FB2024_03 , released June 25, 2024
Allele: Dmel\HΔM2.w+
Open Close
General Information
Symbol
Dmel\HΔM2.w+
Species
D. melanogaster
Name
FlyBase ID
FBal0326743
Feature type
allele
Associated gene
Dmel\H
Associated Insertion(s)
TI{TI}HΔM2.w+
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Smylla et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{TI}HΔM2.w+
Cytology
Description

A cDNA fragment containing mutated H sequence has been reintroduced into the attP site present in HattP, resulting in a H locus lacking introns and carrying a mutation in the second possible start codon (amino acid replacement M18V). A residual attR site is present in the 5'UTR and a loxP cassette containing a w[+] marker is present in the 3'UTR.

(Smylla et al., 2016)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult HΔM2.w+ homozygous mutants display bristle defects with, ~15 (out of 40 present in wild-type) of the large head and thorax bristles affected. Wing venation remains largely normal.

      (Smylla et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HΔM2.w+
      HΔM2[w+]
      (Smylla et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)