FB2024_03 , released June 25, 2024
Allele: Dmel\CG11699pogo108
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General Information
Symbol
Dmel\CG11699pogo108
Species
D. melanogaster
Name
FlyBase ID
FBal0298025
Feature type
allele
Associated gene
Dmel\CG11699
Associated Insertion(s)
pogo{}Kmn1pogo108
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    pogo{}Kmn1pogo108
    Cytology
    Description

    The insertion is located 7bp downstream of the distal polyadenylation signal and 12bp upstream of the distal cleavage site of CG11699. This disrupts the distal GU-rich downstream sequence element, such that the distal cleavage site is not used, and the mutant flies only produce CG11699 transcripts with a short 110bp 3'UTR (wild-type flies have two transcripts - some with a 110bp 3'UTR and some with a 221bp 3'UTR).

    (Mateo et al., 2014)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        CG11699pogo108 flies show increased survival on exposure to high levels of benzaldehyde compared to wild-type controls.

        CG11699pogo108 flies show increased resistance to the insecticide carbofuran compared to controls.

        Mutant flies do not show increased resistance to oxidative stress caused by hydrogen peroxide.

        (Mateo et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        CG11699pogo108
        Name Synonyms
        Secondary FlyBase IDs
          References (1)