Please see the JBrowse view of Dmel\PIP82 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Gene model reviewed during 5.46
4.0 (sequence analysis)
There is only one protein coding transcript and one polypeptide associated with this gene
1171 (aa)
Phosphorylated by aPKC which lowers lipid affinity and promotes dissociation from the cell cortex (PubMed:26481050, PubMed:32579558). In the photoreceptor cells, aPKC-mediated phosphorylation leads to its displacement from the stalk apical cortex and thus restricts its localization to the rhabdomeric apical cortex where it functions (PubMed:32579558). Dephosphorylation appears to be light-dependent (PubMed:9697866).
The phospho-regulated basic and hydrophobic (PRBH) motif is sufficient and important for interaction with phospholipids permitting cortical localization (PubMed:26481050). Phosphorylation of the PRBH motif by aPKC inhibits the association of the protein with the cortical membrane (PubMed:26481050, PubMed:32579558).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PIP82 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression is first observed around 48hr APF in photoreceptor cells and is maintained post-eclosion only in photoreceptors.
JBrowse - Visual display of RNA-Seq signals
View Dmel\PIP82 in JBrowse1-23
1-23.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.