FB2024_02 , released April 23, 2024
Gene Group: DEUBIQUITINASES
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General Information
Name
DEUBIQUITINASES
Species
D. melanogaster
Symbol
DUB
FlyBase ID
FBgg0000165
Date last reviewed
2014-02-24
Number of members
44
Description
Description
Deubiquitinases (DUBs) catalyze the proteolytic removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. Most are cysteine peptidases, though the JAMM domain-containing deubiquitinases are metallopeptidases. (Adapted from PMID:19626045 and PMID:19489724.)
Notes on Group
Source Material
The DEUBIQUITINASES Gene Group has been compiled using the following publication(s): Erven et al., 2022, Páhi et al., 2022, Badmos et al., 2021, Louis et al., 2015, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
deubiquitinase activity
Biological Process
protein deubiquitination
Cellular Component
Related Gene Groups
Parent group(s)
UBIQUITIN-LIKE PROTEIN PEPTIDASES
Component group(s)
CYSTEINE-TYPE DEUBIQUITINASES
JAMM DEUBIQUITINASES
SERINE-TYPE OTU DEUBIQUITINASES
Members (44)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
CYSTEINE-TYPE OTU DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG4968
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
CG7857
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Duba
Deubiquitinating enzyme A
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
trbd
trabid
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Yod1
Yod1 deubiquitinase
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
JAMM DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG2224
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
CG4751
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012)
eIF3f1
eukaryotic translation initiation factor 3 subunit f1
eIF3-S5
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
eIF3f2
eukaryotic translation initiation factor 3 subunit f2
eIF3f
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Zhang et al., 2012, Rawlings and Barrett, 1996-)
eIF3h
eukaryotic translation initiation factor 3 subunit h
eIF-3p40, l(2)k09003, Eukaryotic initiation factor 3 p40 subunit
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Rpn11
Regulatory particle non-ATPase 11
p37B, S13, 37B, DmS13
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
JOSEPHIN DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Josd
Josephin domain containing
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
MINDY DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG7332
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG14142
(FlyBase, 2017-)
PPPDE DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG7222
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG12231
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
SERINE-TYPE OTU DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG3251
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Louis et al., 2015, Zhang et al., 2012, Rawlings and Barrett, 1996-)
otu
ovarian tumor
fs(1)231, K, fs(1)M101
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Louis et al., 2015, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
UCH DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
caly
calypso
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Uch
Ubiquitin carboxy-terminal hydrolase
dUCH, ubiquitin carboxyl terminal hydrolase, UCH-D
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Uch-L5
Ubiquitin carboxy-terminal hydrolase L5
Uch-L3, p37A, UCHL5, Ubiquitin C-terminal hydrolase
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Uch-L5R
Uch-L5-related
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
USP DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CYLD
Cylindromatosis
dCYLD
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
DUBAI
Deubiquitinating apoptotic inhibitor
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
faf
fat facets
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
not
non-stop
l(3)02069
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
puf
puffyeye
Usp34
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
scny
scrawny
dUSP36, Usp36, mule, l(3)02331, emperor's thumb
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp1
Ubiquitin specific protease 1
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp2
Ubiquitin specific protease 2
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp5
Ubiquitin specific protease 5
leon, DmUSP5
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp7
Ubiquitin-specific protease 7
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp8
Ubiquitin specific protease 8
Ubpy
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp10
Ubiquitin specific protease 10
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp12-46
Ubiquitin-specific protease 12/46
Usp12
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp14
Ubiquitin specific protease 14
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp15-31
Ubiquitin specific protease 15/31
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp16-45
Ubiquitin specific protease 16/45
Usp45
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp20-33
Ubiquitin specific protease 20/33
Usp33
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp30
Ubiquitin specific protease 30
dUSP30
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp32
Ubiquitin specific protease 32
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
Usp47
Ubiquitin specific protease 47
Ubp64E, E(var)3-64E, Ubp64, D-UBP-64E
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
VIRAL TEGUMENT-LIKE DEUBIQUITINASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG42529
(FlyBase, 2017-)
Vtld
Viral tegument-like deubiquitinase
ms(3)76Ca
(Erven et al., 2022)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
DUB
DEUBIQUITINASES
Deubiquitylase
Deubiquitinating Enzymes
De-ubiquitinases
Deubiquitinating peptidases
Deubiquitinating isopeptidases
Ubiquitin proteases
Ubiquitin hydrolases
Ubiquitin isopeptidases
DUBs
UPS
Secondary FlyBase ID(s)
References (11)