FB2024_04 , released June 25, 2024
Gene: Mmus\Cd8a
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General Information
Symbol
Mmus\Cd8a
Species
M. musculus
Name
CD8 antigen, alpha chain
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0026406
Gene Model Status
Not Applicable
Stock Availability
233 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

mCD8, CD8, Cd8a, lymphocyte protein CD8, mDC8

Key Links
Foreign Gene Data

Foreign sequence; species == Mus musculus; gene == Cd8a; MGI:88346.

(FlyBase Curators, 1992-)
Function

Information on product gene function for non-D. melanogaster species is no longer provided by FlyBase.

Up-to-date information on gene product function can be found by searching UniProtKB for proteins or RNAcentral for non-coding RNAs.

Summaries
Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Experimentally Determined Structures
Crossreferences
Comments on Gene Model
Sequence Ontology: Class of Gene
engineered_foreign_gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Mmus\Cd8a using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    NA

    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Mmus\Cd8a in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 1 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 155 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Mmus\Cd8a
    Transgenic constructs containing regulatory region of Mmus\Cd8a
    Aberrations (Deficiencies and Duplications) ( 0 )
    Inferred from experimentation ( 0 )
    Inferred from location ( 0 )
      Variants
      Variant Molecular Consequences
      Alleles Representing Disease-Implicated Variants
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Phenotype manifest in
      Allele
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Human Orthologs (via DIOPT v9.1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      Domainoid
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      SonicParanoid
      Alignment
      Complementation?
      Transgene?
      Homo sapiens (Human) (0)
      Model Organism Orthologs (via DIOPT v9.1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      Domainoid
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      SonicParanoid
      Alignment
      Complementation?
      Transgene?
      Drosophila melanogaster (Fruit fly) (0)
      Other Organism Orthologs (via OrthoDB)
      Data provided directly from OrthoDB:Mmus\Cd8a. Refer to their site for version information.
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Summary of Genetic Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (233)
        Genomic Clones (0)
         
          cDNA Clones (0)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Cell Line Information
                    Publicly Available Cell Lines
                     
                      Other Stable Cell Lines
                       
                        Other Comments
                        Relationship to Other Genes
                        Source for database merge of
                        Additional comments
                        Nomenclature History
                        Source for database identify of
                        Nomenclature comments
                        Etymology
                        Synonyms and Secondary IDs (16)
                        Reported As
                        Symbol Synonym
                        CD8
                        (Fernandez-Funez et al., 2015, Butí et al., 2014, Roy et al., 2014, Fitzsimons et al., 2013, Jukam et al., 2013, Li et al., 2013, Rousso et al., 2013, Yamanaka et al., 2013, Chen and Ganetzky, 2012, Gault et al., 2012, Moraru et al., 2012, Rawson et al., 2012, Song and Lu, 2012, Zhang et al., 2012, Acebes et al., 2011, Charlton-Perkins et al., 2011, Depetris-Chauvin et al., 2011, Hasegawa et al., 2011, Kazama et al., 2011, Pappu et al., 2011, Roy et al., 2011, Schulte et al., 2011, Stowers, 2011, Thum et al., 2011, Yuan et al., 2011, Ai et al., 2010, Assaker et al., 2010, Boerner and Duch, 2010, Bulgakova et al., 2010, Fernandez-Funez et al., 2010, Haussmann and Soller, 2010, Marie et al., 2010, Rousset et al., 2010, Schoenmann et al., 2010, Sitaraman et al., 2010, Young and Armstrong, 2010, Zeng et al., 2010, Ahmad et al., 2009, Bottenberg et al., 2009, Choi et al., 2009, Fox and Spradling, 2009, Glavic et al., 2009, Iijima-Ando et al., 2009, Krashes et al., 2009, Mendes et al., 2009, Mitri et al., 2009, Parrish et al., 2009, Sakurai et al., 2009, Tuxworth et al., 2009, Belenkaya et al., 2008, Benetka et al., 2008, Fradkin et al., 2008, Iijima et al., 2008, Nässel et al., 2008, Takashima et al., 2008, Vömel and Wegener, 2008, Augustin et al., 2007, Benton et al., 2007, Benton et al., 2007, Bianco et al., 2007, de Velasco et al., 2007, Grieder et al., 2007, Hattori et al., 2007, Jefferis et al., 2007, Jones et al., 2007, Jones et al., 2007, Liu et al., 2007, Millard et al., 2007, Parrish et al., 2007, Roy et al., 2007, Arya et al., 2006, Ashraf et al., 2006, Bernard et al., 2006, Betschinger et al., 2006, Hyun et al., 2006, Jafar-Nejad et al., 2006, Larsen et al., 2006, Mahr and Aberle, 2006, Metzstein and Krasnow, 2006, Parker, 2006, Soller et al., 2006, Srahna et al., 2006, Honjo and Furukubo-Tokunaga, 2005, Nicolas and Preat, 2005, Roegiers et al., 2005, Tonning et al., 2005, Wilson and Laurent, 2005, Zhu et al., 2005, Mudher et al., 2004, Renault et al., 2004, Wang and Struhl, 2004, Dow et al., 2003, Lee and Luo, 1999)
                        CD8a
                        (Povellato et al., 2014, Petersen and Stowers, 2011)
                        CD8m
                        (Kim et al., 2006)
                        Cd8
                        (Yu et al., 2009)
                        Cd8a
                        (Alenius, 2013.11.1, Hadjieconomou et al., 2011)
                        Mmus\Cd8a
                        (Alenius, 2013.11.1)
                        Mus\Cd8a
                        cd8
                        (Jepson et al., 2013, Hadjieconomou et al., 2011, Boerner and Duch, 2010, Kolodziejczyk et al., 2008, Bazigou et al., 2007, McBrayer et al., 2007, Pereanu and Hartenstein, 2006, Chotard et al., 2005)
                        mCD8
                        (Oswald et al., 2015, West et al., 2015, Awasaki et al., 2014, Awasaki et al., 2014, Awasaki et al., 2014, Jeibmann et al., 2014, Machamer et al., 2014, Mauss et al., 2014, Roy et al., 2014, Sha et al., 2014, Fregoso Lomas et al., 2013, Nagy et al., 2013, Picchio et al., 2013, Shirangi et al., 2013, Berger et al., 2012, Chen et al., 2012, Chen et al., 2012, Edwards et al., 2012, Helmstadter et al., 2012, Lai et al., 2012, Manning et al., 2012, Stewart et al., 2012, Awasaki et al., 2011, Chang et al., 2011, Chiang et al., 2011, Daniels et al., 2011, Danjo et al., 2011, Ding et al., 2011, Jayanandanan et al., 2011, Kuzina et al., 2011, Narbonne-Reveau et al., 2011, Orihara-Ono et al., 2011, Pandey et al., 2011, Petersen and Stowers, 2011, Raghu and Borst, 2011, Rossetto et al., 2011, Roy et al., 2011, Schnakenberg et al., 2011, Stephan et al., 2011, Stowers, 2011, Thum et al., 2011, Viktorin et al., 2011, Agrawal et al., 2010, Alekseyenko et al., 2010, Bates et al., 2010, Blanco et al., 2010, Boerner and Duch, 2010, Busch and Tanimoto, 2010, Certel et al., 2010, Chou et al., 2010, Gong et al., 2010, Hekmat-Scafe et al., 2010, Kim et al., 2010, Kosmidis et al., 2010, Kremer et al., 2010, Li et al., 2010, Lin et al., 2010, Liu et al., 2010, Lone et al., 2010, Masuda-Nakagawa et al., 2010, Mathur et al., 2010, Mathur et al., 2010, Nagoshi et al., 2010, Padash-Barmchi et al., 2010, Potter et al., 2010, Rallis et al., 2010, Roch et al., 2010, Tsuda et al., 2010, Tsurudome et al., 2010, Usha and Shashidhara, 2010, Weng et al., 2010, White et al., 2010, Yagi et al., 2010, Young and Armstrong, 2010, Zheng et al., 2010, Bai et al., 2009, Bottenberg et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Johard et al., 2009, Li et al., 2009, Lu et al., 2009, Orso et al., 2009, Parrish et al., 2009, Prakash et al., 2009, Rayburn et al., 2009, Sun et al., 2009, Udolph et al., 2009, Awasaki et al., 2008, Berger et al., 2008, Hoopfer et al., 2008, Kolodziejczyk et al., 2008, Kwon et al., 2008, Poeck et al., 2008, Satoh et al., 2008, Assa-Kunik et al., 2007, Bello et al., 2007, Bidla et al., 2007, Ebacher et al., 2007, Gorczyca et al., 2007, Grueber et al., 2007, Hattori et al., 2007, Joly et al., 2007, Komiyama et al., 2007, Krzemień et al., 2007, Kurtovic et al., 2007, Laurençon et al., 2007, Lin et al., 2007, Mandal et al., 2007, Matthews et al., 2007, Murakami et al., 2007, Roy et al., 2007, Sakurai et al., 2007, Schnorrer et al., 2007, Shang et al., 2007, Spletter et al., 2007, Thomas and van Meyel, 2007, Whited et al., 2007, Ye et al., 2007, Ang et al., 2006, Bello et al., 2006, Benton et al., 2006, Berdnik et al., 2006, Boyle et al., 2006, Brankatschk and Dickson, 2006, Cafferty et al., 2006, Chen et al., 2006, Choi et al., 2006, Fayyazuddin et al., 2006, Friedman and Perrimon, 2006, Friggi-Grelin et al., 2006, Girard et al., 2006, Hewes et al., 2006, Iyengar et al., 2006, Kamikouchi et al., 2006, Keene et al., 2006, Khodosh et al., 2006, Kim et al., 2006, Kobayashi et al., 2006, Lai and Lee, 2006, Li et al., 2006, Long et al., 2006, Mathews et al., 2006, McDonald et al., 2006, Parrish et al., 2006, Pitman et al., 2006, Sweeney et al., 2006, Wang et al., 2006, Ward et al., 2006, Zhu et al., 2006, Zhu et al., 2006, Apitz et al., 2005, Goldman et al., 2005, Hassan et al., 2005, Martini and Davis, 2005, Yu et al., 2005, Keene et al., 2004, Komiyama et al., 2004, Li et al., 2004, Mehren and Griffith, 2004, Sugimura et al., 2004, Suster et al., 2004, Sykes et al., 2004, Wang et al., 2004, Williams and Truman, 2004, Zhan et al., 2004, Suster et al., 2003, Fei et al., 2002, Bai et al., 2000, Kiger et al., 2000)
                        mDC8
                        (Basto et al., 2006, Lalevee et al., 2006)
                        mc8
                        (Granell et al., 2011)
                        mcD8
                        (López-Arias et al., 2011)
                        mcd8
                        (Subramanian et al., 2013, Tunstall et al., 2012, Buchon et al., 2010, Liu et al., 2009)
                        Name Synonyms
                        CD8 antigen, alpha chain
                        lymphocyte CD8 protein
                        (Roy et al., 2011)
                        lymphocyte protein CD8
                        (Roy et al., 2014, Roy et al., 2011)
                        Secondary FlyBase IDs
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 3 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          Other crossreferences
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Mouse Genome Database - The international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
                          References (1,249)