Tango3
Please see the JBrowse view of Dmel\Ir48c for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir48c using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ir48c in JBrowse2-65
2-65.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.
dsRNA directed against Tango3 inhibits protein secretion in S2 cells and results in fusion of Golgi membranes with the endoplasmic reticulum in more than 50% of the treated cells.
The Ir48c gene, one of 44 "divergent" ionotropic receptor genes in D. melanogaster, may have been derived from an ancestral ionotropic receptor gene by retroposition, and in some cases, subsequent gene duplication.
Source for identity of: Tango3 CG12444
Source for identity of: Ir48c Tango3
'Tango3' has been renamed to 'Ir48c' for the following reasons: i) This gene was originally named 'Tango3' based on a genome-wide RNAi screen (FBrf0191232, 2006), but a subsequent screen (FBrf0209739, 2010), which claimed to be more robust, failed to validate a role in secretion. Thus calling this gene 'Tango3' is likely inaccurate/misleading. ii) Two other papers refer to this gene as 'IR48c' (FBrf0206496, 2009; FBrf0211681, 2010), as it's a member of the Ionotropic Receptor family.