FB2024_02 , released April 23, 2024
Gene Group - Pathway: Imd Signaling Pathway
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General Information
Name
Imd Signaling Pathway
Species
D. melanogaster
Symbol
IMD
FlyBase ID
FBgg0001194
Date last reviewed
2024-03-04
Number of members
77
Description
Description
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
Notes and selected reviews

Selected publications for background information: Beyond immunity: The Imd pathway as a coordinator of host defense, organismal physiology and behavior (FBrf0238555), The Drosophila imd signaling pathway (FBrf0224587), The Drosophila IMD pathway in the activation of the humoral immune response (FBrf0223070).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
Imd Signaling Pathway Core Components
Negative Regulators of Imd Signaling Pathway
Positive Regulators of Imd Signaling Pathway
Other related group(s)
ANTIMICROBIAL PEPTIDES
PEPTIDOGLYCAN RECOGNITION PROTEINS
Physical Interaction Network
Members (77)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Imd Signaling Pathway Core Components
Negative Regulators of Imd Signaling Pathway
Positive Regulators of Imd Signaling Pathway
External Data
Other resource(s)

[Illustration - (The Interactive Fly)](https://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Imm1)

[Reactome Pathway - Imd Pathway](https://reactome.org/PathwayBrowser/#/R-DME-209459&PATH=R-DME-5252538)

[KEGG Pathway - Toll and Imd signaling pathway - Drosophila melanogaster](https://www.genome.jp/kegg-bin/show_pathway?map=dme04624)

[Wikipathways - Toll, IMD, JAK/STAT Pathways for Immune Response to Pathogens (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP3830 )

[Wikipathways - Humoral Immune Response to Fungal and Bacterial Pathogens (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP3660 )

Synonyms and Secondary IDs
Synonym(s)
IMD
Imd Signaling Pathway
Immune deficiency pathway
peptidoglycan recognition protein signaling pathway
Secondary FlyBase ID(s)
References (81)