FB2024_03 , released June 25, 2024
Allele: Dmel\Sxlf18,f32
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General Information
Symbol
Dmel\Sxlf18,f32
Species
D. melanogaster
Name
FlyBase ID
FBal0294060
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Evans and Cline, 2013)
Progenitor genotype
Sxlf18
(Evans and Cline, 2013)
Cytology
Description

A double mutant allele derived from Sxlf18. A G-to-T transversion at +13,355 (relative to the Sxl[[Pm]] transcription start site) results in Gly-Val amino acid substitution three residues C-terminal to the second RNA-binding domain, a region common to all Sxl-F isoforms.

(Evans and Cline, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:7,084,715..7,084,715 [-]
Nucleotide change:

G7084715T

Amino acid change:

G253V | Sxl-PA; G261V | Sxl-PAB; G270V | Sxl-PAC; G283V | Sxl-PC; G293V | Sxl-PD; G253V | Sxl-PE; G285V | Sxl-PG; G285V | Sxl-PH; G285V | Sxl-PJ; G293V | Sxl-PL; G283V | Sxl-PN; G283V | Sxl-PO; G293V | Sxl-PP; G283V | Sxl-PR; G293V | Sxl-PT; G285V | Sxl-PW; G285V | Sxl-PX; G293V | Sxl-PY

Reported amino acid change:

G?V

Comment:

This is the site of the Sxlf32 transversion that substitutes a Val for a Gly three residues down from the conserved second RNA-binding domain. Sxlf18 is suppressed in cis by Sxlf32.

(Evans and Cline, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sxlf18,f32 is a dominant intragenic suppressor of recessive Sxlfs3 female sterility. Sxlf18,f32/Sxlfs3 females are fully viable and fertile.

      (Evans and Cline, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      Sxlf18

      (Evans and Cline, 2013)
      Comments

      Sxlf18,f32 is a dominant intragenic suppressor of recessive Sxlfs3 female sterility. Sxlf18,f32/Sxlfs3 females are fully viable and fertile.

      (Evans and Cline, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sxlf18,f32
      (Evans and Cline, 2013)
      Sxlf32
      (Evans and Cline, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)