FB2024_02 , released April 23, 2024
Gene Group - Macromolecular Complex: ADA COMPLEX
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General Information
Name
ADA COMPLEX
Species
D. melanogaster
Symbol
ADAC
FlyBase ID
FBgg0001747
Date last reviewed
Number of members
4
Description
Description
The Ada2/Gcn5/Ada3 transcription activator (ADA) complex is a Gcn5-containing histone acetyltransferase complex that regulates transcription by acetylating core histones, preferentially histone H3 and nucleosomal substrates. (Adapted from FBrf0242086, FBrf0247978 and FBrf0248705).
Notes on Group

Unlike yeast ADA complex the metazoan ADA complex contains a typical histone acetyltransferase (HAT) module (subunits Ada2b, Gcn5, Ada3 and Sgf29) of SAGA complex that functions as an independant complex with out any additional subunits. (FBrf0242086).

In Dmel there are two splice isoforms of Ada2b and the long Ada2b isoform is the exclusive subunit of both SAGA and ADA complex (FBrf0242086).

Source Material
The ADA COMPLEX Gene Group has been compiled using the following publication(s): Helmlinger et al., 2021, Torres-Zelada and Weake, 2021, and Soffers et al., 2019 .
Key Gene Ontology (GO) terms
Molecular Function
histone acetyltransferase activity
Biological Process
regulation of transcription by RNA polymerase II
Cellular Component
ADA complex
Enzymatic activity
Enzyme name (EC)
histone acetyltransferase (2.3.1.48)
Related Gene Groups
Parent group(s)
GCN5-CONTAINING COMPLEXES
Protein Complex group(s)
ATAC COMPLEX
CHAT COMPLEX
SAGA COMPLEX
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Ada2b
transcriptional Adaptor 2b
dAda2b
(Helmlinger et al., 2021, Torres-Zelada and Weake, 2021, Soffers et al., 2019)
Ada3
transcriptional Adaptor 3
dAda3, dik, diskette
(Helmlinger et al., 2021, Torres-Zelada and Weake, 2021, Soffers et al., 2019)
Gcn5
Gcn5 acetyltransferase
dGcn5, Pcaf, KAT, dmGCN5, dKAT2
(Helmlinger et al., 2021, Torres-Zelada and Weake, 2021, Soffers et al., 2019)
Sgf29
SAGA-associated factor 29kDa
dSgf29
(Helmlinger et al., 2021, Torres-Zelada and Weake, 2021, Soffers et al., 2019)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ADAC
Ada2/Gcn5/Ada3 transcription activator (ADA) complex
ADA COMPLEX
Secondary FlyBase ID(s)
References (4)