FB2024_03 , released June 25, 2024
Allele: Dmel\Klp98AΔ47
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General Information
Symbol
Dmel\Klp98AΔ47
Species
D. melanogaster
Name
FlyBase ID
FBal0318789
Feature type
allele
Associated gene
Dmel\Klp98A
Associated Insertion(s)
TI{TI}Klp98AΔ47
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Derivery et al., 2015)
Mutagen
ends-out gene targeting
(Derivery et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}Klp98AΔ47
Cytology
Description

Deletion of the entire Klp98A coding region. An attP site and a single loxP site are present in place of the deleted sequence.

(Derivery et al., 2015)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:27,548,734..27,558,372 [-]
Comment:

Inferred boundaries of Klp98A coding region deletion created by homologous recombination. The coding sequence was replaced with the w[hs] gene flanked by two loxP sites followed by an AttP site.

(Derivery et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In Klp98AΔ47/Klp98AΔ8 mutants, Sara endosomes move diffusively and central spindle targeting fails during sensory organ precursor division; endosomes are symmetrically dispatched between pIIa and pIIb in Klp98AΔ47/Klp98AΔ6 or Klp98AΔ47/Klp98AΔ8 mutants.

      (Derivery et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Klp98AΔ47/+;Scer\GAL4pnr-MD237>neurKK107306 double mutants have a notum that is largely void of bristles; this phenotype is further enhanced in Klp98AΔ47/Klp98AΔ8;Scer\GAL4pnr-MD237>neurKK107306 double mutants.

      Klp98AΔ47/+;numb2/numbSW or Klp98AΔ47/+;numbSW/numb15 or Klp98AΔ47/+;Scer\GAL4pnr-MD237>numbdsRNA.Scer\UAS.T:Hsap\MYC mutants have a multiple socket phenotype on the notum; this phenotype is suppressed in Klp98AΔ47/Klp98AΔ6;numb2/numbSW, Klp98AΔ47/Klp98AΔ8;numb2/numbSW, Klp98AΔ47/Klp98AΔ6;numb15/numbSW, Klp98AΔ47/Klp98AΔ8;Scer\GAL4pnr-MD237>numbdsRNA.Scer\UAS.T:Hsap\MYC or Klp98AΔ47/Klp98AΔ6;Scer\GAL4pnr-MD237>numbdsRNA.Scer\UAS.T:Hsap\MYC double mutants.

      (Derivery et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Klp98AΔ47
      (Derivery et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)