FB2024_02 , released April 23, 2024
Gene Group - Macromolecular Complex: MALE SPECIFIC LETHAL COMPLEX
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General Information
Name
MALE SPECIFIC LETHAL COMPLEX
Species
D. melanogaster
Symbol
MSL
FlyBase ID
FBgg0000283
Date last reviewed
2023-08-08
Number of members
7
Description
Description
The Male Specific Lethal (MSL) complex is a chromatin modifying complex composed of five protein subunits and two non-coding RNAs. MSL is involved in X chromosome dosage compensation in males. (Adapted from FBrf0228243).
Notes on Group
Source Material
The MALE SPECIFIC LETHAL COMPLEX Gene Group has been compiled using the following publication(s): Lucchesi and Kuroda, 2015, Hallacli et al., 2012, and Franke and Baker, 1999 .
Key Gene Ontology (GO) terms
Molecular Function
chromatin binding
Biological Process
sex-chromosome dosage compensation
Cellular Component
MSL complex
Related Gene Groups
Parent group(s)
CHROMATIN MODIFYING COMPLEXES
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
lncRNA:roX1
long non-coding RNA on the X 1
roX1, roX, RNA on the X 1, yang, RNA on the X1
(Lucchesi and Kuroda, 2015, Franke and Baker, 1999)
lncRNA:roX2
long non-coding RNA on the X 2
roX2, roX, RNA on the X 2, RNA on the X2
(Lucchesi and Kuroda, 2015, Hallacli et al., 2012, Franke and Baker, 1999)
mle
maleless
nap, napts, no-action-potential, no action potential, male lethal
(Lucchesi and Kuroda, 2015, Hallacli et al., 2012)
mof
males absent on the first
max, dMOF, males absent on first, males-absent on the X
(Lucchesi and Kuroda, 2015, Hallacli et al., 2012)
msl-1
male-specific lethal 1
MSL1, MSL
(Lucchesi and Kuroda, 2015, Hallacli et al., 2012, Franke and Baker, 1999)
msl-2
male-specific lethal 2
MSL2, MSL, kmA
(Lucchesi and Kuroda, 2015, Franke and Baker, 1999)
msl-3
male-specific lethal 3
MSL3, MSL, mle3
(Lucchesi and Kuroda, 2015, Hallacli et al., 2012, Franke and Baker, 1999)
External Data
Synonyms and Secondary IDs
Synonym(s)
MSL
MALE SPECIFIC LETHAL COMPLEX
Compensasome
Dosage compensation complex
MSL complex
Secondary FlyBase ID(s)
References (4)