Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
| General Information | |||
|---|---|---|---|
| Term | larval insulin secreting cell of pars intercerebralis | ID (Ontology) | FBbt:00110035 (Fly Anatomy) |
| Definition | Insulin-producing neurosecretory cell with its cell body in the larval pars intercerebralis (Ikeya et al., 2002). The same cells express Ilp2, Ilp3 and Ilp5 mRNA with different temporal profiles (Ikeya et al., 2002). An axonal branch projects to the contralateral side, looping posteriorly then anteriorly, and entering the nervus corporis cardiaci (Siegmund and Korge, 2001; Huckesfeld et al., 2021). This branch projects to the ring gland, where it has peptide release sites in the corpus cardiacum and along the aorta (Siegmund and Korge, 2001; Rulifson et al., 2002; Huckesfeld et al., 2021). Dendrites extend ventrally, close to the midline, reaching the subesophageal zone, and laterally, into the lateral protocerebrum (Siegmund and Korge, 2001; Rulifson et al., 2002; Huckesfeld et al., 2021). It receives synaptic input from hugin neurons of the protocerebrum (Schlegel et al., 2016). There are seven of these cells in each hemisphere (Cao and Brown, 2001; Rulifson et al., 2002; Ikeya et al., 2002; Park et al., 2008).[ FlyBase:FBrf0134726 FlyBase:FBrf0136823 FlyBase:FBrf0149175 FlyBase:FBrf0151837 FlyBase:FBrf0193772 FlyBase:FBrf0210278 FlyBase:FBrf0234450 FlyBase:FBrf0249161 ] | ||
| Also Known As | "larval corpus cardiacum and aorta innervating neurosecretory neuron of the pars intercerebralis 1" ; "larval corpus cardiacum innervating neuron CC/A-PI 1" ; "larval insulin producing cell of brain" (for all, see Synonyms field below) | ||
| Comment | Insulin-producing cells are found amongst the median neurosecretory cells, but not all mNSCs are IPCs (FBrf0212696), despite misleading phrasing in some articles (e.g. FBrf0184236). Synapsing identified in full L1 VNC EM volume - all insulin cells have connections from multiple hugin-PC cells (Schlegel et al., 2016). | ||
| Links to Extrernal Ontologies | |||
| VFB:FBbt_00110035 | |||
| Annotations | |||
| Records annotated with this term OR any of its CHILD TERMS | |||
|
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
|
|||
|
||||||
supraesophageal ganglion neuron |__larval neurosecretory cell of pars intercerebralis____ embryonic/larval neuron | |__embryonic/larval corpus cardiacum innervating neuron__| peptidergic neuron | |__insulin secreting cell of pars intercerebralis________| neurosecretory cell of pars intercerebralis | |__insulin secreting cell of pars intercerebralis________| |__larval neurosecretory cell of pars intercerebralis____| larval descending neuron | |__larval descending neuron to SEZ_______________________| efferent neuron | |__insulin secreting cell of pars intercerebralis________| larval efferent neuron | |__larval ring gland projection neuron___________________| neurosecretory cell of larval brain | |__larval neurosecretory cell of pars intercerebralis____| larval peptidergic neuron | |__larval ring gland projection neuron___________________| larval insulin secreting cell of pars intercerebralis 64 rec. |__larval Drosulfakinin neuron of pars intercerebralis 1 rec. |
| Spanning Tree View Settings | |||
|---|---|---|---|
| Parents/Children View Depth |
|||
Relationships
|
|||
| Is a |
insulin secreting cell of pars intercerebralis embryonic/larval corpus cardiacum innervating neuron larval neurosecretory cell of pars intercerebralis larval descending neuron to SEZ larval ring gland projection neuron |
||
| Part of | |||
|
Synonyms & Secondary IDs
|
|||
| Synonyms | |||
|
|||
| Secondary IDs | |||
|
|
|||
|
External Crossreferences & Linkouts
|
|||
| VFB:FBbt_00110035 | |||