenyon cell | adult stage, with Scer\GAL4^GMR44E04

(Marmor-Kollet et al., 2019)

wing disc | conditional | third instar larval stage, with Scer\GAL4^ap-md544, Scer\GAL80^ts.αTub84B

(Widmann and Dahmann, 2009)

Detailed Description

Statement

Reference

Expressing RhoGEF2^UAS.cUa under the control of Scer\GAL4^GMR44E04 leads to adult mushroom body β-axons over-extending beyond the midline in about half of cases.

(Marmor-Kollet et al., 2019)

Expression of RhoGEF2^Scer\UAS.cUa in the dorsal compartment of the wing disc (under the temperature-regulated control of Scer\GAL4^ap-md544 by Scer\GAL80^ts.αTub84B) results in shorter cells compared with control cells.

(Widmann and Dahmann, 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^GMR44E04/RhoGEF2^UAS.cUa is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of plum^Δ1

(Marmor-Kollet et al., 2019)

Scer\GAL4^GMR44E04/RhoGEF2^UAS.cUa is a suppressor | partially of abnormal size | adult stage phenotype of plum^Δ1