GCC to GAA/G mutation. Analogous mutation in human VCP implicated in inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.
eye, with Scer\GAL4GMR.PF
Expression of TER94A229E.Scer\UAS under the control of Scer\GAL4Hand.PU does not cause any obvious morphological defects in the adult heart although the diastolic diameter and fractional shortening is reduced in both 1 and 5 weeks old flies compared to age-matched controls. Expression under the Scer\GAL4how-24B disrupts both the cardioblasts organization and the intersegmental somatic muscle pattern and leads to abnormal twisting of the dorsal vessel in stage 16 embryos.
Expression of TER94A229E.Scer\UAS under the control of Scer\GAL4C57 disrupts lysosomal tubular network in third instar larval muscles.
Flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4hs.PU exhibit increased ATPase activity and a reduction in cellular ATP level compared to controls.
Embryos overexpressing TER94A229E.Scer\UAS driven by Scer\GAL4how-24B display disorganised muscle fibers.
Flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4Mhc.PW show impaired flight.
Myofibrils from flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4Mhc.PW show disrupted sarcomeres without repetitive A-bands.
Flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4Mhc.PW and Scer\GAL80ts.αTub84B are able to fly normally at the permissive temperature, while they loose their ability to fly when shifted to the restrictive temperature.
Expression of TER94A229E.Scer\UAS under the control of Scer\GAL4elav-C155 results in a mushroom body midline-crossing phenotype in mutant brains.
Flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4elav-C155 exhibit olfactory learning deficits.
Rhabdomeres are disorganised in the retinas of flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4GMR.PF.
Eyes of flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4GMR.PF display noticeable roughness.
Retinas from flies expressing TER94A229E.Scer\UAS under the control of Scer\GAL4ninaE.PT show a cell-autonomous progressive degeneration of outer R cells and rhabdomere disorganisation. Dietary restriction does not mitigate the photoreceptor cell phenotype, although constant darkness does.
Heterozygosity for TER94k15502 ameliorates the rough eye and photoreceptor cell phenotypes resulting from the overexpression of TER94A229E.Scer\UAS under the control of Scer\GAL4GMR.PF.
Co-expression of TER94Scer\UAS.cCa and TER94A229E.Scer\UAS under the control of Scer\GAL4GMR.PF results in rough eye and photoreceptor cell abnormalities.
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, enhanceable by sip3GD3145/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, enhanceable by Der-1GD818, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, suppressible by Der-1UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, suppressible by Der-1UAS.Tag:FLAG, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, suppressible by Der-1UAS.Tag:MYC.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, suppressible by Der-1Δα.UAS, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, suppressible by Der-1L204G.UAS, Scer\GAL4GMR.PF
Scer\GAL4ninaE.PT, TER94A229E.UAS has abnormal neuroanatomy phenotype, suppressible by PTPMT1GD4965, Scer\GAL4ninaE.PT
Scer\GAL4ninaE.PT, TER94A229E.UAS has abnormal neuroanatomy phenotype, suppressible by PTPMT1KK108325, Scer\GAL4ninaE.PT
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, non-suppressible by Ufd1UAS.cLa/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, non-suppressible by sip3UAS.cLa/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, non-suppressible by Der-1ΔSHP.UAS, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, non-suppressible by Der-2UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has visible phenotype, non-suppressible by Der-1CT.UAS.GFP, Scer\GAL4GMR.PF
TER94A229E.UAS, Scer\GAL4GMR.PF is a suppressor of visible phenotype of Der-1UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS, Ufd1KK108134 has lethal phenotype
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, enhanceable by sip3GD3145/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, enhanceable by sip3GD3145/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, enhanceable by Der-1GD818, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, enhanceable by Der-1GD818, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, suppressible by Der-1UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, suppressible by Der-1UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, suppressible by Der-1UAS.Tag:FLAG, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, suppressible by Der-1UAS.Tag:FLAG, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, suppressible by Der-1UAS.Tag:MYC.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, suppressible by Der-1UAS.Tag:MYC.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, suppressible by Der-1Δα.UAS, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, suppressible by Der-1Δα.UAS, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, suppressible by Der-1L204G.UAS, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, suppressible by Der-1L204G.UAS, Scer\GAL4GMR.PF
Scer\GAL4ninaE.PT, TER94A229E.UAS has outer photoreceptor cell phenotype, suppressible by PTPMT1GD4965, Scer\GAL4ninaE.PT
Scer\GAL4ninaE.PT, TER94A229E.UAS has outer photoreceptor cell phenotype, suppressible by PTPMT1KK108325, Scer\GAL4ninaE.PT
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, non-suppressible by Der-1ΔSHP.UAS, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, non-suppressible by Der-2UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, non-suppressible by Der-2UAS.cLa, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, non-suppressible by Der-1CT.UAS.GFP, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, non-suppressible by Der-1CT.UAS.GFP, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, non-suppressible by Ufd1UAS.cLa/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, non-suppressible by Ufd1UAS.cLa/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, non-suppressible by sip3UAS.cLa/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has photoreceptor phenotype, non-suppressible by sip3UAS.cLa/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, TER94A229E.UAS has eye phenotype, non-suppressible by Der-1ΔSHP.UAS, Scer\GAL4GMR.PF
TER94A229E.UAS, Scer\GAL4GMR.PF is a suppressor of eye phenotype of Der-1UAS.cLa, Scer\GAL4GMR.PF
Co-expression of Ufd1-likeKK108134 with TER94A229E.Scer\UAS under the control of Scer\GAL4GMR.PF results in lethality.
Expression of sip3GD3145 enhances the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1GD818 enhances the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Ufd1-likeScer\UAS.cLa has no apparent effect on the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of sip3Scer\UAS.cLa has no apparent effect on the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1Scer\UAS.cLa completely suppresses the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1Scer\UAS.cLa restores the reduction in cellular ATP level seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4hs.PU. The increase in ATPase activity is also rescued.
Expression of Der-1ΔSHP.Scer\UAS fails to suppress the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-2Scer\UAS.cLa fails to suppress the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1CT.Scer\UAS.T:Avic\GFP fails to suppress the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1Scer\UAS.T:Zzzz\FLAG suppresses the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1Scer\UAS.T:Hsap\MYC.cLa suppresses the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1Δα.Scer\UAS suppresses the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of Der-1L204G.Scer\UAS suppresses the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.
Expression of TER94A229E.Scer\UAS completely suppresses the severe eye defects seen when Der-1Scer\UAS.cLa is expressed under the control of Scer\GAL4GMR.PF.
Co-expression of PlipGD4965 under the control of Scer\GAL4ninaE.PT significantly suppresses the TER94A229E.Scer\UAS photoreceptor cell phenotype.
Co-expression of PlipKK108325 under the control of Scer\GAL4ninaE.PT significantly suppresses the TER94A229E.Scer\UAS photoreceptor cell phenotype.