Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | mushroom body output neuron 1 | ID (Ontology) | FBbt:00100234 (Fly Anatomy) |
| Definition | A bilateral, glutamatergic neuron whose cell body is located on the superior neuropils, anterior to the pars intercerebralis of the adult brain (Tanaka et al., 2008; Aso et al., 2014). The cell body fiber travels ventrally towards the medial lobe, arborizing in the anterior layer of beta' lobe slice 2 and the most medial segment of the gamma lobe (slice 5) (Tanaka et al., 2008). The main fiber then enters the opposite gamma lobe, arborizes in the beta' lobe slice 2 and gamma lobe slice 5. The major axon projects ipsilaterally to the superior medial protocerebrum (SMP), whereas a very thin axon projects to the crepine and SMP in the other hemisphere. There is one neuron of this type per hemisphere (Aso et al., 2014; Li et al., 2020). It develops from the larval MBON-k1 (Truman et al., 2023). These neurons have synaptic connections with protocerebral anterior medial (PAM) cluster neurons in the SMP and in the tip of the mushroom body horizontal lobe (Owald et al., 2015). It is involved in the retrieval of long term memory associated with water reward (Shyu et al., 2017) as well as medium and long term aversive memory (Bouzaiane et al., 2015).[ FlyBase:FBrf0205263 FlyBase:FBrf0227179 FlyBase:FBrf0228212 FlyBase:FBrf0228475 FlyBase:FBrf0235522 FlyBase:FBrf0248215 FlyBase:FBrf0255928 ] | ||
| Also Known As | "M6" ; "MB-M6" ; "MBON-01" (for all, see Synonyms field below) | ||
| Comment | Synapsing with PAM neurons determined by GRASP (Owald et al., 2015). | ||
| Links to Extrernal Ontologies | |||
| VFB:FBbt_00100234 | |||
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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interneuron |__primary interneuron________________________ adult neuron | |__adult SMPad3 lineage neuron________________| |__adult glutamatergic neuron_________________| primary neuron | |__primary interneuron________________________| adult mushroom body output neuron | |__adult typical mushroom body output neuron__| adult SMPad3 lineage clone | |__adult SMPad3 lineage neuron________________| CNS neuron | |__supraesophageal ganglion neuron____________| glutamatergic neuron | |__adult glutamatergic neuron_________________| DAMd1 lineage neuron | |__adult SMPad3 lineage neuron________________| mushroom body output neuron 1 41 rec. |
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| Is a |
supraesophageal ganglion neuron adult typical mushroom body output neuron adult SMPad3 lineage neuron primary interneuron adult glutamatergic neuron |
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| Develops from | larval mushroom body output neuron k1 | ||
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FlyBrain_NDB:10459 VFB:FBbt_00100234 |
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