Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.
Selected publications for background information: Upstream Regulation of the Hippo Size Control Pathway (FBrf0214165), Hippo Gains Weight: Added Insights and Complexity to Pathway Control (FBrf0224870), Mechanisms of Hippo pathway regulation (FBrf0230577), Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway (FBrf0236564), Upstairs, downstairs: spatial regulation of Hippo signalling (FBrf0238869).
Only genes that lie upstream of or directly influence yki cytosolic retention have been included in Hippo Signaling Pathway gene groups. Nuclear factors that regulate yki-mediated transcription or DNA-binding transcription factors that act with yki such as sd, tsh and hth (FBrf0209052) have not been included.
| molecular function | biological process | cellular component |
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[Illustration - Hippo signaling regulates growth in Drosophila and mice. (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Hip1)
[Illustration - Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Hip2)
[Reactome Pathway - Hippo/Warts pathway](https://reactome.org/PathwayBrowser/#/R-DME-390146&PATH=R-DME-5252538)
[KEGG pathway - Hippo signaling pathway - fly](https://www.kegg.jp/entry/pathway/dme04391)
