Gene Group - Pathway: cGAS-STING Signaling Pathway

General Information

Name

cGAS-STING Signaling Pathway

Species

D. melanogaster

Symbol

CGAS-STING

FlyBase ID

FBgg0001792

Date last reviewed

2023-11-07

Number of members

Description

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an anti-viral pattern recognition pathway. In Drosophila, cyclic GMP-AMP (cGAMP) synthases are activated by viral infection, cGAMP is in turn detected by STING ultimately resulting in the activation the NF-κB-like factor Rel and its translocation into the nucleus to activate the transcription of anti-viral genes. (Adapted from FBrf0252868.)

Notes and selected reviews

Selected publications for background information: cGAS-like receptor-mediated immunity: the insect perspective (FBrf0252868) and The antiviral role of NF-κB-mediated immune responses and their antagonism by viruses in insects (FBrf0253361).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)

Related Gene Groups

Component group(s)

cGAS-STING Signaling Pathway Core Components

Positive Regulators of cGAS-STING Signaling Pathway

Physical Interaction Network

Members (7)

For all members: