FB2024_03 , released June 25, 2024
Allele: Dmel\CAP42b
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General Information
Symbol
Dmel\CAP42b
Species
D. melanogaster
Name
FlyBase ID
FBal0282653
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 2673bp deletion (coordinates 2R:6190378..6193141 , release 5 genome) that removes the first two SH3 domain-coding exons.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

2764 kb deletion resulting from the imprecise excision of P{PTT-GA}CAPCA06924.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous and hemizygous larvae do not show a significant hunching response to vibration, in contrast to wild-type controls.

Actin organisation at the muscle attachment site between lateral-ventral somatic muscles 6 and 7 in abdominal segments is severely disrupted in mutant larvae, resulting in a jagged boundary. There is a significantly enlarged gap between actin filaments from adjacent muscles at most muscle attachment sites. Integrin distribution is broader than normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)