FB2024_02 , released April 23, 2024
Gene Group - Pathway: Hedgehog Signaling Pathway
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General Information
Name
Hedgehog Signaling Pathway
Species
D. melanogaster
Symbol
HH-SMO
FlyBase ID
FBgg0000978
Date last reviewed
2023-02-08
Number of members
97
Description
Description
The hedgehog signaling pathway is initiated by hedgehog (hh) ligand binding to the extracellular domain of patched receptor (ptc), leading to the derepression of smoothened (smo) activity. Activation of the atypical GPCR smo results in the accumulation of the transcriptional activator form of cubitus interruptus (ci) and the derepression/activation of hh target genes. In the absence of hh, smo is repressed by ptc and ci is processed to a truncated repressor form. (Adapted from FBrf0220683 and FBrf0231236).
Notes and selected reviews

Selected publications for background information: Hedgehog signalling (FBrf0230846), Drosophila Segment Polarity Mutants and the Rediscovery of the Hedgehog Pathway Genes (FBrf0231236), Smoothened regulation in response to Hedgehog stimulation (FBrf0231240), The emerging roles of phosphatases in Hedgehog pathway (FBrf0236706), The mechanisms of Hedgehog signalling and its roles in development and disease (FBrf0221909) and Regulation of Hedgehog signaling: a complex story (FBrf0174381).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
Hedgehog Production
Hedgehog Signaling Pathway Core Components
Negative Regulators of Hedgehog Signaling Pathway
Positive Regulators of Hedgehog Signaling Pathway
Protein Complex group(s)
HEDGEHOG SIGNALING COMPLEX
Physical Interaction Network
Members (97)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Hedgehog Production
Hedgehog Signaling Pathway Core Components
Negative Regulators of Hedgehog Signaling Pathway
Positive Regulators of Hedgehog Signaling Pathway
External Data
Other resource(s)

[Illustration - The Hedgehog pathway in Drosophila and vertebrates (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Hed)

[Wikipathways - Hedgehog Signaling Pathway (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP492 )

[Animation - The Hedgehog signaling pathway in Drosophila (Wolpert, Tickle & Martinez Arias:Principles of Development International 5e)](https://www.youtube.com/watch?v=w1xXD9kss2w&t=2s)

[Reactome Pathway - Hedgehog pathway](https://reactome.org/PathwayBrowser/#/R-DME-209392&PATH=R-DME-5252538)

[KEGG pathway - Hedgehog signaling pathway - fly](https://www.genome.jp/kegg-bin/show_pathway?dme04341)

[Gene List - Genes downstream of hedgehog (The Interactive Fly)](http://www.sdbonline.org/sites/fly/aignfam/sgmtplty.htm#Hedgehog)

Synonyms and Secondary IDs
Synonym(s)
HH-SMO
Hedgehog Signaling Pathway
Smoothened signaling pathway
Secondary FlyBase ID(s)
References (164)