FlyBase Allele Report: Dmel\udd[1]

General Information

Symbol

Dmel\udd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0294170

Feature type

allele

Associated gene

Dmel\udd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Zhang et al., 2014)

Progenitor genotype

PBac{WH}PAN2^f00130

(Zhang et al., 2014)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | germline clone | progressive

(Zhang et al., 2014)

decreased cell number | germline clone | progressive (with udd^null)

(Zhang et al., 2014)

decreased occurrence of cell division | germline clone | progressive

(Zhang et al., 2014)

decreased occurrence of cell division | germline clone | progressive (with udd^null)

(Zhang et al., 2014)

decreased size | adult stage

(Fefelova et al., 2022)

decreased size | adult stage (with udd^null)

(Fefelova et al., 2022)

sterile

(Fefelova et al., 2022)

sterile (with udd^null)

(Fefelova et al., 2022)

sterile | recessive

(Zhang et al., 2014)

viable

(Fefelova et al., 2022)

viable (with udd^null)

(Fefelova et al., 2022)

Phenotype Manifest In

egg chamber

(Fefelova et al., 2022)

egg chamber (with udd^null)

(Fefelova et al., 2022)

female germline stem cell | germline clone (with udd^null)

(Zhang et al., 2014)

female germline stem cell | germline clone | progressive

(Zhang et al., 2014)

ovary

(Fefelova et al., 2022)

ovary (with udd^null)

(Fefelova et al., 2022)

testis

(Fefelova et al., 2022)

testis (with udd^null)

(Fefelova et al., 2022)

Detailed Description

Statement

Reference

udd¹/udd¹ and udd¹/udd^null ovaries contain egg chambers only up to stages 4-5 of oogenesis.

(Fefelova et al., 2022)

Over time udd¹ mutant germline stem cell clones induced in female flies become less proliferative and are eventually lost from the cap cell niche.

Over time udd^null/udd¹ mutant germline stem cell clones induced in female flies become less proliferative and are eventually lost from the cap cell niche.

(Zhang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

udd¹ is a suppressor of female germline cell phenotype of bam^Δ86

(Zhang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

udd¹ partially suppresses the differentiation defects seen in bam^Δ86 mutant female germline cells. Many four- and eight-cell cysts with branched fusomes and ring canals are seen, but mature 16 cell cysts are not observed.

(Zhang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: PBac{WH}CG8232^f00130

(Zhang et al., 2014)

The udd¹ allele was isolated as a background mutation from the Exelixis stock PBac{WH}CG8232^f00130. Excision of the piggyBac transposon did not revert the recessive sterile phenotype.

(Zhang et al., 2014)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

udd¹

(Fefelova et al., 2022, Jang et al., 2021, Zhang et al., 2014)

Name Synonyms

under-developed1

(Zhang et al., 2014)

Secondary FlyBase IDs

References (3)

Report Sections

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