FlyBase Gene Report: Dmel\CG17598

General Information

Symbol

Dmel\CG17598

Species

D. melanogaster

Name

Annotation Symbol

CG17598

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031194

Gene Model Status

Current

Stock Availability

4 publicly available

Enzyme Name (EC)

protein-serine/threonine phosphatase (3.1.3.16)

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (3.1.3.43)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

20C1-20C1

Sequence location

X:22,534,831..22,540,383 [-]

Recombination map

1-66

RefSeq locus

NC_004354 REGION:22534831..22540383

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000353228

(GO Reference Genome Project, 2011-)

enables cation binding

inferred from electronic annotation with InterPro:IPR000222

(InterPro Project Members, 2004-)

enables phosphoprotein phosphatase activity

inferred from sequence or structural similarity with HGNC:18583

(Gene Ontology Curators, 2002-)

enables protein serine/threonine phosphatase activity

inferred from electronic annotation with InterPro:IPR015655

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in dephosphorylation

inferred from sequence or structural similarity with HGNC:18583

(Gene Ontology Curators, 2002-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with HGNC:18583

(Gene Ontology Curators, 2002-)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000353228

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with HGNC:18583

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

PPM FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine phosphatase activity

(1) H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate (3.1.3.16)

(2) H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate (3.1.3.16)

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate (3.1.3.43)

RHEA 12669:

Summaries

Gene Group (FlyBase)

PPM FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: Metal-dependent protein phosphatase (PPM) are Mg²⁺- or Mn²⁺-dependent serine/threonine phosphatases. The phosphatase does not require regulatory subunits, but has additional domains that may determine substrate specificity. (Adapted from PMID:11230548 and PMID:19879837).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG17598 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VR62)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG17598-RA

FBtr0077364

NM_134624

2662

651

CG17598-RB

FBtr0333716

NM_001272851

4272

651

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG17598-PA

FBpp0077056

72.9

651

6.42

FBpp0305865

72.9

651

6.42

Q9VR62

NP_001259780

AGB95618

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

651 aa isoforms: CG17598-PA, CG17598-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VR62

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG17598 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG17598_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.87

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG17598 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG17598

View exonic expression by tissue for Dmel\CG17598

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031194

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33140/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031194

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031194

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031194

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17598

Flygut - An atlas of the Drosophila adult midgut

FBgn0031194

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG17598

Transgenic constructs containing regulatory region of CG17598

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)S6kII-ignΔ67-1

(Putz et al., 2004)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG17598^GD9421

viable, with Scer\GAL4^Mef2.PR

CG17598^GD9421

viable, with Scer\GAL4^pnr-MD237

CG17598^GD9421

viable, with Scer\GAL4^tin.CΔ4

CG17598^GD9421

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

CG17598^HMS01812

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\PPM1H

12 of 14

Yes

Hsap\PPM1J

12 of 14

Yes

Hsap\PPM1M

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Ppm1h

12 of 14

Yes

Rnor\Ppm1j

12 of 14

Yes

Rnor\Ppm1m

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Ppm1h

12 of 14

Yes

Mmus\Ppm1j

11 of 14

Yes

Mmus\Ppm1m

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\ppm1h

10 of 13

Yes

Xtro\ppm1j

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (13)

Drer\ppm1h

13 of 14

Yes

Drer\ppm1j

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\ppm-1.H

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP000248

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (60)

Atha\AT1G07160

2 of 13

Yes

Atha\AT1G67820

2 of 13

Yes

Atha\AT2G30020

2 of 13

Yes

Atha\AT3G27140

2 of 13

Yes

Atha\AT4G08260

2 of 13

Yes

Atha\PP2C5

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\PTC1

1 of 13

Yes

Scer\PTC2

1 of 13

Yes

Scer\PTC3

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\ptc1

1 of 12

Yes

Spom\ptc2

1 of 12

Yes

Spom\ptc3

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG17598. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

Nil

2 of 13

Pdp

2 of 13

Pp2C1

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPM1H; protein phosphatase, Mg2+/Mn2+ dependent 1H

12 of 14

616016

PPM1J; protein phosphatase, Mg2+/Mn2+ dependent 1J

12 of 14

609957

PPM1M; protein phosphatase, Mg2+/Mn2+ dependent 1M

6 of 14

608979

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CG17598 - Rab2

pull down, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031194

MIST (protein-protein) - An integrated Molecular Interaction Database

33140

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-66

Cytogenetic map

20C1-20C1

Sequence location

X:22,534,831..22,540,383 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

20C1-20C1

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-66

(FlyBase, 2016)

1-66.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17975

w¹¹¹⁸ PBac{RB}CG17600^e01638 CG17598^e01638

38345

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01812}attP2

VDRC

v32956

w¹¹¹⁸; P{GD9421}v32956

v32955

w¹¹¹⁸; P{GD9421}v32955/TM3

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM14138

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031194

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031194

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG17598

(Nandi et al., 2022, Wu et al., 2020, Kanoh et al., 2015, Appocher et al., 2014, Sopko et al., 2014, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Liu and Lehmann, 2008, Manh et al., 2005, Putz et al., 2004)

PP2C

(Morrison et al., 2000)

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33140

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VR62

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VR62

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VR62

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031194

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33140/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031194

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031194

FlyMine - An integrated database for Drosophila genomics

FBgn0031194

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17598

MARRVEL_MODEL - MARRVEL (model organism gene)

33140

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031194

DroID - A comprehensive database of gene and protein interactions.

FBgn0031194

DRSC - Results frm RNAi screens

FBgn0031194

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG17598_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031194

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031194

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17598

Flygut - An atlas of the Drosophila adult midgut

FBgn0031194

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC016037

MIST (protein-protein) - An integrated Molecular Interaction Database

33140

References (38)

The following external sites may use different assemblies or annotations than FlyBase.

-1.87

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