FB2024_02 , released April 23, 2024
Gene Group: DNA POLYMERASES
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General Information
Name
DNA POLYMERASES
Species
D. melanogaster
Symbol
DNAPOL
FlyBase ID
FBgg0001200
Date last reviewed
2019-07-18
Number of members
19
Description
Description
Multiple DNA polymerases are required for DNA replication in eukaryotic cells. The alpha-primase, delta and epsilon polymerases exist as multi-subunit complexes and are responsible for the bulk of nuclear DNA synthesis. Other specialized polymerases (including eta, iota, theta, zeta and Rev1) are required for nuclear DNA repair and/or translesion DNA synthesis. DNA polymerase gamma is responsible for the replication and repair of mitochondrial DNA. (Adapted from PMID:30005324.)
Notes on Group

D. melanogaster appear to lack orthologs of the following human DNA polymerases: BETA, DELTA, KAPPA, LAMBDA, MU, NU, Tdt and PrimPol.

Source Material
The DNA POLYMERASES Gene Group has been compiled using the following publication(s): Marygold et al., 2020 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-directed DNA polymerase activity
Biological Process
DNA-templated DNA replication
Cellular Component
Enzymatic activity
Enzyme name (EC)
DNA-directed DNA polymerase (2.7.7.7)
Related Gene Groups
Component group(s)
DNA POLYMERASE ALPHA-PRIMASE
DNA POLYMERASE DELTA
DNA POLYMERASE EPSILON
DNA POLYMERASE ETA
DNA POLYMERASE GAMMA
DNA POLYMERASE IOTA
DNA POLYMERASE REV1
DNA POLYMERASE THETA
DNA POLYMERASE ZETA
Other related group(s)
DNA POLYMERASE CATALYTIC SUBUNITS
Members (19)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
DNA POLYMERASE ALPHA-PRIMASE
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolA1
DNA polymerase alpha subunit 1
DNApol-alpha180, DNA polymerase α, DNApol-α, DNApol-α180, POLA
(Marygold et al., 2020, FlyBase, 2017-)
PolA2
DNA polymerase alpha subunit 2
DNApol-α73, DNA polymerase α, Polα, Polα 73kDa, DNA polymerase α 73kD
(Marygold et al., 2020, FlyBase, 2017-)
Prim1
DNA primase subunit 1
DNApol-α50, DNA polymerase α, DNApol-alpha50, pol α, Dpri50
(Marygold et al., 2020, FlyBase, 2017-)
Prim2
DNA primase subunit 2
DNAprim, l(3)j10B2, DNA primase, DNA polymerase α 60kD
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE DELTA
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolD1
DNA polymerase delta subunit 1
DNApol-delta, DNApol-δ, Polδ, DNA polymerase delta, l(3)72Ac
(Marygold et al., 2020, FlyBase, 2017-)
PolD2
DNA polymerase delta subunit 2
Pol31, BcDNA:HL03874
(Marygold et al., 2020, FlyBase, 2017-)
PolD3
DNA polymerase delta subunit 3
BG:DS07295.3, pol32, rd, reduced
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE EPSILON
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Chrac-14
Chromatin accessibility complex 14kD protein
CHRAC14, PolE3, mary, CHRAC
(Marygold et al., 2020, FlyBase, 2017-)
PolE1
DNA polymerase epsilon subunit 1
DNApol-epsilon, DNApol-ε, DNApol-ε255, DNA polymerase ε, Polε
(Marygold et al., 2020, FlyBase, 2017-)
PolE2
DNA polymerase epsilon subunit 2
DNApol-ε58
(Marygold et al., 2020, FlyBase, 2017-)
PolE4
DNA polymerase epsilon subunit 4
Mes4, NF-Yc
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE ETA
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolH
DNA polymerase eta
DNApol-eta, drad30A, DNApol-η, dPolη
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE GAMMA
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolG1
DNA polymerase gamma subunit 1
tamas, tam, DNApol-γ125, pol γ-α, l(2)34Dc
(Marygold et al., 2020, FlyBase, 2017-)
PolG2
DNA polymerase gamma subunit 2
l(2)34De, pol γ-β, l(2)br16, MtPolB, DNApol-γ
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE IOTA
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolI
DNA polymerase iota
DNApol-iota, drad30B, DNApol-ι
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE REV1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Rev1
DNA polymerase Rev1
dRev1
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE THETA
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolQ
DNA polymerase theta
mus308, mutagen-sensitive 308, Pol θ
(Marygold et al., 2020, FlyBase, 2017-)
DNA POLYMERASE ZETA
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolD2
DNA polymerase delta subunit 2
Pol31, BcDNA:HL03874
(Marygold et al., 2020, FlyBase, 2017-)
PolD3
DNA polymerase delta subunit 3
BG:DS07295.3, pol32, rd, reduced
(Marygold et al., 2020, FlyBase, 2017-)
PolZ1
DNA polymerase zeta subunit 1
mus205, DNApol-ζ, mus-205, DmREV3, mutagen-sensitive 205
(Marygold et al., 2020, FlyBase, 2017-)
PolZ2
DNA polymerase zeta subunit 2
rev7, DmREV7
(Marygold et al., 2020, FlyBase, 2017-)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
DNAPOL
DNA POLYMERASES
Secondary FlyBase ID(s)
References (3)