FB2024_03 , released June 25, 2024
Allele: Scer\GAL4GMR22B11
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General Information
Symbol
Scer\GAL4GMR22B11
Species
S. cerevisiae
Name
FlyBase ID
FBal0250633
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR22B11-GAL4}
Also Known As
R22B11
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR22B11-GAL4}
Cytology
Description

A 2745 base pair fragment from the flanking non-coding or intronic region of AlstR is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR22B11
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      antennal mechanosensory and motor center B1 projection neuron
      (Vaughan et al., 2014)
      adult antennal lobe projection neuron | subset
      (Vaughan et al., 2014)
      medulla | restricted
      (Vaughan et al., 2014)
      adult glial cell | subset
      (Vaughan et al., 2014)
      thoracic neuromere | restricted
      (Vaughan et al., 2014)
      adult dorsal metathoracic nerve | restricted
      (Vaughan et al., 2014)
      adult stage | male
      antennal mechanosensory and motor center B1 projection neuron
      (Zhou et al., 2015)
      Additional Information
      Statement
      Reference

      A FLP/FRT intersectional strategy shows expression of ScerGAL4GMR22B11 in antennal mechanosensory and motor center B1 projection neuron when combined with EcollexAfru.P1.

      (Zhou et al., 2015)

      ScerGAL4GMR22B11 drives expression mainly in antennal mechanosensory and motor center B1 projection neuron, but also drives expression in adult antennal lobe projection neurons, medullary neurons, glia and approximately 12 neurons in the thoracic neuromeres with minor innervation of the haltere nerve.

      (Vaughan et al., 2014)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Ctet\TeTxLCFRT.stop.UAS with Scer\FLP1L.8xlexAop) of neurons expressing Ecol\lexAfru.P1 and Scer\GAL4GMR22B11 significantly reduces male-male courtship chaining responses to pulse song, compared to controls.

      Optogenetic activation (using Cnoc\ChR1Cs.20xUAS.FRT.Venus with Scer\FLP1L.8xlexAop and activating with 655 nm (red) light) of neurons expressing Ecol\lexAfru.P1 and Scer\GAL4GMR22B11 does not affect male-male courtship chaining, compared to controls.

      (Zhou et al., 2015)

      Inhibition (using shi1.UAS at 30[o]C) of Scer\GAL4GMR22B11 neurons in adult females significantly reduces receptivity to mating, compared to controls; in males, courtship pulse song-induced locomotion is not significantly affected, compared to controls.

      (Vaughan et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR22B11
      Name Synonyms
      Secondary FlyBase IDs
        References (5)