FlyBase Gene Report: Dmel\PGRP-LB

General Information

Symbol

Dmel\PGRP-LB

Species

D. melanogaster

Name

Peptidoglycan recognition protein LB

Annotation Symbol

CG14704

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037906

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

N-acetylmuramoyl-L-alanine amidase (3.5.1.28)

Gene Summary

Peptidoglycan recognition protein LB (PGRP-LB) encodes a secreted protein with an amidase activity that scavenges DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It negatively regulates the immune deficiency pathway. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

86E6-86E6

Sequence location

3R:11,452,849..11,460,552 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:11452849..11460552

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables N-acetylmuramoyl-L-alanine amidase activity

inferred from direct assay

(Orlans et al., 2021, Zaidman-Remy et al., 2006)

enables protein binding

inferred from physical interaction with UniProtKB:Q9VHB3

(Kim et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables N-acetylmuramoyl-L-alanine amidase activity

inferred from sequence or structural similarity with FLYBASE:PGRP-SC1b; FB:FBgn0033327

(Mellroth et al., 2003)

inferred from electronic annotation with InterPro:IPR002502, InterPro:IPR006619, InterPro:IPR036505

(InterPro Project Members, 2004-)

enables peptidoglycan binding

inferred from electronic annotation with InterPro:IPR017331

(InterPro Project Members, 2004-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR006619

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in defense response to Gram-positive bacterium

inferred from direct assay

(De Gregorio et al., 2002)

involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

inferred from mutant phenotype

(Costechareyre et al., 2016)

involved_in negative regulation of peptidoglycan recognition protein signaling pathway

inferred from direct assay

(Zaidman-Remy et al., 2006)

inferred from mutant phenotype

(Costechareyre et al., 2016, Iatsenko et al., 2016)

involved_in peptidoglycan catabolic process

inferred from direct assay

(Zaidman-Remy et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in innate immune response

non-traceable author statement

(Werner et al., 2000)

inferred from electronic annotation with InterPro:IPR017331

(InterPro Project Members, 2004-)

involved_in peptidoglycan catabolic process

non-traceable author statement

(Werner et al., 2000)

inferred from electronic annotation with InterPro:IPR002502, InterPro:IPR006619, InterPro:IPR036505

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with FLYBASE:PGRP-SC1b; FB:FBgn0033327

(Mellroth et al., 2003)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(De Gregorio et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

LONG PEPTIDOGLYCAN RECOGNITION PROTEINS

N-ACETYLMURAMOYL-L-ALANINE AMIDASES

Pathway (FlyBase)

Negative Regulators of Imd Signaling Pathway

Protein Family (UniProt)

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (Q8INK6)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

N-acetylmuramoyl-L-alanine amidase activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (3.5.1.28)

Summaries

Gene Snapshot

Gene Group (FlyBase)

LONG PEPTIDOGLYCAN RECOGNITION PROTEINS -: Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules of the innate immune response that bind peptidoglycans. Insect PGRPs can be divided into two groups based on transcript size: short PGRPs (PGRP-S) and long PGRPs (PGRP-L). PGRP-L can be intracellular, extracellular, and transmembrane proteins. (Adapted from FBrf0223078).
N-ACETYLMURAMOYL-L-ALANINE AMIDASES -: N-acetylmuramoyl-L-alanine amidases catalyze the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.

Pathway (FlyBase)

Negative Regulators of Imd Signaling Pathway -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)

Protein Function (UniProtKB)

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.

(UniProt, Q8INK6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\PGRP-LB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8INK6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

PGRP-LB-RA

FBtr0082398

NM_141822

1129

215

PGRP-LB-RB

FBtr0082397

NM_169393

1068

215

PGRP-LB-RC

FBtr0082396

NM_169392

1255

232

PGRP-LB-RD

FBtr0306097

NM_001260123

926

255

PGRP-LB-RE

FBtr0306098

NM_001260124

925

215

PGRP-LB-RF

FBtr0306099

NM_001260125

1234

215

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

PGRP-LB-PA

FBpp0081874

23.6

215

8.13

FBpp0081873

23.6

215

8.13

FBpp0081872

25.4

232

8.13

FBpp0297234

27.8

255

7.15

FBpp0297235

23.6

215

8.13

FBpp0297236

23.6

215

8.13

A4V2P5

NP_001247054

AFH06372

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

215 aa isoforms: PGRP-LB-PA, PGRP-LB-PB, PGRP-LB-PE, PGRP-LB-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Monomer.

(UniProt, Q8INK6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PGRP-LB using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval gut

(Costechareyre et al., 2016)

embryonic/larval proventriculus

(Costechareyre et al., 2016)

Additional Descriptive Data

PGRP-LB is expressed in the gut and proventriculus and levels are tied to the immune response.

(Costechareyre et al., 2016)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(De Gregorio et al., 2002)

Expression Deduced from Reporters

Reporter: P{PGRP-LB-GAL4.p1}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult pericardial cell

(Charroux et al., 2018)

adult enterocyte

(Charroux et al., 2018)

intestinal stem cell

(Charroux et al., 2018)

Reporter: P{PGRP-LB-GAL4.p2}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

(Charroux et al., 2018)

adult visceral muscle cell

(Charroux et al., 2018)

adult enterocyte

(Charroux et al., 2018)

intestinal stem cell

(Charroux et al., 2018)

Reporter: P{PGRP-LB-GAL4.p3}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult pericardial cell

(Charroux et al., 2018)

adult oenocyte

(Charroux et al., 2018)

adult visceral muscle cell

(Charroux et al., 2018)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PGRP-LB in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PGRP-LB

View exonic expression by tissue for Dmel\PGRP-LB

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41379/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037906

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037906

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14704

Flygut - An atlas of the Drosophila adult midgut

FBgn0037906

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PGRP-LB

Transgenic constructs containing regulatory region of PGRP-LB

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6160

(Ryder, 2004.4.26)

Df(3R)Exel8153

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4^da.G32

PGRP-LB^500.RNAi.UAS

viable

PGRP-LB^Δ

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

PGRP-LB^GD5166

viable, with Scer\GAL4^pnr-MD237

PGRP-LB^GD5166

viable, with Scer\GAL4^tin.CΔ4

PGRP-LB^GD5166

Sterility

Allele

fertile

PGRP-LB^Δ

Other Phenotypes

Allele

abnormal immune response

PGRP-LB^Δ

abnormal immune response, with Scer\GAL4^da.G32

PGRP-LB^500.RNAi.UAS

abnormal immune response (with Df(3R)Exel8153)

PGRP-LB^Δ

abnormal immune response | adult stage

abnormal immune response | conditional

increased cell death | oogenesis | oogenesis | conditional

PGRP-LB^Δ

short lived

PGRP-LB^Δ

short lived | conditional

PGRP-LB^Δ

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

PGRP-LB^GD5166

some die during pupal stage | heat sensitive, with Scer\GAL4^da.G32

PGRP-LB^500.RNAi.UAS

Phenotype manifest in

Allele

adult fat body | conditional

adult midgut | conditional

adult proventriculus | conditional

PGRP-LB^Δ

egg chamber | adult stage | conditional

PGRP-LB^Δ

lipid droplet | adult stage | conditional

PGRP-LB^Δ

ovary | adult stage | conditional

PGRP-LB^Δ

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\PGLYRP2

7 of 14

Yes

Hsap\PGLYRP1

5 of 14

Hsap\PGLYRP3

3 of 14

Hsap\PGLYRP4

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Pglyrp2

7 of 14

Yes

5 of 14

3 of 14

2 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (4)

Mmus\Pglyrp2

8 of 14

Yes

Mmus\Pglyrp1

5 of 14

Mmus\Pglyrp3

2 of 14

Mmus\Pglyrp4

2 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\pglyrp2

6 of 13

Yes

Xtro\mterf2

4 of 13

Yes

Xtro\pglyrp1-like.1

3 of 13

Xtro\pglyrp1

1 of 13

Danio rerio (Zebrafish) (3)

Drer\pglyrp2

7 of 14

Yes

Drer\pglyrp5

6 of 14

Drer\pglyrp6

6 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\mig-39

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (8)

Agam\PGRPLB

10 of 12

Yes

5 of 12

5 of 12

4 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:PGRP-LB. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PGLYRP2; peptidoglycan recognition protein 2

7 of 14

608199

PGLYRP1; peptidoglycan recognition protein 1

5 of 14

604963

PGLYRP3; peptidoglycan recognition protein 3

3 of 14

608197

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

PGRP-LB - Hrb98DE

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

PGRP-LB

suppressible

PGRP-LC

(Charroux et al., 2018)

PGRP-LB

suppressible

PGRP-LE

(Charroux et al., 2018, Bosco-Drayon et al., 2012)

PGRP-LB

suppressible

PGRP-SD

(Iatsenko et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lam

suppressible

PGRP-LB|PGRP-SC2

(Chen et al., 2014)

External Data

Subunit Structure (UniProtKB)

Monomer.

(UniProt, Q8INK6 )

Linkouts

BioGRID - A database of protein and genetic interactions.

66511

DroID - A comprehensive database of gene and protein interactions.

FBgn0037906

MIST (protein-protein) - An integrated Molecular Interaction Database

41379

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Imd Signaling Pathway -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Toll and Imd signaling pathway

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

86E6-86E6

Sequence location

3R:11,452,849..11,460,552 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86E6-86E6

Limits computationally determined from genome sequence between P{PZ}tho¹&P{PZ}l(3)04629⁰⁵²⁷⁵ and P{EP}Lk6^EP886

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-48.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

55715

w^*; TI{TI}PGRP-LB^Δ

38051

y¹ w^*; Mi{MIC}CG17230^MI04744

67236

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06337}attP40

37079

y¹ w^*; Mi{MIC}PGRP-LB^MI03733 CG17230^MI03733/TM3, Sb¹ Ser¹

NIG-Fly

HMJ21337

y¹ v¹; P{TRiP.HMJ21337}attP40/CyO

VDRC

v104557

P{KK110099}VIE-260B

v13159

w¹¹¹⁸ P{GD5166}v13159

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH21008

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037906

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GH11251

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037906

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

PGRP-LB down-regulates the imd pathway during local immune response.

(Zaidman-Remy et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of PGRP-LB CG14704 was sequence comparison ( date:001020 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: PGRP-LB CG14704

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG14704

(National Institute of Genetics Fly Stocks, 2023-, Douglas et al., 2011, Gendrin et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Hernandez-Romano et al., 2008, Pal et al., 2007, Valanne et al., 2007, De Gregorio et al., 2001, Irving et al., 2001, Lemaitre, 2000.12.20)

PGRP

(Eleftherianos and Heryanto, 2021)

PGRP-LB

(Balakireva et al., 2024, Huang et al., 2024, Bossen et al., 2023, Khan et al., 2023, Krejčová et al., 2023, Meng et al., 2023, Williams et al., 2023, Cammarata-Mouchtouris et al., 2022, Charroux and Royet, 2022, Deshpande et al., 2022, Hodge et al., 2022, Liegeois and Ferrandon, 2022, Liu et al., 2022, Pratomo et al., 2022, Wu et al., 2022, Zhou et al., 2022, Asbah et al., 2021, Ferguson et al., 2021, Orlans et al., 2021, Arora and Ligoxygakis, 2020, Benoit et al., 2020, Bozler et al., 2020, Cho et al., 2020, Dierking and Pita, 2020, Jasper, 2020, Lesperance and Broderick, 2020, Lu et al., 2020, Nishihara, 2020, Ramond et al., 2020, Swanson et al., 2020, Zhou et al., 2020, Zugasti et al., 2020, Hanson et al., 2019, Houtz et al., 2019, Masuzzo et al., 2019, Sanuki et al., 2019, Aranha and Vasconcelos, 2018, Charroux et al., 2018, Fan et al., 2018, Garschall and Flatt, 2018, Min and Tatar, 2018, Troha et al., 2018, Wang et al., 2018, Zhai et al., 2018, Capo et al., 2017, Kounatidis et al., 2017, Kurz et al., 2017, Liu and Jin, 2017, Tavignot et al., 2017, Yadav et al., 2017, Bonfini et al., 2016, Broderick, 2016, Capo et al., 2016, Costechareyre et al., 2016, Guillou et al., 2016, Mistry et al., 2016, Castillo et al., 2015, El Chamy et al., 2015, Kavi et al., 2015, Shiao et al., 2015, Bonnay et al., 2014, Chen et al., 2014, Kleino and Silverman, 2014, Myllymäki et al., 2014, Taylor et al., 2014, Buchon et al., 2013, Erkosar et al., 2013, Ferrandon, 2013, Gendrin et al., 2013, Kuraishi et al., 2013, Marianes and Spradling, 2013, Short and Lazzaro, 2013, Stefanatos et al., 2013, Bosco-Drayon et al., 2012, Eleftherianos and Castillo, 2012, Kounatidis and Ligoxygakis, 2012, Neyen et al., 2012, Apidianakis and Rahme, 2011, Douglas et al., 2011, Paredes et al., 2011, Valanne et al., 2011, Zaidman-Rémy et al., 2011, Ryu et al., 2010, Buchon et al., 2009, Gendrin et al., 2009, Ha et al., 2009, Lee and Edery, 2008, Lhocine et al., 2008, Ryu et al., 2008, Wagner et al., 2008, Curtis et al., 2007, Pal et al., 2007, Sackton et al., 2007, Waterhouse et al., 2007, Zaidman-Remy et al., 2007, Zaidman-Remy et al., 2006, Kim et al., 2005, Wertheim et al., 2005, Reiser et al., 2004, Mellroth et al., 2003, Christophides et al., 2002)

pgrp-LB

(Panda et al., 2015)

pgrp-lb

(Kounatidis et al., 2017)

Name Synonyms

Peptidoglycan recognition protein LB

Peptidoglycan-recognition protein-LB precursor

(Hernandez-Romano et al., 2008)

Secondary FlyBase IDs

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External Crossreferences and Linkouts ( 66 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41379

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8INK6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8INK6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8INK6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037906

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41379/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037906

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037906

FlyMine - An integrated database for Drosophila genomics

FBgn0037906

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG14704

MARRVEL_MODEL - MARRVEL (model organism gene)

41379

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

66511

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037906

DroID - A comprehensive database of gene and protein interactions.

FBgn0037906

DRSC - Results frm RNAi screens

FBgn0037906

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037906

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037906

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14704

Flygut - An atlas of the Drosophila adult midgut

FBgn0037906

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Toll and Imd signaling pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

41379

References (161)

The following external sites may use different assemblies or annotations than FlyBase.

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