FB2024_03 , released June 25, 2024
Allele: Scer\GAL45-HT1A.ERGP
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General Information
Symbol
Scer\GAL45-HT1A.ERGP
Species
S. cerevisiae
Name
FlyBase ID
FBal0277068
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{5-HT1A-GAL4.L}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Luo et al., 2012)
Progenitor genotype
Carried in construct
P{5-HT1A-GAL4.L}
Cytology
Description

A 5' enhancer region of 5-HT1A corresponding to 5kb of genomic DNA immediately upstream of the ATG start codon is fused to GAL4 coding sequences in an 'Enhancer Ready Gal4-P element' vector.

(Luo et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
5-HT1A
5-HT1A_5-HT1A-Gal4
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      larval ventral nerve cord
      (Luo et al., 2012)
      adult stage
      adult insulin secreting cell of pars intercerebralis
      (Luo et al., 2012)
      ellipsoid body
      (Luo et al., 2012)
      pars intercerebralis
      (Luo et al., 2012)
      immunolocalization
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      late third instar larval stage
      larval insulin secreting cell of pars intercerebralis
      (Luo et al., 2012)
      Additional Information
      Statement
      Reference

      In larvae, expression only begins in the late (wandering, non-feeding) third instar stage, despite how anti-Ilp2 staining is visible in insulin secreting cells of early third instar larvae. In larvae and adults, expression often colocalizes with serotonin-immunoreactive neuron processes.

      (Luo et al., 2012)
       
      Marker for
      Reflects expression of
      5-HT1A
      (Luo et al., 2012)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ablation (using hidUAS.cUa and rprUAS.cUa) of Scer\GAL45-HT1A.ERGP cells does not affect appetitive (fructose) or aversive (salt) olfactory memory or naive preference for olfactory or gustatory stimuli in larvae, compared to controls.

      (Huser et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL45-HT1A.ERGP
      Name Synonyms
      Secondary FlyBase IDs
        References (4)