FB2024_03 , released June 25, 2024
Allele: Scer\GAL4GMR12E03
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General Information
Symbol
Scer\GAL4GMR12E03
Species
S. cerevisiae
Name
FlyBase ID
FBal0249755
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR12E03-GAL4}
Also Known As
R12E03, 12E03
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR12E03-GAL4}
Cytology
Description

A 2567 base pair fragment from the flanking non-coding or intronic region of Gycbeta100B is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR12E03
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      gamma Kenyon cell
      (Bouzaiane et al., 2015)
      adult brain | restricted
      (Bouzaiane et al., 2015)
      proboscis muscle 2 ventral motor neuron
      (McKellar et al., 2020)
      neuron | subset of adult central nervous system
      (McKellar et al., 2020)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using shi1.UAS at 33[o]C) of Scer\GAL4GMR12E03 cells in adults significantly reduces short term (5 min) aversive olfactory memory, but not its anaesthesia-resistant component, compared to controls; inhibition during testing significantly reduces medium term (3 h) aversive olfactory memory, including its anaesthesia-resistant component, compared to controls, with no effect on long term (24 h after massed training) memory; inhibition does not affect olfactory acuity, compared to controls.

      Inhibition (using shi1.UAS at 33[o]C) of a subset of Scer\GAL4GMR12E03 cells in adults (restricted using Scer\GAL80Mef2.mb247) does not affect short term (5 min) aversive olfactory memory; inhibition during testing does not affect medium term (3 h) aversive olfactory memory, or its anaesthesia-resistant component, compared to controls.

      (Bouzaiane et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR12E03
      Name Synonyms
      Secondary FlyBase IDs
        References (6)