FB2024_02 , released April 23, 2024
Gene: Dmel\arg
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General Information
Symbol
Dmel\arg
Species
D. melanogaster
Name
arginase
Annotation Symbol
CG18104
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023535
Gene Model Status
Current
Stock Availability
27 publicly available
Enzyme Name (EC)
arginase (3.5.3.1)
Gene Summary
arginase (arg) encodes an enzyme that converts arginine into ornithine. Lack of arg produces a developmental embryonic delay. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

EG:171D11.4 , EG:65F1.3

Key Links
Genomic Location
Cytogenetic map
1B7-1B8
Sequence location
Recombination map
1-0
RefSeq locus
NC_004354 REGION:509435..528028
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables arginase activity
inferred from electronic annotation with InterPro:IPR014033
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P07824
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000144386
(GO Reference Genome Project, 2011-)
enables manganese ion binding
inferred from biological aspect of ancestor with PANTHER:PTN000144386
(GO Reference Genome Project, 2011-)
enables metal ion binding
inferred from electronic annotation with InterPro:IPR006035, InterPro:IPR014033
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in arginine catabolic process to ornithine
inferred from sequence or structural similarity with UniProtKB:P07824
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000144386
(GO Reference Genome Project, 2011-)
involved_in arginine metabolic process
inferred from electronic annotation with InterPro:IPR014033
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000144386
(GO Reference Genome Project, 2011-)
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000144387
(GO Reference Genome Project, 2011-)
located_in mitochondrial outer membrane
inferred from sequence or structural similarity with UniProtKB:P07824
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
arginase activity
H2O + L-arginine = L-ornithine + urea (3.5.3.1)
RHEA 20569:
Summaries
Gene Snapshot
arginase (arg) encodes an enzyme that converts arginine into ornithine. Lack of arg produces a developmental embryonic delay. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CARBON-NITROGEN HYDROLASES OF LINEAR AMIDINES -
Carbon-Nitrogen hydrolases of linear amidines catalyze the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\arg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O76895)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
arg-RA
FBtr0070088
NM_080136
1243
351
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
arg-PA
FBpp0070083
39.1
351
7.21
O76895
NP_524875
AAF45516
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\arg using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.62

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
embryonic stage 16
embryonic/larval fat body
(Samson, 2000)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Samson, 2000)
adult stage
head
(Samson, 2000)
Additional Descriptive Data

Northern analysis reveals that arg transcript is expressed at low levels until embryonic stage 15, when expression levels begin to increase. Expression levels peak during the first larval instar, and levels remain high through the adult stage.

(Samson, 2000)
Marker for
 
fat body primordium
(Samson, 2000)
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\arg in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of arg
Transgenic constructs containing regulatory region of arg
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\ARG2
14 of 14
Yes
Yes
1  
Hsap\ARG1
13 of 14
No
Yes
Hsap\AGMAT
2 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Arg1
13 of 14
Yes
Yes
Rnor\Arg2
13 of 14
Yes
Yes
Rnor\Agmat
2 of 14
No
Yes
Mus musculus (laboratory mouse) (3)
Mmus\Arg2
14 of 14
Yes
Yes
Mmus\Arg1
12 of 14
No
Yes
Mmus\Agmat
2 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\arg2
11 of 13
Yes
Yes
Xtro\arg1
7 of 13
No
Yes
Xtro\per2
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\arg2
14 of 14
Yes
Yes
Drer\arg1
13 of 14
No
Yes
Drer\agmat
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\argn-1
11 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP008783
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\ARGAH1
5 of 13
Yes
Yes
Atha\ARGAH2
5 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CAR1
12 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\aru1
11 of 12
Yes
Yes
Spom\car1
11 of 12
Yes
Yes
Spom\SPAC11D3.09
2 of 12
No
Yes
Spom\SPAPB24D3.03
2 of 12
No
Yes
Spom\SPBC8E4.03
2 of 12
No
Yes
Escherichia coli (enterobacterium) (1)
Ecol\speB
5 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:arg. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    ARG1; arginase 1
    model of  hyperargininemia
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ARG2; arginase 2
    14 of 14
    107830
         
        ARG1; arginase 1
        13 of 14
        608313
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        MIST Molecular Interaction Search Tool
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-0
        Cytogenetic map
        1B7-1B8
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        1B7-1B8
        Limits computationally determined from genome sequence between P{EP}svrEP356&P{EP}argEP452 and P{EP}DreddEP1412&P{EP}Suv4-20EP1216a
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        1B-1B
        (Samson, 2000.1.25)
        Experimentally Determined Recombination Data
        Location

        1-0

        (FlyBase, 2016)

        1-0.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (27)
        Genomic Clones (20)
        cDNA Clones (11)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: arginase CG18104

            (Bayraktaroglu, 2000.4.12)
            Additional comments
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (6)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 76 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            References (53)