The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of
lz and
pros.
sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (
boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from
FBrf0127283 and
FBrf0221727).