FB2024_03 , released June 25, 2024
Allele: Dmel\αTub84BK40R.J
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General Information
Symbol
Dmel\αTub84BK40R.J
Species
D. melanogaster
Name
FlyBase ID
FBal0345034
Feature type
allele
Associated gene
Dmel\αTub84B
Associated Insertion(s)
TI{TI}αTub84BK40R.J
Carried in Construct
Also Known As
αTub84BK40R
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Jenkins et al., 2017)
Progenitor genotype
αTub84BKO-attP
(Jenkins et al., 2017)
Associated Insertion(s)
TI{TI}αTub84BK40R.J
Cytology
Description

αTub84B sequence which carries the K40R amino acid replacement has been knocked in to the attP site present in the αTub84BKO-attP knockout line.

(Jenkins et al., 2017)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:7,087,349..7,087,349 [+]
Nucleotide change:

A7087349G

Reported nucleotide change:

A?G

Amino acid change:

K40R | alphaTub84B-PA

Reported amino acid change:

K40R

Comment:

The endogenous AAG (lysine) codon was substituted with an AGG (arginine) codon.

(Wildonger, 2019.6.18)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Although the overall dendritic coverage in αTub84BK40R.J larval class IV da neurons appears normal, there is a progressive increase in the number of terminal branches (increase observed at 120h AEL, but not at 48h AEL), as compared to controls; dendrites show similar frequencies of both extension and retraction events, as compared to controls.

      (Jenkins et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      αTub84BK40R.J
      αTub84BK40R
      (Saunders et al., 2022, Jenkins et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)