FlyBase Allele Report: Dmel\Bace[2045]

General Information

Symbol

Dmel\Bace²⁰⁴⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0283018

Feature type

allele

Associated gene

Dmel\Bace

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: R21G.

(Bolkan et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Bace⁵²⁴³)

(Bolkan et al., 2012)

abnormal neuroanatomy | adult stage (with Df(2L)Exel7038)

(Bolkan et al., 2012)

fertile (with Df(2L)N22-14)

(Bolkan et al., 2012)

viable (with Df(2L)N22-14)

(Bolkan et al., 2012)

Phenotype Manifest In

adult brain (with Bace⁵²⁴³)

(Bolkan et al., 2012)

adult brain (with Df(2L)Exel7038)

(Bolkan et al., 2012)

adult lamina epithelial glial cell (with Df(2L)Exel7038)

(Bolkan et al., 2012)

adult subretinal glial cell (with Df(2L)Exel7038)

(Bolkan et al., 2012)

cell body rind of adult lamina (with Bace⁵²⁴³)

(Bolkan et al., 2012)

cell body rind of adult lamina (with Df(2L)Exel7038)

(Bolkan et al., 2012)

lamina (with Bace⁵²⁴³)

(Bolkan et al., 2012)

lamina (with Df(2L)Exel7038)

(Bolkan et al., 2012)

Detailed Description

Statement

Reference

28 day old Bace²⁰⁴⁵/Bace⁵²⁴³ and Bace²⁰⁴⁵/Df(2L)Exel7038 flies show degeneration of the lamina, with vacuolisation in the lamina cortex. The flies also show vacuoles in the lamina neuropil and central brain. 3 week old Bace²⁰⁴⁵/Bace⁵²⁴³ flies show gaps in the rows of glia in the subretinal layer and most of the epithelial glia are lost.

(Bolkan et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Bace²⁰⁴⁵/Df(2L)Exel7038 is rescued by Scer\GAL4^elav.PU/Bace^UAS.cCSa

(Bolkan et al., 2012)

Bace²⁰⁴⁵/Df(2L)Exel7038 is rescued by Scer\GAL4^Bace.5.4/Bace^UAS.cCSa

(Bolkan et al., 2012)

Comments

Expression of Bace^{Scer\UAS.cCSa} under the control of Scer\GAL4^elav.PU significantly reduces the vacuolisation of the lamina neuropil and cortex which is seen in 28 day old Bace²⁰⁴⁵/Df(2L)Exel7038 flies.

Expression of Bace^{Scer\UAS.cCSa} under the control of Scer\GAL4^Bace.5.4 completely rescues the vacuolisation of the lamina neuropil and cortex which is seen in 28 day old Bace²⁰⁴⁵/Df(2L)Exel7038 flies.

(Bolkan et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bace²⁰⁴⁵

dBACE²⁰⁴⁵

(Bolkan et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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