Jheh, JH, epoxide hydrolase, EH
Please see the JBrowse view of Dmel\Jheh1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jheh1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Jheh1 in JBrowse2-86
2-92.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Ortholog of B. mori juvenile-hormone-related gene (involved in JH biosynthesis, metabolism or signaling).
Juvenile hormone metabolisms in two lines of adults is studied under normal conditions and after a short period of heat stress.
Heat stress results in delay of oviposition and a decrease in juvenile hormone hydrolysis and fertility, which lasted several days after heat treatment.
The course of changes in the activities of enzymes degrading juvenile hormone (JH) during development is studied and the possible role of the proteins in the regulation of JH titre in critical developmental periods and in reproduction are investigated.
Radiometric assay of JH-hydrolysing activity identified 2 activities: those encoded by Jhe and Jheh. Juvenile hormone hydrolytic activity in larvae is largely due to Jheh.
Abnormally low levels of juvenile hormone are synthesized in ap mutants.
Stage 8 and 9 oocytes transplanted into juvenile hormone (JH) deficient males and females were found to degenerate unless a JH analogue, ZR-515, was applied to the host shortly after implantation. These results suggest that JH is required for the initiation and continuation of vitellogenic uptake and oocyte development.
Source for merge of: Jheh BEST:GH06241
Source for merge of: CG15101 BEST:GH06241
Source for merge of Jheh BEST:GH06241 was sequence comparison ( date:020814 ).
Source for merge of CG15101 BEST:GH06241 was a shared cDNA (GH06241) ( date:011030 ).
The non-sequence localized gene 'Exh' (FBgn0004476) has been obsoleted and the associated information and papers (FBrf0125491, FBrf0053958, FBrf0047035, FBrf0043802, FBrf0033699) have been transferred to the three Jheh paralogs, Jheh1, Jheh2, Jheh3. This is because 'Exh' represented an 'epoxide hydrolase' (EC:3.3.2.3) activity, which a later paper (FBrf0254146) specifically linked to the Jheh paralogs.