FlyBase Allele Report: Dmel\Rabex-5[ex42]

General Information

Symbol

Dmel\Rabex-5^ex42

Species

D. melanogaster

Name

FlyBase ID

FBal0246624

Feature type

allele

Associated gene

Dmel\Rabex-5

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Deletion allele.

(Yan et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage (with Df(3L)BSC250)

(Thomas and Strutt, 2014)

lethal | larval stage (with Df(3L)BSC250)

(Yan et al., 2010)

lethal | larval stage | recessive

(Yan et al., 2010)

lethal | P-stage (with Df(3L)BSC250)

(Yan et al., 2010)

lethal | P-stage | recessive

(Yan et al., 2010)

melanotic mass phenotype | larval stage (with Df(3L)BSC250)

(Thomas and Strutt, 2014, Yan et al., 2010)

melanotic mass phenotype | larval stage | recessive

(Yan et al., 2010)

melanotic mass phenotype | P-stage (with Df(3L)BSC250)

(Yan et al., 2010)

melanotic mass phenotype | P-stage | recessive

(Yan et al., 2010)

neoplasia | larval stage (with Df(3L)BSC250)

(Thomas and Strutt, 2014)

visible, with Rabex-5^VDRC.cUa, Scer\GAL4^C-765

(Yan et al., 2010)

Phenotype Manifest In

eye-antennal disc | larval stage (with Df(3L)BSC250)

(Thomas and Strutt, 2014)

imaginal disc | larval stage (with Df(3L)BSC250)

(Thomas and Strutt, 2014)

melanotic mass | larval stage (with Df(3L)BSC250)

(Thomas and Strutt, 2014)

posterior crossvein, with Rabex-5^VDRC.cUa, Scer\GAL4^C-765

(Yan et al., 2010)

wing vein

(Yan et al., 2010)

wing vein L2, with Rabex-5^VDRC.cUa, Scer\GAL4^C-765

(Yan et al., 2010)

Detailed Description

Statement

Reference

Rabex-5^ex42/Df(3L)BSC250 larvae grow excessively due to delayed pupation and have occasional melanotic tumours. Imaginal discs have an overgrown and folded epithelium and increased cell size. The eye-antennal discs are often fused with the brain lobes

(Thomas and Strutt, 2014)

Rabex-5^ex42 homozygotes or heterozygotes over Df(3L)BSC250 die as giant larvae or giant pupae, often containing melanotic tumors.

Rabex-5^ex42/+ enhances the wing phenotype resulting from Rabex-5^VDRC.cUa expression driven by Scer\GAL4^C-765.

Homozygous Rabex-5^ex42 mutant wings display extra veins.

(Yan et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Rabex-5^ex42/Df(3L)BSC250 has neoplasia | larval stage phenotype, suppressible | partially by Stat92E^F

(Thomas and Strutt, 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Rabex-5^ex42/Df(3L)BSC250 has eye-antennal disc | larval stage phenotype, suppressible | partially by Stat92E^F

(Thomas and Strutt, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Stat92E^F significantly suppresses the tumourous phenotype of Rabex-5^ex42 imaginal discs: eye-antennal discs are no longer fused to the brain, and show a relatively wild-type shape and structure, although abnormal folds are still seen.

(Thomas and Strutt, 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rabex-5^ex42

(Thomas and Strutt, 2014, Yan et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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