FB2024_03 , released June 25, 2024
Allele: Dmel\ver1
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General Information
Symbol
Dmel\ver1
Species
D. melanogaster
Name
FlyBase ID
FBal0246413
Feature type
allele
Associated gene
Dmel\ver
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Raffa et al., 2010)
Mutagen
ethyl methanesulfonate
(Raffa et al., 2010)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T?C.

(Raffa et al., 2010)

The natural stop codon at codon 215 is converted into a glutamine codon. This is predicted to produce a protein containing 12 additional amino acids compared to the wild-type protein.

(Raffa et al., 2010)

Amino acid replacement: term215Q.

(Raffa et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:12,525,083..12,525,083 [+]
Nucleotide change:

T12525083C

Amino acid change:

term215Q | ver-PA; term215Q | ver-PB

Reported amino acid change:

term215Q

Comment:

Stop codon mutated, predicted to result in a polypeptide that is 12 residues longer than wild-type. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Position of mutation on reference sequence inferred by FlyBase curator.

(Raffa et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In ver1 homozygous larvae, neuroblasts exhibit telomeric fusions, particularly in autosomes.

      (Cenci et al., 2015)

      Mutants trans-heterozygous for ver342 and ver1 survive as fertile adults.

      (Zhang et al., 2014)

      Homozygotes die at the larval/pupal boundary.

      The mitotic cells from the brains of homozygous, ver1/verS147910 and ver1/Df(3L)sex204 larvae show frequent telomeric associations, some of which generate multicentric chromosomes that resemble little "trains" of chromosomes. Both single telomeric associations (a single telomere associated with either its sister or a nonsister telomere) and double telomeric associations (a pair of sister telomeres associated with another pair) are seen.

      (Raffa et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      verS147910

      (Raffa et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ver1
      (Porrazzo et al., 2022, Cicconi et al., 2017, Cenci et al., 2015, Zhang et al., 2014, Raffa et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)