In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (
Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (
dl or
Dif) transcription factor. Positive regulators of Toll-NF-κB Signaling lead to the increased nuclear accumulation of the NF-κB proteins and regulated expression of target genes. (Adapted from
FBrf0091014 and
FBrf0223077).