FB2024_03 , released June 25, 2024
Allele: Dmel\Lint-11
Open Close
General Information
Symbol
Dmel\Lint-11
Species
D. melanogaster
Name
FlyBase ID
FBal0343344
Feature type
allele
Associated gene
Dmel\Lint-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Coux et al., 2018)
Mutagen
CRISPR/Cas9
(Coux et al., 2018)
Progenitor genotype
Cytology
Description

Deletion of two cytosines (350 and 351) creates a premature stop codon at position 66/540.

(Coux et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:11,150,812..11,150,813 [+]
Comment:

The deletion of two C nucleotides leads to a frameshift and premature translation stop at codon 66 or 128 depending on the Lint-1 isoform.

(Coux et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 25[o]C temperature, Lint-11 homozygotes are viable and fertile, but egg chambers infrequently show misplaced or supernumerary oocytes. At 29[o]C, females are sterile, as eggs fail to hatch and a significant proportion of ovarioles develop aberrantly and contain egg chambers with extra number of germ cells or oocytes.

      (Coux et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Lint-11, l(3)mbt[+]/l(3)mbtGM76 has female sterile phenotype

      (Coux et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      At 25[o]C temperature, Lint-11/Lint-11, l(3)mbtGM76/+ females are sterile, unlike Lint-11/Lint-11 or l(3)mbtGM76/+ females.

      (Coux et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Lint-11
      (Coux et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)