FlyBase Gene Report: Dmel\CG9962

General Information

Symbol

Dmel\CG9962

Species

D. melanogaster

Name

Annotation Symbol

CG9962

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031441

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

non-specific serine/threonine protein kinase (2.7.11.1)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

23A2-23A2

Sequence location

2L:2,646,577..2,647,720 [-]

Recombination map

2-7

RefSeq locus

NT_033779 REGION:2646577..2647720

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein serine/threonine kinase activity

inferred from direct assay

(Zhang et al., 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000225966

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in endocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000226268

(GO Reference Genome Project, 2011-)

involved_in positive regulation of canonical Wnt signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN008529589

(GO Reference Genome Project, 2011-)

involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN008529589

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000225966

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Zhang et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000225966

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CK1 KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine kinase activity

(1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] (2.7.11.1)

(2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl- [protein] (2.7.11.1)

Summaries

Gene Group (FlyBase)

CK1 KINASES -: The CK1 kinases (Casein Kinase 1 family) share a highly conserved kinase domain. CK1 kinases are serine/threonine kinases with a preference for acidic substrates. The highly variable C-terminal domains are involved in regulating subcellular localization and activity. (Adapted from FBrf0132098, PMID:24825444 and PMID:15722192).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG9962 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VQE3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG9962-RA

FBtr0077743

NM_134853

1144

319

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG9962-PA

FBpp0077423

37.2

319

9.17

Q9VQE3

NP_608697

AAF51232

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VQE3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG9962 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG9962_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.58

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Zhang et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG9962 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG9962

View exonic expression by tissue for Dmel\CG9962

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33448/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031441

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031441

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031441

Flygut - An atlas of the Drosophila adult midgut

FBgn0031441

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG9962

Transgenic constructs containing regulatory region of CG9962

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6008

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG9962^GD14740

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\CSNK1A1L

5 of 14

Yes

Hsap\CSNK1E

5 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Csnk1e

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Csnk1e

5 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\csnk1a1

3 of 13

Yes

Xtro\csnk1d

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (15)

Drer\csnk1da

5 of 14

Yes

Drer\csnk1e

5 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (98)

Cele\C05C12.1

4 of 14

Yes

Cele\C34B2.3

4 of 14

Yes

Cele\csnk-1

4 of 14

Yes

Cele\F33D11.7

4 of 14

Yes

Cele\kin-19

4 of 14

Yes

Cele\kin-20

4 of 14

Yes

Cele\ttbk-4

4 of 14

Yes

Cele\Y47G6A.13

4 of 14

Yes

Cele\C03C10.2

3 of 14

Cele\C08F8.6

3 of 14

Cele\C09B9.4

3 of 14

Yes

Cele\C25H3.1

3 of 14

Yes

Cele\C27D8.1

3 of 14

Cele\C39H7.1

3 of 14

Cele\C44C10.7

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\F22H10.1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Cele\ZC373.3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\C55B6.5

1 of 14

Yes

Cele\F10G8.2

1 of 14

Yes

Cele\F16B12.5

1 of 14

Yes

Cele\F26A1.3

1 of 14

Cele\F56H11.6

1 of 14

Yes

Cele\K09C6.7

1 of 14

Yes

Cele\K09C6.8

1 of 14

Yes

Cele\Y59E9AR.10

1 of 14

Yes

Cele\Y73B6A.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP008476

5 of 12

Yes

4 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\ADK1

5 of 13

Yes

Atha\AT4G08800

5 of 13

Yes

Atha\CKL2

5 of 13

Yes

Atha\ckl3

5 of 13

Yes

Atha\ckl4

5 of 13

Yes

Atha\ckl5

5 of 13

Yes

Atha\ckl7

5 of 13

Yes

Atha\ckl8

5 of 13

Yes

Atha\ckl10

5 of 13

Yes

Atha\ckl12

5 of 13

Yes

Atha\CKL13

5 of 13

Yes

4 of 13

4 of 13

4 of 13

2 of 13

2 of 13

Yes

Atha\AT3G03940

2 of 13

Atha\AT3G13670

2 of 13

Atha\AT5G18190

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\HRR25

5 of 13

Yes

Scer\YCK1

2 of 13

Scer\YCK2

2 of 13

Scer\YCK3

2 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\hhp1

4 of 12

Yes

Spom\hhp2

4 of 12

Yes

Spom\cki1

2 of 12

Spom\cki2

2 of 12

Spom\cki3

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG9962. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (11)

5 of 13

5 of 13

5 of 13

5 of 13

dco

5 of 13

gish

5 of 13

Asator

4 of 13

ball

4 of 13

bsd

2 of 13

Cdc7

2 of 13

CG5790

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CSNK1A1L; casein kinase 1 alpha 1 like

5 of 14

CSNK1E; casein kinase 1 epsilon

5 of 14

600863

CSNK1D; casein kinase 1 delta

4 of 14

600864

ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 2; FASPS2

advanced sleep phase syndrome 2

CSNK1G1; casein kinase 1 gamma 1

4 of 14

606274

CSNK1G3; casein kinase 1 gamma 3

4 of 14

604253

CSNK1A1; casein kinase 1 alpha 1

3 of 14

600505

CSNK1G2; casein kinase 1 gamma 2

3 of 14

602214

TPTEP2-CSNK1E; TPTEP2-CSNK1E readthrough

3 of 14

TTBK1; tau tubulin kinase 1

3 of 14

619415

VRK1; VRK serine/threonine kinase 1

3 of 14

602168

VRK2; VRK serine/threonine kinase 2

3 of 14

602169

VRK3; VRK serine/threonine kinase 3

3 of 14

619771

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

MIST Molecular Interaction Search Tool

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031441

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VQE3

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-7

Cytogenetic map

23A2-23A2

Sequence location

2L:2,646,577..2,647,720 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

23A2-23A2

Limits computationally determined from genome sequence between P{PZ}dpp¹⁰⁶³⁸ and P{EP}EP832

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-7

(FlyBase, 2016)

2-5.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

62148

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05154}attP40

FlyORF

F002560

M{UAS-CG9962.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

M2L-2375

y¹ w¹¹¹⁸; CG9962^SK6 P{neoFRT}40A/CyO-Tb

2LG-1893

y² VhaAC39-1^cho-1 v¹; P{U6-CG9962.NIG.sgRNA}attP40/CyO

VDRC

v108721

P{KK107052}VIE-260B

v36178

w¹¹¹⁸; P{GD14326}v36178/TM3

v342718

P{hsFLP}1, y1 w1118; P{HD_CFD01402}attP40/CyO-GFP

v342753

P{hsFLP}1, y1 w1118; P{HD_CFD01690}attP40/CyO-GFP

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP11482

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031441

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031441

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The CG9962 product phosphorylates the arr protein.

(Zhang et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG9962

(National Institute of Genetics Fly Stocks, 2022-, Thakkar et al., 2022, Wang et al., 2020, Wu et al., 2020, Xu et al., 2020, Japanese National Institute of Genetics, 2012.5.21, Meng et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Zhang et al., 2006, Jia et al., 2005)

Name Synonyms

CKIa-like

(Morrison et al., 2000)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 26 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33448

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF51232

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VQE3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VQE3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VQE3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33448/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031441

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031441

FlyMine - An integrated database for Drosophila genomics

FBgn0031441

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9962

MARRVEL_MODEL - MARRVEL (model organism gene)

33448

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031441

DroID - A comprehensive database of gene and protein interactions.

FBgn0031441

DRSC - Results frm RNAi screens

FBgn0031441

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG9962_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031441

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031441

Flygut - An atlas of the Drosophila adult midgut

FBgn0031441

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VQE3

References (33)

The following external sites may use different assemblies or annotations than FlyBase.

4.58

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