FB2024_03 , released June 25, 2024
Allele: Scer\GAL4Ir60c.PC
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General Information
Symbol
Scer\GAL4Ir60c.PC
Species
S. cerevisiae
Name
Ionotropic receptor 60c promoter construct of Croset
FlyBase ID
FBal0325551
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{Ir60c-GAL4.C}
Also Known As
Ir60c-Gal4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Croset et al., 2016)
Progenitor genotype
Carried in construct
P{Ir60c-GAL4.C}
Cytology
Description

560bp of Ir56c genomic DNA drives expression of GAL4.

(Sánchez-Alcañiz et al., 2018)

The putative Ir60c regulatory region (covering the entire 5' intergenic region) regulates expression of a GAL4 driver.

(Croset et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Ir60c
Ir60c_SA36
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4Ir60c.PC cells in larvae does not affect attraction to appetitive concentrations of amino acids, compared to controls; inhibition abolishes the significant avoidance of high concentrations of alanine, compared to controls.

      Activation (using Mmmm\TRPV1E600K.UAS in the presence of capsaicin) of Scer\GAL4Ir60c.PC cells in larvae significantly reduces food intake, compared to controls.

      Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4Ir60c.PC cells does not affect base food intake, but significantly increases food intake in the presence of high concentrations of arginine or alanine, but not lysine or glycine, compared to controls.

      (Croset et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4Ir60c.PC
      Name Synonyms
      Ionotropic receptor 60c promoter construct of Croset
      Secondary FlyBase IDs
        References (4)